Advances in the application of nanotechnology in the diagnosis and treatment of gastrointestinal tumors (Review)
- Authors:
- Bo Sun
- Yantian Fang
- Zhengyang Li
- Zongyou Chen
- Jianbin Xiang
-
Affiliations: Department of General Surgery, Huashan Hospital, Fudan University, Shanghai 200040, P.R. China - Published online on: December 2, 2014 https://doi.org/10.3892/mco.2014.470
- Pages: 274-280
This article is mentioned in:
Abstract
|
Cuenca AG, Jiang H, Hochwald SN, Delano M, Cance WG and Grobmyer SR: Emerging implications of nanotechnology on cancer diagnostics and therapeutics. Cancer. 107:459–466. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Gdowski A, Ranjan AP, Mukerjee A and Vishwanatha JK: Nanobiosensors: role in cancer detection and diagnosis. Adv Exp Med Biol. 807:33–58. 2014.PubMed/NCBI | |
|
Laroui H, Rakhya P, Xiao B, Viennois E and Merlin D: Nanotechnology in diagnostics and therapeutics for gastrointestinal disorders. Dig Liver Dis. 45:995–1002. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Service RF: Nanotoxicology.Nanotechnology grows up. Science. 304:1732–1734. 2004. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang GJ and Ning Y: Silicon nanowire biosensor and its applications in disease diagnostics: a review. Anal Chim Acta. 749:1–15. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Jabir NR, Tabrez S, Ashraf GM, Shakil S, Damanhouri GA and Kamal MA: Nanotechnology-based approaches in anticancer research. Int J Nanomedicine. 7:4391–4408. 2012.PubMed/NCBI | |
|
Shen MY, Li BR and Li YK: Silicon nanowire field-effect-transistor based biosensors: from sensitive to ultra-sensitive. Biosens Bioelectron. 60:101–111. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Wang WU, Chen C, Lin KH, Fang Y and Lieber CM: Label-free detection of small-molecule-protein interactions by using nanowire nanosensors. Proc Natl Acad Sci USA. 102:3208–3212. 2005. View Article : Google Scholar : PubMed/NCBI | |
|
Elnathan R, Kwiat M, Pevzner A, et al: Biorecognition layer engineering: overcoming screening limitations of nanowire-based FET devices. Nano Lett. 12:5245–5254. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang GJ, Chua JH, Chee RE, Agarwal A and Wong SM: Label-free direct detection of m iRNAs with silicon nanowire biosensors. Biosens Bioelectron. 24:2504–2508. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Lee MH, Lee DH, Jung SW, Lee KN, Park YS and Seong WK: Measurements of serum C-reactive protein levels in patients with gastric cancer and quantification using silicon nanowire arrays. Nanomedicine. 6:78–83. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Zheng G, Patolsky F, Cui Y, Wang WU and Lieber CM: Multiplexed electrical detection of cancer markers with nanowire sensor arrays. Nat Biotechnol. 23:1294–1301. 2005. View Article : Google Scholar : PubMed/NCBI | |
|
Stern E, Vacic A, Rajan NK, et al: Label-free biomarker detection from whole blood. Nat Nanotechnol. 5:138–142. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Gupta AK, Nair PR, Akin D, et al: Anomalous resonance in a nanomechanical biosensor. Proc Natl Acad Sci USA. 103:13362–13367. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Meckes B, Arce FT, Connelly LS and Lal R: Insulated conducting cantilevered nanotips and two-chamber recording system for high resolution ion sensing AFM. Sci Rep. 4:44542014. View Article : Google Scholar : PubMed/NCBI | |
|
Lee JH, Hwang KS, Park J, Yoon KH, Yoon DS and Kim TS: Immunoassay of prostate-specific antigen (PSA) using resonant frequency shift of piezoelectric nanomechanical microcantilever. Biosens Bioelectron. 20:2157–2162. 2005. View Article : Google Scholar : PubMed/NCBI | |
|
Savran CA, Knudsen SM, Ellington AD and Manalis SR: Micromechanical detection of proteins using aptamer-based receptor molecules. Anal Chem. 76:3194–3198. 2004. View Article : Google Scholar : PubMed/NCBI | |
|
Hansen KM, Ji HF, Wu G, et al: Cantilever-based optical deflection assay for discrimination of DNA single-nucleotide mismatches. Anal Chem. 73:1567–1571. 2001. View Article : Google Scholar : PubMed/NCBI | |
|
Liao HS, Huang KY, Hwang IS, Chang TJ, Hsiao WW, Lin HH, Hwu ET and Chang CS: Operation of astigmatic-detection atomic force microscopy in liquid environments. Rev Sci Instrum. 84:1037092013. View Article : Google Scholar : PubMed/NCBI | |
|
Gunning AP, Chambers S, Pin C, Man AL, Morris VJ and Nicoletti C: Mapping specific adhesive interactions on living human intestinal epithelial cells with atomic force microscopy. FASEB J. 22:2331–2339. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Krause M, Te Riet J and Wolf K: Probing the compressibility of tumor cell nuclei by combined atomic force-confocal microscopy. Phys Biol. 10:0650022013. View Article : Google Scholar : PubMed/NCBI | |
|
Wu TH, Chiou YW, Chiu WT, Tang MJ, Chen CH and Yeh ML: The F-actin and adherence-dependent mechanical differentiation of normal epithelial cells after TGF-beta1-induced EMT (tEMT) using a microplate measurement system. Biomed Microdevices. 16:465–478. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Zrazhevskiy P, Sena M and Gao X: Designing multifunctional quantum dots for bioimaging, detection, and drug delivery. Chem Soc Rev. 39:4326–4354. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Larson DR, Zipfel WR, Williams RM, et al: Water-soluble quantum dots for multiphoton fluorescence imaging in vivo. Science. 300:1434–1436. 2003. View Article : Google Scholar : PubMed/NCBI | |
|
Morgan NY, English S, Chen W, et al: Real time in vivo non-invasive optical imaging using near-infrared fluorescent quantum dots. Acad Radiol. 12:313–323. 2005. View Article : Google Scholar : PubMed/NCBI | |
|
Rizvi SB, Ghaderi S, Keshtgar M and Seifalian AM: Semiconductor quantum dots as fluorescent probes for in vitro and in vivo bio-molecular and cellular imaging. Nano Rev. 1:Aug 16–2010. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang T, Stilwell JL, Gerion D, et al: Cellular effect of high doses of silica-coated quantum dot profiled with high throughput gene expression analysis and high content cellomics measurements. Nano Lett. 6:800–808. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Wu C, Wang C, Han T, Zhou X, Guo S and Zhang J: Insight into the cellular internalization and cytotoxicity of graphene quantum dots. Adv Healthc Mater. 2:1613–1619. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang H, Fu X, Hu J and Zhu Z: Microfluidic bead-based multienzyme-nanoparticle amplification for detection of circulating tumor cells in the blood using quantum dots labels. Anal Chim Acta. 779:64–71. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Yu Y, Xu L, Chen J, et al: Hydrothermal synthesis of GSH-TGA co-capped CdTe quantum dots and their application in labeling colorectal cancer cells. Colloids Surf B Biointerfaces. 95:247–253. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Gazouli M, Lyberopoulou A, Pericleous P, et al: Development of a quantum-dot-labelled magnetic immunoassay method for circulating colorectal cancer cell detection. World J Gastroenterol. 18:4419–4426. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Bodo J, Durkin L and Hsi ED: Quantitative in situ detection of phosphoproteins in fixed tissues using quantum dot technology. J Histochem Cytochem. 57:701–708. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Ballou B, Ernst LA, Andreko S, et al: Sentinel lymph node imaging using quantum dots in mouse tumor models. Bioconjug Chem. 18:389–396. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Khullar O, Frangioni JV, Grinstaff M and Colson YL: Image-guided sentinel lymph node mapping and nanotechnology-based nodal treatment in lung cancer using invisible near-infrared fluorescent light. Semin Thorac Cardiovasc Surg. 21:309–315. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
He Y, Xu H, Chen C, et al: In situ spectral imaging of marker proteins in gastric cancer with near-infrared and visible quantum dots probes. Talanta. 85:136–141. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Jain R, Dandekar P and Patravale V: Diagnostic nanocarriers for sentinel lymph node imaging. J Control Release. 138:90–102. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Soltesz EG, Kim S, Kim SW, et al: Sentinel lymph node mapping of the gastrointestinal tract by using invisible light. Ann Surg Oncol. 13:386–396. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Hikage M, Gonda K, Takeda M, et al: Nano-imaging of the lymph network structure with quantum dots. Nanotechnology. 21:1851032010. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang YP, Sun P, Zhang XR and Yang WL: In vitro gastric cancer cell imaging using near-infrared quantum dot-conjugated CC49. Oncol Lett. 4:996–1002. 2012.PubMed/NCBI | |
|
Geraldo DA, Duran-Lara EF, Aguayo D, et al: Supramolecular complexes of quantum dots and a polyamidoamine (PAMAM)-folate derivative for molecular imaging of cancer cells. Anal Bioanal Chem. 400:483–492. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Oostendorp M, Douma K, Hackeng TM, et al: Quantitative molecular magnetic resonance imaging of tumor angiogenesis using cNGR-labeled paramagnetic quantum dots. Cancer Res. 68:7676–7683. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Diagaradjane P, Orenstein-Cardona JM, Colon-Casasnovas NE, et al: Imaging epidermal growth factor receptor expression in vivo: pharmacokinetic and biodistribution characterization of a bioconjugated quantum dot nanoprobe. Clin Cancer Res. 14:731–741. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Zhao X, He Y, Gao J, et al: Caveolin-1 expression level in cancer associated fibroblasts predicts outcome in gastric cancer. PLoS One. 8:e591022013. View Article : Google Scholar : PubMed/NCBI | |
|
He Y, Zhao X, Gao J, et al: Quantum dots-based immunofluorescent imaging of stromal fibroblasts caveolin-1 and light chain 3B expression and identification of their clinical significance in human gastric cancer. Int J Mol Sci. 13:13764–13780. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Xing Y, Chaudry Q, Shen C, et al: Bioconjugated quantum dots for multiplexed and quantitative immunohistochemistry. Nat Protoc. 2:1152–1165. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Bostick RM, Kong KY, Ahearn TU, Chaudry Q, Cohen V and Wang MD: Detecting and quantifying biomarkers of risk for colorectal cancer using quantum dots and novel image analysis algorithms. Conf Proc IEEE Eng Med Biol Soc. 1:3313–3316. 2006.PubMed/NCBI | |
|
Hu WQ, Fang M, Zhao HL, et al: Tumor invasion unit in gastric cancer revealed by QDs-based in situ molecular imaging and multispectral analysis. Biomaterials. 35:4125–4132. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Peng CW, Tian Q, Yang GF, et al: Quantum-dots based simultaneous detection of multiple biomarkers of tumor stromal features to predict clinical outcomes in gastric cancer. Biomaterials. 33:5742–5752. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Peng CW, Liu XL, Chen C, et al: Patterns of cancer invasion revealed by QDs-based quantitative multiplexed imaging of tumor microenvironment. Biomaterials. 32:2907–2917. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Svenson S and Tomalia DA: Dendrimers in biomedical applications - reflections on the field. Adv Drug Deliv Rev. 57:2106–2129. 2005. View Article : Google Scholar : PubMed/NCBI | |
|
Kannan RM, Nance E, Kannan S and Tomalia DA: Emerging concepts in dendrimer-based nanomedicine: from design principles to clinical applications. J Intern Med. Jul 3–2014.(Epub ahead of print). View Article : Google Scholar : PubMed/NCBI | |
|
Talanov VS, Regino CA, Kobayashi H, Bernardo M, Choyke PL and Brechbiel MW: Dendrimer-based nanoprobe for dual modality magnetic resonance and fluorescence imaging. Nano Lett. 6:1459–1463. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Davis SS: Biomedical applications of nanotechnology - implications for drug targeting and gene therapy. Trends Biotechnol. 15:217–224. 1997. View Article : Google Scholar : PubMed/NCBI | |
|
Teow HM, Zhou Z, Najlah M, Yusof SR, Abbott NJ and D'Emanuele A: Delivery of paclitaxel across cellular barriers using a dendrimer-based nanocarrier. Int J Pharm. 441:701–711. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Dufes C, Keith WN, Bilsland A, Proutski I, Uchegbu IF and Schatzlein AG: Synthetic anticancer gene medicine exploits intrinsic antitumor activity of cationic vector to cure established tumors. Cancer Res. 65:8079–8084. 2005. View Article : Google Scholar : PubMed/NCBI | |
|
Li Z, Huang ZH, Cui DX, Yao H, Yu JL, Li Q, Pan BF and Gao F: Polyamidoamine dendrimer-mediated survivin antisense oligonucleotide inhibits the growth of subcutaneously transplanted colorectal cancer in nude mice. J South Med Univ. 28:1935–1938. 2008.(In Chinese). | |
|
van der Poll DG, Kieler-Ferguson HM, Floyd WC, et al: Design, synthesis, and biological evaluation of a robust, biodegradable dendrimer. Bioconjug Chem. 21:764–773. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Goldberg DS, Vijayalakshmi N, Swaan PW and Ghandehari H: G3.5 PAMAM dendrimers enhance transepithelial transport of SN38 while minimizing gastrointestinal toxicity. J Control Release. 150:318–325. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Vijayalakshmi N, Ray A, Malugin A and Ghandehari H: Carboxyl-terminated PAMAM-SN38 conjugates: synthesis, characterization, and in vitro evaluation. Bioconjug Chem. 21:1804–1810. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Pan B, Cui D, Sheng Y, et al: Dendrimer-modified magnetic nanoparticles enhance efficiency of gene delivery system. Cancer Res. 67:8156–8163. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Nourazarian AR, Pashaei-Asl R, Omidi Y and Najar AG: c-Src antisense complexed with PAMAM dendrimers decreases c-Src expression and EGFR-dependent downstream genes in the human HT-29 colon cancer cell line. Asian Pac J Cancer Prev. 13:2235–2240. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Morgan MT, Nakanishi Y, Kroll DJ, et al: Dendrimer-encapsulated camptothecins: increased solubility, cellular uptake, and cellular retention affords enhanced anticancer activity in vitro. Cancer Res. 66:11913–11921. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Thiagarajan G, Ray A, Malugin A and Ghandehari H: PAMAM-camptothecin conjugate inhibits proliferation and induces nuclear fragmentation in colorectal carcinoma cells. Pharm Res. 27:2307–2316. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Lee CC, Gillies ER, Fox ME, Guillaudeu SJ, Fréchet JM, Dy EE and Szoka FC: A single dose of doxorubicin-functionalized bow-tie dendrimer cures mice bearing C-26 colon carcinomas. Proc Natl Acad Sci USA. 103:16649–16654. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Tomalia DA, Reyna LA and Svenson S: Dendrimers as multi-purpose nanodevices for oncology drug delivery and diagnostic imaging. Biochem Soc Trans. 35:61–67. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Khosroshahi AG, Amanlou M, Sabzevari O, et al: A comparative study of two novel nanosized radiolabeled analogues of methionine for SPECT tumor imaging. Curr Med Chem. 20:123–133. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Kobayashi H, Sato N, Kawamoto S, et al: 3D MR angiography of intratumoral vasculature using a novel macromolecular MR contrast agent. Magn Reson Med. 46:579–585. 2001. View Article : Google Scholar : PubMed/NCBI | |
|
Kabanov AV and Vinogradov SV: Nanogels as pharmaceutical carriers: finite networks of infinite capabilities. Angew Chem Int Ed Engl. 48:5418–5429. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Arunraj TR, Sanoj Rejinold N, Ashwin Kumar N and Jayakumar R: Bio-responsive chitin-poly(L-lactic acid) composite nanogels for liver cancer. Colloids Surf B Biointerfaces. 113:394–402. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Kong SH, Noh YW, Suh YS, et al: Evaluation of the novel near-infrared fluorescence tracers pullulan polymer nanogel and indocyanine green/gamma-glutamic acid complex for sentinel lymph node navigation surgery in large animal models. Gastric Cancer. Jan 31–2014.(Epub ahead of print). | |
|
Chacko RT, Ventura J, Zhuang J and Thayumanavan S: Polymer nanogels: a versatile nanoscopic drug delivery platform. Adv Drug Deliv Rev. 64:836–851. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Gou M, Men K, Zhang J, et al: Efficient inhibition of C-26 colon carcinoma by VSVMP gene delivered by biodegradable cationic nanogel derived from polyethyleneimine. ACS Nano. 4:5573–5584. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Ashwanikumar N, Kumar NA, Nair SA and Kumar GV: Methacrylic-based nanogels for the pH-sensitive delivery of 5-fluorouracil in the colon. Int J Nanomedicine. 7:5769–5779. 2012.PubMed/NCBI | |
|
Yim H, Park SJ, Bae YH and Na K: Biodegradable cationic nanoparticles loaded with an anticancer drug for deep penetration of heterogeneous tumours. Biomaterials. 34:7674–7682. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Senanayake TH, Warren G and Vinogradov SV: Novel anticancer polymeric conjugates of activated nucleoside analogues. Bioconjug Chem. 22:1983–1993. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Senanayake TH, Warren G, Wei X and Vinogradov SV: Application of activated nucleoside analogs for the treatment of drug-resistant tumors by oral delivery of nanogel-drug conjugates. J Control Release. 167:200–209. 2013. View Article : Google Scholar : PubMed/NCBI |
