Open Access

Clinical significance of serum claudin-1 and claudin-7 levels in patients with colorectal cancer

  • Authors:
    • Mehmet Karabulut
    • Halil Alis
    • Koray Bas
    • Senem Karabulut
    • Cigdem Usul Afsar
    • Hilal Oguz
    • Meral Gunaldi
    • Cevher Akarsu
    • Osman Kones
    • Nuri Faruk Aykan
  • View Affiliations

  • Published online on: August 31, 2015     https://doi.org/10.3892/mco.2015.626
  • Pages: 1255-1267
  • Copyright: © Karabulut et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The present study aimed to investigate the serum levels and clinical relevance of claudin (CLDN) 1 and CLDN7 in patients with colorectal cancer (CRC). A total of 140 patients with a pathologically confirmed diagnosis of CRC were enrolled in this study. The serum levels of CLDN1 and CLDN7 were determined using the solid‑phase sandwich ELISA method. A total of 40 healthy age‑ and gender‑matched controls were included in the analysis. The median age of the patients was 60 years (range, 24‑84 years). The localization of the tumor in the majority of the patients was the colon (n=81, 58%). of the 55 metastatic patients who received palliative chemotheraphy, 31% were chemotherapy‑responsive. The baseline median serum CLDN1 and CLDN7 levels were significantly lower in non‑metastatic and metastatic patients compared with those in healthy controls (CLND1, P=0.008 and 0.002; and CLND7, P=0.002 and 0.002, respectively). Moreover, known clinical variables, including poor performance status and high carcinoembryonic antigen (CEA) levels were found to be associated with lower serum CLDN1 concentrations for all patients (P=0.03 and P=0.03, respectively). High T stage and high CEA levels were found to be correlated with lower serum CLDN7 concentrations for all patients (P=0.04 and 0.03, respectively). A correlation was identified between CLDN1 and CLDN7 levels in non‑metastatic and metastatic CRC patients (both P‑values <0.001). Our study results did not reveal any statistical significance for serum CLDN1 or CLND7 concentrations regarding progression‑free and overall survival rate. Therefore, reduced serum levels of CLDN1 and CLND7 may be useful markers in the differential diagnosis of CRC.
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November-2015
Volume 3 Issue 6

Print ISSN: 2049-9450
Online ISSN:2049-9469

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Spandidos Publications style
Karabulut M, Alis H, Bas K, Karabulut S, Afsar CU, Oguz H, Gunaldi M, Akarsu C, Kones O, Aykan NF, Aykan NF, et al: Clinical significance of serum claudin-1 and claudin-7 levels in patients with colorectal cancer. Mol Clin Oncol 3: 1255-1267, 2015
APA
Karabulut, M., Alis, H., Bas, K., Karabulut, S., Afsar, C.U., Oguz, H. ... Aykan, N.F. (2015). Clinical significance of serum claudin-1 and claudin-7 levels in patients with colorectal cancer. Molecular and Clinical Oncology, 3, 1255-1267. https://doi.org/10.3892/mco.2015.626
MLA
Karabulut, M., Alis, H., Bas, K., Karabulut, S., Afsar, C. U., Oguz, H., Gunaldi, M., Akarsu, C., Kones, O., Aykan, N. F."Clinical significance of serum claudin-1 and claudin-7 levels in patients with colorectal cancer". Molecular and Clinical Oncology 3.6 (2015): 1255-1267.
Chicago
Karabulut, M., Alis, H., Bas, K., Karabulut, S., Afsar, C. U., Oguz, H., Gunaldi, M., Akarsu, C., Kones, O., Aykan, N. F."Clinical significance of serum claudin-1 and claudin-7 levels in patients with colorectal cancer". Molecular and Clinical Oncology 3, no. 6 (2015): 1255-1267. https://doi.org/10.3892/mco.2015.626