Challenges in the management of neuroendocrine cervical cancer during pregnancy: A case report

Gil‑Ibañez,Blanca; Regueiro,Purificacion; Llurba,Elisa; Fariñas‑Madrid,Lorena; Garcia,Angel; Diaz‑Feijoo,Berta

doi:10.3892/mco.2018.1717

Challenges in the management of neuroendocrine cervical cancer during pregnancy: A case report

Authors:
- Blanca Gil‑Ibañez
- Purificacion Regueiro
- Elisa Llurba
- Lorena Fariñas‑Madrid
- Angel Garcia
- Berta Diaz‑Feijoo
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Affiliations: Unit of Gynecological Oncology, Institute Clinic of Gynecology, Obstetrics and Neonatology (ICGON), Hospital Clinic of Barcelona, 08036 Barcelona, Spain, Department of Obstetrics and Gynecology, General Hospital of Hospitalet, 08906 Barcelona, Spain, Department of Obstetrics and Gynecology, Sant Pau University Hospital, Autonomous University of Barcelona, 08041 Barcelona, Spain, Department of Oncology, Vall d'Hebron Institute of Oncology (VHIO), 08035 Barcelona, Spain, Department of Pathology, Vall d'Hebron University Hospital, 08035 Barcelona, Spain, Unit of Gynecological Oncology, Department of Obstetrics and Gynecology, Hospital Materno‑Infantil Vall d'Hebron, Autonomous University of Barcelona, 08035 Barcelona, Spain
Published online on: September 13, 2018 https://doi.org/10.3892/mco.2018.1717
Pages: 519-522

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Abstract

Large‑cell neuroendocrine carcinoma (LCNEC) is an uncommon histological subtype of cervical cancer that is associated with poor survival and its occurrence during pregnancy is particularly rare. We herein present the case of a female patient who was diagnosed with cervical LCNEC during pregnancy. The patient declined pregnancy termination and was treated with neoadjuvant chemotherapy with cisplatin and etoposide, without associated toxicity and with good fetal development. At 31.4 weeks of gestation, the fetus was delivered by caesarean section, and the patient underwent radical nerve‑sparing hysterectomy with bilateral adnexectomy, along with pelvic and inframesenteric para‑aortic lymphadenectomy. The patient received adjuvant chemoradiotherapy and there was no evidence of recurrence or metastasis at 38 months postoperatively. The baby has also been followed up, without any signs of neurodevelopmental disorders. To the best of our knowledge, the present report describes the first case of LCNEC with pregnancy‑preserving management in the literature to date.

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