Open Access

Notch signaling in the pathogenesis, progression and identification of potential targets for cholangiocarcinoma (Review)

  • Authors:
    • Peeranate Vanaroj
    • Wanna Chaijaroenkul
    • Kesara Na‑Bangchang
  • View Affiliations

  • Published online on: January 19, 2022     https://doi.org/10.3892/mco.2022.2499
  • Article Number: 66
  • Copyright: © Vanaroj et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Cholangiocarcinoma (CCA) is an aggressive type of bile duct cancer that is characterized by a high mortality rate due to its late diagnosis and ineffective treatment. The aim of the present systematic review was to analyze the association between Notch signaling and CCA in terms of its pathogenesis, progression and potential treatment targets. Relevant information was gathered from the PubMed, ScienceDirect and Scopus databases using the search terms ‘cholangiocarcinoma’ AND ‘Notch signaling’. Of the 90 articles identified, 28 fulfilled the eligibility criteria and were included in the analysis. It was concluded that overexpression/upregulation of Notch ligands, such as Jagged1 and Notch receptors (Notch1, Notch2 and Notch3), as well as upregulation of the upstream Notch signaling pathway, promoted CCA development and progression. In addition, downregulation of Notch1 signaling through several possible interventions appears to be a promising strategy for inhibition of CCA development and progression. Therefore, the Notch signaling pathway may be considered as a potential target for CCA control.
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March-2022
Volume 16 Issue 3

Print ISSN: 2049-9450
Online ISSN:2049-9469

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Copy and paste a formatted citation
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Spandidos Publications style
Vanaroj P, Chaijaroenkul W and Na‑Bangchang K: Notch signaling in the pathogenesis, progression and identification of potential targets for cholangiocarcinoma (Review). Mol Clin Oncol 16: 66, 2022.
APA
Vanaroj, P., Chaijaroenkul, W., & Na‑Bangchang, K. (2022). Notch signaling in the pathogenesis, progression and identification of potential targets for cholangiocarcinoma (Review). Molecular and Clinical Oncology, 16, 66. https://doi.org/10.3892/mco.2022.2499
MLA
Vanaroj, P., Chaijaroenkul, W., Na‑Bangchang, K."Notch signaling in the pathogenesis, progression and identification of potential targets for cholangiocarcinoma (Review)". Molecular and Clinical Oncology 16.3 (2022): 66.
Chicago
Vanaroj, P., Chaijaroenkul, W., Na‑Bangchang, K."Notch signaling in the pathogenesis, progression and identification of potential targets for cholangiocarcinoma (Review)". Molecular and Clinical Oncology 16, no. 3 (2022): 66. https://doi.org/10.3892/mco.2022.2499