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Characterization of apoptotic changes induced by yessotoxin in the Bel7402 human hepatoma cell line

  • Authors:
    • Min Pang
    • Zong-Ling Wang
    • Chun-Lei Gao
    • Pei Qu
    • Hai-Dong Li

  • View Affiliations

  • Published online on: March 14, 2011     https://doi.org/10.3892/mmr.2011.452
  • Pages: 547-552
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
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Abstract

The apoptotic effects of yessotoxin (YTX) on Bel7402 human hepatoma cells have been evaluated by the combination of several methods, including optical microscopy, Hoechst 33342 staining and DNA gel electrophoresis. Rhodamine 123 staining has also been used to investigate changes in mitochondrial transmembrane potential. The results indicated that YTX has negative effects on human liver cells and induces apoptosis. Furthermore, changes in calcium concentrations were analyzed using the fluorescence probe Fluo-3 AM. The results showed that intracellular calcium concentrations increased after treatment with YTX.

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May-June 2011
Volume 4 Issue 3

Print ISSN: 1791-2997
Online ISSN:1791-3004

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  • Journal Metrics
  • Impact Factor: 3.4
  • Ranked Medicine Research and Experimental
    (total number of cites)
  • CiteScore: 6.9
  • CiteScore Rank: Q2: #98/328 Biochemistry, Genetics and Molecular Biology
  • Source Normalized Impact per Paper (SNIP): 0.721
  • SCImago Journal Rank (SJR): 0.65
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Spandidos Publications style
Pang M, Wang Z, Gao C, Qu P and Li H: Characterization of apoptotic changes induced by yessotoxin in the Bel7402 human hepatoma cell line. Mol Med Rep 4: 547-552, 2011
APA
Pang, M., Wang, Z., Gao, C., Qu, P., & Li, H. (2011). Characterization of apoptotic changes induced by yessotoxin in the Bel7402 human hepatoma cell line. Molecular Medicine Reports, 4, 547-552. https://doi.org/10.3892/mmr.2011.452
MLA
Pang, M., Wang, Z., Gao, C., Qu, P., Li, H."Characterization of apoptotic changes induced by yessotoxin in the Bel7402 human hepatoma cell line". Molecular Medicine Reports 4.3 (2011): 547-552.
Chicago
Pang, M., Wang, Z., Gao, C., Qu, P., Li, H."Characterization of apoptotic changes induced by yessotoxin in the Bel7402 human hepatoma cell line". Molecular Medicine Reports 4, no. 3 (2011): 547-552. https://doi.org/10.3892/mmr.2011.452