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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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July-August 2011 Volume 4 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

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Article

Comparative proteomic analysis of atrial appendages from rheumatic heart disease patients with sinus rhythm and atrial fibrillation

  • Authors:
    • Wen-Jun Huang
    • Rui Zhou
    • Xiao-Rong Zeng
    • Xiao-Qiu Tan
    • Zhi-Hui Cheng
    • Ming-Hai Tang
    • Lan-Tu Gou
    • Li-Juan Chen
    • Ai-Ping Tong
    • Yong He
    • Jin-Liang Yang

  • View Affiliations / Copyright

    Affiliations: State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, P.R. China, Department of Electrophysiology, Institute of Cardiovasology, Luzhou Medical College, Sichuan 646000, P.R. China, Department of Cardiology, State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, P.R. China
  • Pages: 655-661
    |
    Published online on: March 31, 2011
       https://doi.org/10.3892/mmr.2011.468
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Abstract

Atrial fibrillation (AF) is the most common form of arrhythmia encountered in clinical practice, and contributes to cardiovascular morbidity and mortality. Despite significant advances in the understanding of the mechanisms associated with AF, the number of effective biomarkers and viable therapeutic targets remains relatively limited. In this study, 2-DE and MS/MS analysis was used to identify differentially expressed proteins in human atrial appendage tissues from patients with AF (n=4) compared to controls with sinus rhythm (SR; n=5). All subjects had rheumatic heart disease. Following 2-DE analysis, Coomassie Brilliant Blue staining and MS/MS identification, a total of 19 protein spots were found to be differentially expressed between the AF and SR groups. By cluster and metabolic/signaling pathway analysis, these proteins were divided into three major groups: proteins involved in the cytoskeleton and myofilament, energy metabolism associated proteins, and proteins associated with oxidative stress. The proteins identified in this study may enable a better understanding of the molecular mechanisms of AF, and may provide useful biomarkers and novel targets for drug development.

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Copy and paste a formatted citation
Spandidos Publications style
Huang W, Zhou R, Zeng X, Tan X, Cheng Z, Tang M, Gou L, Chen L, Tong A, He Y, He Y, et al: Comparative proteomic analysis of atrial appendages from rheumatic heart disease patients with sinus rhythm and atrial fibrillation. Mol Med Rep 4: 655-661, 2011.
APA
Huang, W., Zhou, R., Zeng, X., Tan, X., Cheng, Z., Tang, M. ... Yang, J. (2011). Comparative proteomic analysis of atrial appendages from rheumatic heart disease patients with sinus rhythm and atrial fibrillation. Molecular Medicine Reports, 4, 655-661. https://doi.org/10.3892/mmr.2011.468
MLA
Huang, W., Zhou, R., Zeng, X., Tan, X., Cheng, Z., Tang, M., Gou, L., Chen, L., Tong, A., He, Y., Yang, J."Comparative proteomic analysis of atrial appendages from rheumatic heart disease patients with sinus rhythm and atrial fibrillation". Molecular Medicine Reports 4.4 (2011): 655-661.
Chicago
Huang, W., Zhou, R., Zeng, X., Tan, X., Cheng, Z., Tang, M., Gou, L., Chen, L., Tong, A., He, Y., Yang, J."Comparative proteomic analysis of atrial appendages from rheumatic heart disease patients with sinus rhythm and atrial fibrillation". Molecular Medicine Reports 4, no. 4 (2011): 655-661. https://doi.org/10.3892/mmr.2011.468
Copy and paste a formatted citation
x
Spandidos Publications style
Huang W, Zhou R, Zeng X, Tan X, Cheng Z, Tang M, Gou L, Chen L, Tong A, He Y, He Y, et al: Comparative proteomic analysis of atrial appendages from rheumatic heart disease patients with sinus rhythm and atrial fibrillation. Mol Med Rep 4: 655-661, 2011.
APA
Huang, W., Zhou, R., Zeng, X., Tan, X., Cheng, Z., Tang, M. ... Yang, J. (2011). Comparative proteomic analysis of atrial appendages from rheumatic heart disease patients with sinus rhythm and atrial fibrillation. Molecular Medicine Reports, 4, 655-661. https://doi.org/10.3892/mmr.2011.468
MLA
Huang, W., Zhou, R., Zeng, X., Tan, X., Cheng, Z., Tang, M., Gou, L., Chen, L., Tong, A., He, Y., Yang, J."Comparative proteomic analysis of atrial appendages from rheumatic heart disease patients with sinus rhythm and atrial fibrillation". Molecular Medicine Reports 4.4 (2011): 655-661.
Chicago
Huang, W., Zhou, R., Zeng, X., Tan, X., Cheng, Z., Tang, M., Gou, L., Chen, L., Tong, A., He, Y., Yang, J."Comparative proteomic analysis of atrial appendages from rheumatic heart disease patients with sinus rhythm and atrial fibrillation". Molecular Medicine Reports 4, no. 4 (2011): 655-661. https://doi.org/10.3892/mmr.2011.468
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