Angiotensinogen gene M235T polymorphism and risk of coronary artery disease: A meta-analysis

Wang,Yu-Jing; Pan,Yan

doi:10.3892/mmr.2012.1011

Angiotensinogen gene M235T polymorphism and risk of coronary artery disease: A meta-analysis

Authors:
- Yu-Jing Wang
- Yan Pan
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Affiliations: Cardiovascular Department, The First Affiliated Hospital of Yangtze University, Medical College of Yangtze University, Shashi District, Jingzhou, Hubei 434000, P.R. China, Department of Pediatrics, The First Affiliated Hospital of Yangtze University, Medical College of Yangtze University, Shashi District, Jingzhou, Hubei 434000, P.R. China
Published online on: July 27, 2012 https://doi.org/10.3892/mmr.2012.1011
Pages: 884-888

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Abstract

The angiotensinogen (AGT) gene M235T polymorphism has been suggested to be linked with susceptibility to coronary artery disease (CAD). In the present study, a meta-analysis was performed to assess the correlation between the M235T polymorphism and CAD. Nine studies with a total of 2281 subjects were selected for inclusion in the analysis. The references were retrieved via PubMed, China National Knowledge Infrastructure, Wanfang and VIP database (1995.1‑2012.1). The analyses were performed using STATA 10.0 software. Odds ratios (OR) with 95% confidence intervals (CIs) were assessed after the collected data were pooled for analysis. A significant association was detected between M235T gene polymorphism and CAD in the population studied. The estimates (OR) of CAD risk were calculated in a homozygote comparison (OR=1.54; 95% CI, 1.09-2.16), a heterozygote comparison (OR=1.30; 95% CI, 1.07-1.58), a dominant model (OR=0.72; 95% CI, 0.55-0.94) and a recessive model (OR=1.37; 95% CI, 0.98-1.91). The current meta-analysis suggests that the M235T polymorphism is associated to an increased risk of CAD.

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