Association between the +104T/C polymorphism in the 5'UTR of GDF5 and susceptibility to knee osteoarthritis: A meta-analysis
- Authors:
View Affiliations
Affiliations: Department of Orthopaedics, General Hospital of Ningxia Medical University, Yinchuan 750004, P.R. China
- Published online on: November 12, 2012 https://doi.org/10.3892/mmr.2012.1179
-
Pages:
485-488
Metrics: Total
Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
This article is mentioned in:
Abstract
Although the +104T/C polymorphism in the 5' untranslated region (UTR) of growth differentiation factor 5 (GDF5) plays a role in the pathogenesis of knee osteoarthritis, the results have been inconsistent. In this study, we performed a meta-analysis to assess the association of +104T/C polymorphism with knee osteoarthritis. Published literature from PubMed, Google Scholar and China National Knowledge Infrastructure data was retrieved. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using fixed- or random-effects models. A total of 6 case-control studies containing 2,744 patients and 4,518 controls were enrolled in this meta-analysis. Overall, a statistically significant association was found between the +104T/C polymorphism and risk of knee osteoarthritis (TT vs. CC:
OR 1.68, 95% CI=1.41-2.01; TT vs. TC: OR 1.18, 95% CI=1.01‑1.38; dominant model: OR 0.72, 95% CI=0.61-0.86). Taking into account the effect of ethnicity, further stratified analyses were performed. In the subgroup analysis, the same association was identified in Caucasian (TT vs. CC: OR 1.45, 95% CI=1.13-1.85) and Asian (TT vs. CC: OR 1.99, 95% CI=1.53‑2.60; TT vs. TC: OR 1.33, 95% CI=1.16-1.52; dominant model: OR 0.64, 95% CI=0.56-0.72; recessive model: OR 1.77, 95% CI=1.37-2.29) populations. The meta-analysis results demonstrated that the +104T/C polymorphism in the 5'-UTR of GDF5 is associated with risk of knee osteoarthritis.
View References
|
1
|
Quintana JM, Arostegui I, Escobar A, et
al: Prevalence of knee and hip osteoarthritis and the
appropriateness of joint replacement in an older population. Arch
Intern Med. 168:1576–1584. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Lementowski PW and Zelicof SB: Obesity and
osteoarthritis. Am J Orthop (Belle Mead NJ). 37:148–151. 2008.
|
|
3
|
Reid CR, Bush PM, Cummings NH, McMullin DL
and Durrani SK: A review of occupational knee disorders. J Occup
Rehabil. 20:489–501. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Valdes AM, Loughlin J, Timms KM, et al:
Genome-wide association scan identifies a
prostaglandin-endoperoxide synthase 2 variant involved in risk of
knee osteoarthritis. Am J Hum Genet. 82:1231–1240. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Nishitoh H, Ichijo H, Kimura M, et al:
Identification of type I and type II serine/threonine kinase
receptors for growth/differentiation factor-5. J Biol Chem.
271:21345–21352. 1996. View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Mikic B, Battaglia TC, Taylor EA, et al:
The effect of growth/differentiation factor-5 deficiency on femoral
composition and mechanical behavior in mice. Bone. 30:733–737.
2002. View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Ding DL, Liu SJ and Zhu HZ: Association
between the CCR2-Val64Ile polymorphism and susceptibility to HIV-1
infection: a meta-analysis. Mol Med Rep. 4:181–186. 2011.PubMed/NCBI
|
|
8
|
Miyamoto Y, Mabuchi A, Shi D, et al: A
functional polymorphism in the 5′ UTR of GDF5 is associated with
susceptibility to osteoarthritis. Nat Genet. 39:529–533. 2007.
|
|
9
|
Southam L, Rodriguez-Lopez J, Wilkins JM,
et al: An SNP in the 5′-UTR of GDF5 is associated with
osteoarthritis susceptibility in Europeans and with in vivo
differences in allelic expression in articular cartilage. Hum Mol
Genet. 16:2226–2232. 2007.
|
|
10
|
Tsezou A, Satra M, Oikonomou P, Bargiotas
K and Malizos KN: The growth differentiation factor 5 (GDF5) core
promoter polymorphism is not associated with knee osteoarthritis in
the Greek population. J Orthop Res. 26:136–140. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Yao C, Dai J and Qin JH: A single nucleid
polymorphisms (SNP) in the 5′UTR of GDF5 is associated with knee
osteoarthritis. Jiangsu Med J. 12:1198–1199. 2008.(In Chinese).
|
|
12
|
Cao Z, Lee HS, Song JH, et al: Growth
differentiation factor 5 (GDF5) core promoter polymorphism is not
associated with susceptibility to osteoarthritis of the knee in the
Korean population. Korean J Pathol. 44:404–409. 2010. View Article : Google Scholar
|
|
13
|
Tawonsawatruk T, Changthong T,
Pingsuthiwong S, et al: A genetic association study between growth
differentiation factor 5 (GDF 5) polymorphism and knee
osteoarthritis in Thai population. J Orthop Surg Res. 6:472011.
View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Storm EE, Huynh TV, Copeland NG, et al:
Limb alterations in brachypodism mice due to mutations in a new
member of the TGF beta-superfamily. Nature. 368:639–643. 1994.
View Article : Google Scholar : PubMed/NCBI
|
