Proteomic study reveals downregulation of apolipoprotein A1 in plasma of poorly controlled diabetes: A pilot study

  • Authors:
    • Hemangi S. Bhonsle
    • Arvind M. Korwar
    • Ashok D. Chougale
    • Sachin  S. Kote
    • Nitin L. Dhande
    • Kishore M. Shelgikar
    • Mahesh J. Kulkarni
  • View Affiliations

  • Published online on: December 4, 2012     https://doi.org/10.3892/mmr.2012.1223
  • Pages: 495-498
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Abstract

Proteomic approaches aid in gaining a better understanding of the pathophysiology of diabetic complications. In view of this, differential protein expression in diabetic plasma samples was studied by a combination of proteomic and western blot analyses. Diabetic plasma samples were categorized based on glycated haemoglobin levels as controlled diabetes (CD; 7-8%), poorly controlled diabetes (PCD; >8%) and non-diabetic control (ND;<6.4%). Two-dimensional electrophoresis and liquid chromatography‑mass spectrometry revealed differential expression of proteins including upregulation of fibrinogen and haptoglobin and downregulation of vitamin D binding protein, α-1-antitrypsin, transthyretin and apolipoprotein A1 (Apo A1) in diabetic compared with non-diabetic plasma samples. Amongst these proteins, Apo A1 downregulation was prominent in PCD. Downregulation of Apo A1 may serve as an early predictive marker of diabetic complications.
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February 2013
Volume 7 Issue 2

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Bhonsle HS, Korwar AM, Chougale AD, Kote SS, Dhande NL, Shelgikar KM and Kulkarni MJ: Proteomic study reveals downregulation of apolipoprotein A1 in plasma of poorly controlled diabetes: A pilot study. Mol Med Rep 7: 495-498, 2013
APA
Bhonsle, H.S., Korwar, A.M., Chougale, A.D., Kote, S.S., Dhande, N.L., Shelgikar, K.M., & Kulkarni, M.J. (2013). Proteomic study reveals downregulation of apolipoprotein A1 in plasma of poorly controlled diabetes: A pilot study. Molecular Medicine Reports, 7, 495-498. https://doi.org/10.3892/mmr.2012.1223
MLA
Bhonsle, H. S., Korwar, A. M., Chougale, A. D., Kote, S. S., Dhande, N. L., Shelgikar, K. M., Kulkarni, M. J."Proteomic study reveals downregulation of apolipoprotein A1 in plasma of poorly controlled diabetes: A pilot study". Molecular Medicine Reports 7.2 (2013): 495-498.
Chicago
Bhonsle, H. S., Korwar, A. M., Chougale, A. D., Kote, S. S., Dhande, N. L., Shelgikar, K. M., Kulkarni, M. J."Proteomic study reveals downregulation of apolipoprotein A1 in plasma of poorly controlled diabetes: A pilot study". Molecular Medicine Reports 7, no. 2 (2013): 495-498. https://doi.org/10.3892/mmr.2012.1223