The A to G polymorphism at -1082 of the interleukin-10 gene is rare in the Han Chinese population

  • Authors:
    • Jing Guo
    • Yong-Hui He
    • Feng Chen
    • Min-Hui Jiang
    • Shu-Ping Gao
    • Ya‑Ming  Su
    • Gui-Liang Shi
    • Xin-Tao Deng
    • Jian-Hua Zhu
    • Min Pan
  • View Affiliations

  • Published online on: July 18, 2012     https://doi.org/10.3892/mmr.2012.995
  • Pages: 894-896
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Abstract

Interleukin-10 (IL-10) is a multifunctional anti‑inflammatory cytokine involved in various physiological and pathophysiological processes including cardiovascular disease. It has been reported that 50-75% of the variation in IL-10 production is genetically controlled. In the present study, the IL‑10 -1082A/G (rs1800896) polymorphism was detected in 174 coronary artery disease (CAD) patients confirmed by selective coronary angiography and 176 age and gender-matched controls from the Jiangsu area (East China). The majority of the subjects (93.14%) carried the AA wild‑type genotype, whereas only 0.29% carried the GG genotype. Our results suggest that IL-10 -1082A/G is rare and unlikely to be a significant contributory to disease susceptibility in the Han Chinese population.
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October 2012
Volume 6 Issue 4

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Guo J, He Y, Chen F, Jiang M, Gao S, Su YM, Shi G, Deng X, Zhu J, Pan M, Pan M, et al: The A to G polymorphism at -1082 of the interleukin-10 gene is rare in the Han Chinese population. Mol Med Rep 6: 894-896, 2012
APA
Guo, J., He, Y., Chen, F., Jiang, M., Gao, S., Su, Y. ... Pan, M. (2012). The A to G polymorphism at -1082 of the interleukin-10 gene is rare in the Han Chinese population. Molecular Medicine Reports, 6, 894-896. https://doi.org/10.3892/mmr.2012.995
MLA
Guo, J., He, Y., Chen, F., Jiang, M., Gao, S., Su, Y., Shi, G., Deng, X., Zhu, J., Pan, M."The A to G polymorphism at -1082 of the interleukin-10 gene is rare in the Han Chinese population". Molecular Medicine Reports 6.4 (2012): 894-896.
Chicago
Guo, J., He, Y., Chen, F., Jiang, M., Gao, S., Su, Y., Shi, G., Deng, X., Zhu, J., Pan, M."The A to G polymorphism at -1082 of the interleukin-10 gene is rare in the Han Chinese population". Molecular Medicine Reports 6, no. 4 (2012): 894-896. https://doi.org/10.3892/mmr.2012.995