Cyclin D1 G870A polymorphism and risk of colorectal cancer: A case control study

Sameer,Aga  Syed; Parray,Fazl  Q.; Dar,Manzoor  Ahmad; Nissar,Saniya; Banday,Mujeeb  Zafar; Rasool,Sabha; Gulzar,G. M.; Chowdri,Nissar  A.; Siddiqi,Mushtaq  A.

doi:10.3892/mmr.2013.1287

Cyclin D1 G870A polymorphism and risk of colorectal cancer: A case control study

Authors:
- Aga Syed Sameer
- Fazl Q. Parray
- Manzoor Ahmad Dar
- Saniya Nissar
- Mujeeb Zafar Banday
- Sabha Rasool
- G. M. Gulzar
- Nissar A. Chowdri
- Mushtaq A. Siddiqi
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Affiliations: Department of Immunology and Molecular Medicine, Sher‑I‑Kashmir Institute of Medical Sciences, Soura, Srinagar, Kashmir, India, Department of General Surgery, Sher‑I‑Kashmir Institute of Medical Sciences, Soura, Srinagar, Kashmir, India, Department of Biotechnology, University of Kashmir, Hazratbal, Srinagar, Kashmir, India, Department of Biochemistry, University of Kashmir, Hazratbal, Srinagar, Kashmir, India, Department of Gastroenterology, Sher‑I‑Kashmir Institute of Medical Sciences, Soura, Srinagar, Kashmir, India
Published online on: January 24, 2013 https://doi.org/10.3892/mmr.2013.1287
Pages: 811-815

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Abstract

The present study aimed to analyse the role of cyclin D1 A870G polymorphism in modulating the susceptibility to colorectal cancer (CRC) in the Kashmiri population. The genotype distribution of the cyclin D1 gene in 130 CRC cases in comparison with 160 healthy controls was investigated. No direct significant association between cyclin D1 genotypes and CRC was observed; however, the AG and AA genotypes were found to be associated with an increased risk of CRC compared to the GG genotype, with an almost 2-fold increase in OR. This study suggests that the cyclin D1 polymorphism is associated with an increased risk of CRC in the Kashmiri population.

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