Pain‑relieving effect of a compound isolated from white peony root oral liquid on acute radiation‑induced esophagitis

Wang,Zhiyu; Shen,Li; Li,Xing; Shu,Xin; Shan,Baoen; Zhang,Li; Gong,Yanjun; Dong,Zhiming

doi:10.3892/mmr.2013.1427

Pain‑relieving effect of a compound isolated from white peony root oral liquid on acute radiation‑induced esophagitis

Authors:
- Zhiyu Wang
- Li Shen
- Xing Li
- Xin Shu
- Baoen Shan
- Li Zhang
- Yanjun Gong
- Zhiming Dong
View Affiliations

Affiliations: Department of Biotherapy, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050011, P.R. China, Department of Traditional Chinese Medicine, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei 050031, P.R. China, Department of Medical Oncology, The General Hospital of Chinese Armed Police Force, Haidian, Beijing 100039, P.R. China, Centre of HMO Administrator of Shijiazhuang, Shijiazhuang, Hebei 050031, P.R. China
Published online on: April 11, 2013 https://doi.org/10.3892/mmr.2013.1427
Pages: 1950-1954

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )

Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )

Cited By (CrossRef): 0 citations Loading Articles...

Abstract

Acute radiation‑induced esophagitis (ARIE) is a common complication of radiotherapy. The aim of this study was to clarify the molecular mechanism of pain relief by the compound of white peony root oral liquid (cWPROL) in ARIE. An animal model of ARIE was established and either cWPROL or a mixture of lidocaine, dexamethasone and gentamycin (mLDG) was administered. We indirectly observed rat symptoms of pain by recording the weight of food and the volume of water consumed by the rats, along with changes in body weight. Additionally, the expression levels of substance P (SP) in the esophageal tissues were detected by immunohistochemistry. It was demonstrated that cWPROL was able to release the pain of ARIE by decreasing the expression of SP; this may be one of the molecular mechanisms via which cWPROL induces pain relief.

View Figures

View References

1	Byhardt RW, Scott C, Sause WT, et al: Response, toxicity, failure patterns, and survival in five Radiation Therapy Oncology Group (RTOG) trails of sequential and/or concurrent chemotherapy and radiotherapy for locally advanced non-small-cell carcinoma of the lung. Int J Radiat Oncol Biol Phys. 42:469–478. 1998. View Article : Google Scholar
2	Bradley J and Movsas B: Radiation esophagitis: Predictive factors and preventive strategies. Semin Radiat Oncol. 14:280–286. 2004. View Article : Google Scholar : PubMed/NCBI
3	Abdel-Latif MM, Duggan S, Reynolds JV and Kelleher D: Inflammation and esophageal carcinogenesis. Curr Opin Pharmacol. 9:396–404. 2009. View Article : Google Scholar : PubMed/NCBI
4	Liu Y, Yu H, Zhang C, Cheng Y, Hu L, Meng X and Zhao Y: Protective effects of berberine on radiation-induced lung injury via intercellular adhesion molecular-1 and transforming growth factor-beta-1 in patients with lung cancer. Eur J Cancer. 44:2425–2432. 2008. View Article : Google Scholar : PubMed/NCBI
5	Yamamoto K, Kureyama N, Asano K, Ikeda T and Yamatodani A: Involvement of substance P and the neurokinin-1 receptor in radiation-induced hair loss in mice. J Pharmacol Sci. 112:118–120. 2010. View Article : Google Scholar : PubMed/NCBI
6	Wang J and Hauer-Jensen M: Neuroimmune interactions: potential target for mitigating or treating intestinal radiation injury. Br J Radiol. 80:S41–S48. 2007. View Article : Google Scholar : PubMed/NCBI
7	Yasui Y, Saper CB and Cechetto DF: Calcitonin gene-related peptide immunoreactivity in the visceral sensory cortex, thalamus, and related pathways in the rat. J Comp Neurol. 290:487–501. 1989. View Article : Google Scholar : PubMed/NCBI
8	Li S, Baoen S, Li Z, et al: Establishment of animal model of radiation esophagitis. Chin J Cancer Prev Treat. 14:13–16. 2007.
9	Nessler S, Stadelmann C, Bittner A, et al: Suppression of autoimmune encephalomyelitis by a neurokinin-1 receptor antagonist - a putative role for substance P in CNS inflammation. J Neuroimmunol. 179:1–8. 2006. View Article : Google Scholar : PubMed/NCBI
10	Korcum AF, Sanlioglu S, Aksu G, Tuncel N and Erin N: Radiotherapy-induced decreases in substance P levels may potentiate melanoma growth. Mol Med Rep. 2:319–326. 2009.PubMed/NCBI
11	Bie BH and Zhao ZQ: Peripheral inflammation alters desensitization of substance P-evoked current in rat dorsal root ganglion neurons. Eur J Pharmacol. 670:495–499. 2011. View Article : Google Scholar : PubMed/NCBI
12	Holzer P: Implications of tachykinins and calcitonin gene-related peptide in inflammatory bowel disease. Digestion. 59:269–283. 1998. View Article : Google Scholar : PubMed/NCBI
13	Christensen HD and Haley TJ: Distribution of substance P in the central nervous system and small intestine of the rat after x-irradiation. Radiat Res. 33:588–595. 1968. View Article : Google Scholar : PubMed/NCBI
14	Foster AP and Cunningham FM: Substance P induces activation, adherence and migration of equine eosinophils. J Vet Pharmacol Ther. 26:131–138. 2003. View Article : Google Scholar : PubMed/NCBI
15	Kosaka Y, Mitsumori M, Araki N, et al: Avascular necrosis of bilateral femoral head as a result of long-term steroid administration for radiation pneumonitis after tangential irradiation of the breast. Int J Clin Oncol. 11:482–486. 2006. View Article : Google Scholar
16	McGinnis WL, Loprinzi CL, Buskirk SJ, et al: Placebo-controlled trail of sucralfate for inhibiting radiation-induced esophagitis. J Clin Oncol. 15:1239–1243. 1997.PubMed/NCBI
17	Movsas B, Scott C, Langer C, et al: Phase III study of amifostine in patients with locally advanced non-small cell lung cancer (NSCLC) receiving chemotherapy and hyperfractionated radiation (chemo/HFxRT): Radiation Therapy Oncology Group (RTOG) 98–01. Proc Am Soc Clin Oncol. 22(abstr 2559): 6362003.
18	Hou W and Zhou Y: Function of traditional Chinese medicine in cancer radiotherapy and its prospect. World Sci Tech. 11:742–746. 2009. View Article : Google Scholar
19	Zhang P and Hu PL: TCM VVM Therapy's influence on tumor patients' survival. Chin J Oncol. 25:3022003.
20	Shen L, Shan BE, Zhang L, et al: Study on preventive and therapeutic function of compound white pony root oral liquid in treating radiation-induced esophagitis. Radiat Protect. 27:119–227. 2007.