Effects of ketamine on lipopolysaccharide-induced depressive-like behavior and the expression of inflammatory cytokines 
in the rat prefrontal cortex

Yang,Chun; Shen,Jiang; Hong,Tao; Hu,Ting-Ting; Li,Zhang-Jun; Zhang,Hai-Tao; Zhang,Yong-Jun; Zhou,Zhi-Qiang; Yang,Jian-Jun

doi:10.3892/mmr.2013.1600

Effects of ketamine on lipopolysaccharide-induced depressive-like behavior and the expression of inflammatory cytokines in the rat prefrontal cortex

Authors:
- Chun Yang
- Jiang Shen
- Tao Hong
- Ting-Ting Hu
- Zhang-Jun Li
- Hai-Tao Zhang
- Yong-Jun Zhang
- Zhi-Qiang Zhou
- Jian-Jun Yang
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Affiliations: Department of Anesthesiology, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu 213003, P.R. China, Department of Anesthesiology, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, Jiangsu 210002, P.R. China
Published online on: July 24, 2013 https://doi.org/10.3892/mmr.2013.1600
Pages: 887-890

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Abstract

The present study was designed to investigate the effects of ketamine on lipopolysaccharide (LPS)-induced depressive-like behavior and the expression of inflammatory cytokines in the rat prefrontal cortex. Thirty male Wistar rats were randomly divided into 3 groups (n=10): saline group (S group), LPS only group (L group) and LPS plus ketamine group (LK group). A forced swimming test (FST) was performed. On the first day, rats were placed into water for 15 min. Twenty-four hours later, rats were treated again as in the first test for a 5 min session, and the immobility time was recorded. The prefrontal cortex was harvested for the determination of the interleukin (IL)‑1β, IL-6 and IL-10 levels. Compared with the S group, rats in the L group had significantly increased immobility time in the FST and expression of IL-1β and IL-6, and significantly decreased expression of IL-10 in the prefrontal cortex (P<0.05). However, rats in the LK group had significantly decreased immobility times in the FST and expression of IL-1β and IL-6, and significantly increased expression of IL-10 in the prefrontal cortex compared with the L group (P<0.05). Ketamine can alleviate LPS-induced depressive-like behavior, and its effect is likely associated with changes in the expression of inflammatory cytokines in the rat prefrontal cortex.

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