Foreign body response induced by tissue expander implantation

Sheng,Lingling; Yu,Qingxiong; Xie,Feng; Li,Qingfeng

doi:10.3892/mmr.2013.1881

Foreign body response induced by tissue expander implantation

Authors:
- Lingling Sheng
- Qingxiong Yu
- Feng Xie
- Qingfeng Li
View Affiliations

Affiliations: Department of Plastic and Reconstructive Surgery, Shanghai 9th People's Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai 200011, P.R. China
Published online on: December 27, 2013 https://doi.org/10.3892/mmr.2013.1881
Pages: 872-876

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )

Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )

Cited By (CrossRef): 0 citations Loading Articles...

Abstract

The foreign body response (FBR) is described as the host's response to implanted biomaterials, which involves a complex cascade of immune modulators. The dynamic changes of immune cells, inflammatory cytokines and the formation of a fibrous capsule remain to be elucidated. In the present study, a model of subcutaneous implantation of a tissue expander was used. The results revealed that macrophages, the main immune cells in FBR, infiltrated into the expanded tissue and located at the tissue‑material interface from day 1‑90. Following the decrease of the number of macrophages, collagen deposited and fibroblasts transformed into myofibroblasts at the tissue‑material interface, leading to the formation of a fibrous capsule from day 14. The persistent existing macrophages led to a high expression of proinflammatory cytokines, including tumor necrosis factor‑α and interleukin‑1β, both of which initiated the NK-κB and JNK inflammatory pathways, mediating the FBR to tissue expander implantation.

View Figures

View References

1	Radovan C: Breast reconstruction after mastectomy using the temporary expander. Plast Reconstr Surg. 69:195–208. 1982. View Article : Google Scholar : PubMed/NCBI
2	Sheng L, Yang M, Du Z, Yang Y and Li Q: Transplantation of stromal vascular fraction as an alternative for accelerating tissue expansion. J Plast Reconstr Aesthet Surg. 66:551–557. 2013. View Article : Google Scholar : PubMed/NCBI
3	Higgins DM, Basaraba RJ, Hohnbaum AC, Lee EJ, Grainger DW and Gonzalez-Juarrero M: Localized immunosuppressive environment in the foreign body response to implanted biomaterials. Am J Pathol. 175:161–70. 2009. View Article : Google Scholar : PubMed/NCBI
4	Joseph J, Mohanty M and Mohanan PV: Role of immune cells and inflammatory cytokines in regulation of fibrosis around silicone expander implants. J Mater Sci Mater Med. 21:1665–76. 2010. View Article : Google Scholar : PubMed/NCBI
5	Broughton G 2nd, Janis JE and Attinger CE: The basic science of wound healing. Plast Reconstr Surg. 117:12S–34S. 2006. View Article : Google Scholar : PubMed/NCBI
6	Tang L, Jennings TA and Eaton JW: Mast cells mediate acute inflammatory responses to implanted biomaterials. Proc Natl Acad Sci USA. 95:8841–6. 1998. View Article : Google Scholar : PubMed/NCBI
7	Seo Y and Murakami M: Monitoring of intracellular ammonium in perfused rat salivary gland by nitrogen-14 nuclear magnetic resonance spectroscopy. Proc Biol Sci. 244:191–6. 1991. View Article : Google Scholar : PubMed/NCBI
8	Brodbeck WG, Nakayama Y, Matsuda T, Colton E, Ziats NP and Anderson JM: Biomaterial surface chemistry dictates adherent monocyte/macrophage cytokine expression in vitro. Cytokine. 18:311–319. 2002. View Article : Google Scholar : PubMed/NCBI
9	Brodbeck WG, Voskerician G, Ziats NP, Nakayama Y, Matsuda T and Anderson JM: In vivo leukocyte cytokine mRNA responses to biomaterials are dependent on surface chemistry. J Biomed Mater Res A. 64:320–329. 2003. View Article : Google Scholar : PubMed/NCBI
10	Kyriakides TR, Foster MJ, Keeney GE, Tsai A, Giachelli CM, Clark-Lewis I, Rollins BJ and Bornstein P: The CC chemokine ligand, CCL2/MCP1, participates in macrophage fusion and foreign body giant cell formation. Am J Pathol. 165:2157–2166. 2004. View Article : Google Scholar : PubMed/NCBI
11	Rodriguez A, Voskerician G, Meyerson H, MacEwan SR and Anderson JM: T cell subset distributions following primary and secondary implantation at subcutaneous biomaterial implant sites. J Biomed Mater Res A. 85:556–565. 2008. View Article : Google Scholar
12	Brodbeck WG, Macewan M, Colton E, Meyerson H and Anderson JM: Lymphocytes and the foreign body response: lymphocyte enhancement of macrophage adhesion and fusion. J Biomed Mater Res A. 74:222–229. 2005. View Article : Google Scholar : PubMed/NCBI
13	Chang DT, Colton E and Anderson JM: Paracrine and juxtacrine lymphocyte enhancement of adherent macrophage and foreign body giant cell activation. J Biomed Mater Res A. 89:490–498. 2009. View Article : Google Scholar : PubMed/NCBI
14	Anderson JM, Rodriguez A and Chang DT: Foreign body reaction to biomaterials. Semin Immunol. 20:86–100. 2008. View Article : Google Scholar : PubMed/NCBI
15	Brandt E, Woerly G, Younes AB, Loiseau S and Capron M: IL-4 production by human polymorphonuclear neutrophils. J Leukoc Biol. 68:125–130. 2000.PubMed/NCBI
16	Woerly G, Lacy P, Younes AB, Roger N, Loiseau S, Moqbel R and Capron M: Human eosinophils express and release IL-13 following CD28-dependent activation. J Leukoc Biol. 72:769–779. 2002.PubMed/NCBI
17	Yoshida M, Mata J and Babensee JE: Effect of poly(lactic-co-glycolic acid) contact on maturation of murine bone marrow-derived dendritic cells. J Biomed Mater Res A. 80:7–12. 2007. View Article : Google Scholar : PubMed/NCBI
18	Granchi D, Cavedagna D, Ciapetti G, Stea S, Schiavon P, Giuliani R and Pizzoferrato A: Silicone breast implants: the role of immune system on capsular contracture formation. J Biomed Mater Res. 29:197–202. 1995. View Article : Google Scholar : PubMed/NCBI
19	Manna SK and Aggarwal BB: Vesnarinone suppresses TNF-induced activation of NF-kappa B, c-Jun kinase, and apoptosis. J Immunol. 164:5815–5825. 2000. View Article : Google Scholar : PubMed/NCBI
20	Ogata M: p38 MAP kinase in the immune response. Tanpakushitsu Kakusan Koso. 47:2261–2267. 2002.(In Japanese).
21	Karin M and Ben-Neriah Y: Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity. Annu Rev Immunol. 18:621–663. 2000.PubMed/NCBI
22	Zandi E, Rothwarf DM, Delhase M, Hayakawa M and Karin M: The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation. Cell. 91:243–252. 1997. View Article : Google Scholar : PubMed/NCBI
23	Ho PJ, Chou CK and Yeh SF: Role of JNK and p38 MAPK in Taiwanin A-induced cell death. Life Sci. 91:1358–1365. 2012. View Article : Google Scholar : PubMed/NCBI
24	Huh JE, Kang KS, Chae C, Kim HM, Ahn KS and Kim SH: Roles of p38 and JNK mitogen-activated protein kinase pathways during cantharidin-induced apoptosis in U937 cells. Biochem Pharmacol. 67:1811–1818. 2004. View Article : Google Scholar : PubMed/NCBI
25	Kang HJ, Soh Y, Kim MS, Lee EJ, Surh YJ, Kim HR, Kim SH and Moon A: Roles of JNK-1 and p38 in selective induction of apoptosis by capsaicin in ras-transformed human breast epithelial cells. Int J Cancer. 103:475–482. 2003. View Article : Google Scholar : PubMed/NCBI
26	Tan KT, Wijeratne D, Shih B, Baildam AD and Bayat A: Tumour necrosis factor-α expression is associated with increased severity of periprosthetic breast capsular contracture. Eur Surg Res. 45:327–332. 2010.