microRNA‑802 promotes lung carcinoma proliferation by targeting the tumor suppressor menin

Wang,Lun‑Qing; Chen,Gang; Liu,Xiang‑Yan; Liu,Fan‑Ying; Jiang,Shao‑Yan; Wang,Zhou

doi:10.3892/mmr.2014.2361

microRNA‑802 promotes lung carcinoma proliferation by targeting the tumor suppressor menin

Authors:
- Lun‑Qing Wang
- Gang Chen
- Xiang‑Yan Liu
- Fan‑Ying Liu
- Shao‑Yan Jiang
- Zhou Wang
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Affiliations: Department of Thoracic Surgery, Provincial Hospital Afﬁliated to Shandong University, Jinan, Shandong 250021, P.R. China, Department of Cardiology, The Affiliated Cardiovascular Hospital of Medical College, Qingdao University, Jinan, Shandong 266071, P.R. China
Published online on: July 1, 2014 https://doi.org/10.3892/mmr.2014.2361
Pages: 1537-1542

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Abstract

microRNAs play important roles in numerous biological processes, including tumorigenesis, by modulating critical gene transcripts. In the present study, the role of microRNA‑802 (miR‑802) in lung cancer was investigated. The results of the quantitative polymerase chain reaction revealed that expression levels of miR‑802 were significantly upregulated in lung cancer tissues. In vitro experiments demonstrated that miR‑802 promoted cell proliferation in A549, NCI‑H358 and NCI‑H1299 cells. Furthermore, it was indicated that miR‑802 promoted the proliferation of lung carcinoma by targeting the tumor suppressor menin. Therefore, these results suggest a previously unknown miR‑802/menin molecular network controlling lung carcinoma development.

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