Efficacy of coenzyme Q10 in mitigating spinal cord injury‑induced osteoporosis

  • Authors:
    • Xue‑Xue Zhang
    • Ke‑Jian Qian
    • Yong Zhang
    • Zhi‑Jian Wang
    • Yan‑Bo Yu
    • Xiao‑Jian Liu
    • Xin‑Tian Cao
    • Yun‑Hua Liao
    • Da‑Ying Zhang
  • View Affiliations

  • Published online on: May 27, 2015     https://doi.org/10.3892/mmr.2015.3856
  • Pages: 3909-3915
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Spinal cord injury (SCI)‑induced osteoporosis may cause mild trauma to bone and increase the risk of bone fracture. The present study aimed to investigate the efficacy of coenzyme Q (CoQ10) on SCI‑induced osteoporosis in rats. SCI was induced by surgical transection of the cord at the T10‑12 level. Animals were treated with CoQ10 (10 mg/kg; intragastrically) daily from 12 h after the surgery and over 10 subsequent days. At the end of the experimental period, blood was collected from the animals and femurs and tibiae were removed for evaluation using biochemical assays. Treatment with CoQ10 prevented SCI‑induced bone loss by rescuing the decreased levels of bone mineral density and bone mineral content observed in the SCI rats. Furthermore, CoQ10 administration reduced bone malondialdehyde levels with a concomitant increase in superoxide dismutase levels, thus alleviating SCI‑induced oxidative injury. In addition, serum inflammatory cytokine levels were markedly increased in rats post‑SCI, which was attenuated by treatment with CoQ10. Finally, the osteoclast‑specific genes receptor activator of nuclear factor kappa‑B ligand and cathepsin K were significantly upregulated and the osteoblast‑specific gene core‑binding factor alpha 1 in the femur was downregulated following SCI, which was effectively restored following treatment with CoQ10. The results suggested that CoQ10 treatment may be effective in attenuating SCI‑induced osteoporosis.
View Figures
View References

Related Articles

Journal Cover

September-2015
Volume 12 Issue 3

Print ISSN: 1791-2997
Online ISSN:1791-3004

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Zhang XX, Qian KJ, Zhang Y, Wang ZJ, Yu YB, Liu XJ, Cao XT, Liao YH and Zhang DY: Efficacy of coenzyme Q10 in mitigating spinal cord injury‑induced osteoporosis. Mol Med Rep 12: 3909-3915, 2015.
APA
Zhang, X., Qian, K., Zhang, Y., Wang, Z., Yu, Y., Liu, X. ... Zhang, D. (2015). Efficacy of coenzyme Q10 in mitigating spinal cord injury‑induced osteoporosis. Molecular Medicine Reports, 12, 3909-3915. https://doi.org/10.3892/mmr.2015.3856
MLA
Zhang, X., Qian, K., Zhang, Y., Wang, Z., Yu, Y., Liu, X., Cao, X., Liao, Y., Zhang, D."Efficacy of coenzyme Q10 in mitigating spinal cord injury‑induced osteoporosis". Molecular Medicine Reports 12.3 (2015): 3909-3915.
Chicago
Zhang, X., Qian, K., Zhang, Y., Wang, Z., Yu, Y., Liu, X., Cao, X., Liao, Y., Zhang, D."Efficacy of coenzyme Q10 in mitigating spinal cord injury‑induced osteoporosis". Molecular Medicine Reports 12, no. 3 (2015): 3909-3915. https://doi.org/10.3892/mmr.2015.3856