Resveratrol induces apoptosis through modulation of the Akt/FoxO3a/Bim pathway in HepG2 cells

Liu,Mi‑Hua; Lin,Xiao‑Long; Li,Jian; He,Jun; Tan,Tian‑Ping; Wu,Shao‑Jian; Yu,Shan; Chen,Li; Liu,Jun; Tian,Wei; Chen,Yu‑Dan; Fu,Hong‑Yun; Yuan,Cong; Zhang,Yuan

doi:10.3892/mmr.2015.4695

Resveratrol induces apoptosis through modulation of the Akt/FoxO3a/Bim pathway in HepG2 cells

Authors:
- Mi‑Hua Liu
- Xiao‑Long Lin
- Jian Li
- Jun He
- Tian‑Ping Tan
- Shao‑Jian Wu
- Shan Yu
- Li Chen
- Jun Liu
- Wei Tian
- Yu‑Dan Chen
- Hong‑Yun Fu
- Cong Yuan
- Yuan Zhang
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Affiliations: Department of Clinical Laboratory, Affiliated Nanhua Hospital, University of South China, Hengyang, Hunan 421001, P.R. China, Department of Pathology, The Third People's Hospital of Huizhou Affiliated to Guangzhou Medical University, Huizhou, Guangdong 516002, P.R. China, Department of Ultrasonic Diagnosis, BoAi Hospital of Zhongshan, Zhongshan, Guangdong 528403, P.R. China, Department of Cardiology, The First Hospital of Changsha, Changsha, Hunan 410005, P.R. China, Department of Pathology, Mawangdui Hospital, Changsha, Hunan 410016, P.R. China
Published online on: December 18, 2015 https://doi.org/10.3892/mmr.2015.4695
Pages: 1689-1694

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Abstract

Resveratrol is a polyphenolic compound found in wine, which is mainly produced by the grapevine and exerts chemopreventive effects against hepatocellular carcinoma. However, the underlying molecular mechanisms have remained to be fully elucidated. The present study assessed whether resveratrol-induced apoptosis was mediated via the activation of the forkhead box O3a (FoxO3a) transcription factor. It was demonstrated that resveratrol treatment induced apoptosis in HepG2 cells, and that this pro‑apoptotic effect was accompanied with increases in the expression of apoptotic protein Bim. Following resveratrol treatment, Akt-mediated phosphorylation of FoxO3a was observed to be diminished in HepG2 cells. Furthermore, resveratrol enhanced the nuclear levels of FoxO3a and mediated neuronal death via Bim. The present study demonstrated that resveratrol induced apoptosis in HepG2 cells through activation of the transcription factor FoxO3a and increasing the expression of Bim protein.

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