Isoquercetin ameliorates myocardial infarction through anti-inflammation and anti-apoptosis factor and regulating TLR4-NF-κB signal pathway

  • Authors:
    • Chengtai Ma
    • Yanxia Jiang
    • Xiaohui Zhang
    • Xiaoxue Chen
    • Zhenfang Liu
    • Xintao Tian
  • View Affiliations

  • Published online on: March 9, 2018     https://doi.org/10.3892/mmr.2018.8709
  • Pages: 6675-6680
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Abstract

The aim of the present study was to investigate the protective mechanisms and identify the effects of isoquercetin on myocardial infarction in a rat model of acute myocardial infarction (AMI). Isoquercetin ameliorated myocardial infarct size, creatine kinase (CK), CK‑MB and lactic dehydrogenase activity and inhibited inflammation, oxidative stress and heart cell apoptosis in a rat with AMI. Isoquercetin increased endothelial nitric oxide synthase, reduced inducible nitric oxide synthase levels and suppressed the Toll-like receptor 4‑nuclear factor (TLR4‑NF)‑κB signaling pathway in a rat with AMI. Overall, isoquercetin ameliorated AMI through anti‑inflammatory and anti‑apoptotic factors, and regulation of the TLR4‑NF‑κB signaling pathway. Isoquercetin may therefore potentially exert a protective effect against AMI or other heart diseases.
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May-2018
Volume 17 Issue 5

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Ma C, Jiang Y, Zhang X, Chen X, Liu Z and Tian X: Isoquercetin ameliorates myocardial infarction through anti-inflammation and anti-apoptosis factor and regulating TLR4-NF-κB signal pathway. Mol Med Rep 17: 6675-6680, 2018.
APA
Ma, C., Jiang, Y., Zhang, X., Chen, X., Liu, Z., & Tian, X. (2018). Isoquercetin ameliorates myocardial infarction through anti-inflammation and anti-apoptosis factor and regulating TLR4-NF-κB signal pathway. Molecular Medicine Reports, 17, 6675-6680. https://doi.org/10.3892/mmr.2018.8709
MLA
Ma, C., Jiang, Y., Zhang, X., Chen, X., Liu, Z., Tian, X."Isoquercetin ameliorates myocardial infarction through anti-inflammation and anti-apoptosis factor and regulating TLR4-NF-κB signal pathway". Molecular Medicine Reports 17.5 (2018): 6675-6680.
Chicago
Ma, C., Jiang, Y., Zhang, X., Chen, X., Liu, Z., Tian, X."Isoquercetin ameliorates myocardial infarction through anti-inflammation and anti-apoptosis factor and regulating TLR4-NF-κB signal pathway". Molecular Medicine Reports 17, no. 5 (2018): 6675-6680. https://doi.org/10.3892/mmr.2018.8709