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Article Open Access

Upregulation of miR-614 promotes proliferation and inhibits apoptosis in ovarian cancer by suppressing PPP2R2A expression

  • Authors:
    • Jing Zhang
    • Dongdong Gao
    • Hui Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Traditional Chinese Medicine Gynecology, Central Hospital of Zhumadian, Huang Huai University, Zhumadian, Henan 463000, P.R. China, Department of Oncology, Central Hospital of Zhumadian, Huang Huai University, Zhumadian, Henan 463000, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 6285-6292
    |
    Published online on: March 9, 2018
       https://doi.org/10.3892/mmr.2018.8714
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Abstract

It has previously been demonstrated that microRNAs (miRNAs) have essential roles and participate in various biological processes by regulating their specific target genes. However, the precise role of miRNAs in ovarian cancer (OC) has not yet been elucidated. The present study demonstrated that miR‑614 expression levels were significantly upregulated in OC tissues and cell lines, whereas decreased miR‑614 demonstrated opposite effects. Furthermore, gain‑of‑function and loss‑of‑function experiments indicated that miR‑614 overexpression promoted cell proliferation and suppressed cell apoptosis. Protein phosphatase 2 regulatory subunit B α, (PPP2R2A) was identified as a direct target of miR‑614 using western blotting and luciferase reporter assays. Notably, silencing of PPP2R2A counter‑acted the effect of miR‑614 inhibitor in OC cell proliferation and cell apoptosis. Overall, the data suggested that miR‑614 promoted cell proliferation and inhibited cell apoptosis of OC cells by targeting PPP2R2A, and may therefore act as a potential target for OC therapy in the future.
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1 

Siegel R, Ma J, Zou Z and Jemal A: Cancer statistics, 2014. CA Cancer J Clin. 64:9–29. 2014. View Article : Google Scholar : PubMed/NCBI

2 

Krishnan V, Berek JS and Dorigo O: Immunotherapy in ovarian cancer. Curr Probl Cancer. 41:48–63. 2016. View Article : Google Scholar : PubMed/NCBI

3 

Xie F, Yuan Y, Xie L, Ran P, Xiang X, Huang Q, Qi G, Guo X, Xiao C and Zheng S: miRNA-320a inhibits tumor proliferation and invasion by targeting c-Myc in human hepatocellular carcinoma. Onco Targets Ther. 10:885–894. 2017. View Article : Google Scholar : PubMed/NCBI

4 

Hu Y, Xie H, Liu Y, Liu W, Liu M and Tang H: miR-484 suppresses proliferation and epithelial-mesenchymal transition by targeting ZEB1 and SMAD2 in cervical cancer cells. Cancer Cell Int. 17:362017. View Article : Google Scholar : PubMed/NCBI

5 

Gao Y, Lin L, Li T, Yang J and Wei Y: The role of miRNA-223 in cancer: Function, diagnosis and therapy. Gene. 616:1–17. 2017. View Article : Google Scholar : PubMed/NCBI

6 

Arechaga-Ocampo E, Lopez-Camarillo C, Villegas-Sepulveda N, Gonzalez-De la Rosa CH, Perez-Añorve IX, Roldan-Perez R, Flores-Perez A, Peña-Curiel O, Angeles-Zaragoza O, Rangel Corona R, et al: Tumor suppressor miR-29c regulates radioresistance in lung cancer cells. Tumour Biol. 39:10104283176950102017. View Article : Google Scholar : PubMed/NCBI

7 

Wang W, Yang J, Xiang YY and Pi J: Overexpression of Hsa-miR-320 Is associated with invasion and metastasis of ovarian cancer. J Cell Biochem. 118:3654–3661. 2017. View Article : Google Scholar : PubMed/NCBI

8 

Xu J, Jiang N, Shi H, Zhao S, Yao S and Shen H: miR-28-5p promotes the development and progression of ovarian cancer through inhibition of N4BP1. Int J Oncol. Mar 16–2017.(Epub ahead of print). View Article : Google Scholar

9 

Bai L, Wang H, Wang AH, Zhang LY and Bai J: MicroRNA-532 and microRNA-3064 inhibit cell proliferation and invasion by acting as direct regulators of human telomerase reverse transcriptase in ovarian cancer. PLoS One. 12:e01739122017. View Article : Google Scholar : PubMed/NCBI

10 

Pan Y, Robertson G, Pedersen L, Lim E, Hernandez-Herrera A, Rowat AC, Patil SL, Chan CK, Wen Y, Zhang X, et al: miR-509-3p is clinically significant and strongly attenuates cellular migration and multi-cellular spheroids in ovarian cancer. Oncotarget. 7:25930–25948. 2016.PubMed/NCBI

11 

Zhang J, Liu L, Sun Y, Xiang J, Zhou D, Wang L, Xu H, Yang X, Du N, Zhang M, et al: MicroRNA-520 g promotes epithelial ovarian cancer progression and chemoresistance via DAPK2 repression. Oncotarget. 7:26516–26534. 2016.PubMed/NCBI

12 

Wu AH, Huang YL, Zhang LZ, Tian G, Liao QZ and Chen SL: MiR-572 prompted cell proliferation of human ovarian cancer cells by suppressing PPP2R2C expression. Biomed Pharmacother. 77:92–97. 2016. View Article : Google Scholar : PubMed/NCBI

13 

Xia B, Li H, Yang S, Liu T and Lou G: MiR-381 inhibits epithelial ovarian cancer malignancy via YY1 suppression. Tumour Biol. 37:9157–9167. 2016. View Article : Google Scholar : PubMed/NCBI

14 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

15 

Cao C, Sun D, Zhang L and Song L: miR-186 affects the proliferation, invasion and migration of human gastric cancer by inhibition of Twist1. Oncotarget. 7:79956–79963. 2016. View Article : Google Scholar : PubMed/NCBI

16 

Lei ST, Shen F, Chen JW, Feng JH, Cai WS, Shen L, Hu ZW and Xu B: MiR-639 promoted cell proliferation and cell cycle in human thyroid cancer by suppressing CDKN1A expression. Biomed Pharmacother. 84:1834–1840. 2016. View Article : Google Scholar : PubMed/NCBI

17 

Fu X, Li Y, Alvero A, Li J, Wu Q, Xiao Q, Peng Y, Hu Y, Li X, Yan W, et al: MicroRNA-222-3p/GNAI2/AKT axis inhibits epithelial ovarian cancer cell growth and associates with good overall survival. Oncotarget. 7:80633–80654. 2016. View Article : Google Scholar : PubMed/NCBI

18 

Wen Z, Zhao S, Liu S, Liu Y, Li X and Li S: MicroRNA-148a inhibits migration and invasion of ovarian cancer cells via targeting sphingosine-1-phosphate receptor 1. Mol Med Rep. 12:3775–3780. 2015. View Article : Google Scholar : PubMed/NCBI

19 

Baez-Vega PM, Echevarria Vargas IM, Valiyeva F, Encarnación-Rosado J, Roman A, Flores J, Marcos-Martínez MJ and Vivas-Mejía PE: Targeting miR-21-3p inhibits proliferation and invasion of ovarian cancer cells. Oncotarget. 7:36321–36337. 2016. View Article : Google Scholar : PubMed/NCBI

20 

Xiaohong Z, Lichun F, Na X, Kejian Z, Xiaolan X and Shaosheng W: MiR-203 promotes the growth and migration of ovarian cancer cells by enhancing glycolytic pathway. Tumour Biol. 37:14989–14997. 2016. View Article : Google Scholar : PubMed/NCBI

21 

Zeng LP, Hu ZM, Li K and Xia K: miR-222 attenuates cisplatin-induced cell death by targeting the PPP2R2A/Akt/mTOR Axis in bladder cancer cells. J Cell Mol Med. 20:559–567. 2016. View Article : Google Scholar : PubMed/NCBI

22 

Zeng LP, Hu ZM, Li K and Xia K: miR-222 attenuates cisplatin-induced cell death by targeting the PPP2R2A/Akt/mTOR Axis in bladder cancer cells. J Cell Mol Med. 20:559–567. 2016. View Article : Google Scholar : PubMed/NCBI

23 

Hein AL, Seshacharyulu P, Rachagani S, Sheinin YM, Ouellette MM, Ponnusamy MP, Mumby MC, Batra SK and Yan Y: PR55α subunit of protein phosphatase 2A supports the tumorigenic and metastatic potential of pancreatic cancer cells by sustaining hyperactive oncogenic signaling. Cancer Res. 76:2243–2253. 2016. View Article : Google Scholar : PubMed/NCBI

24 

Zhang Y, Ma T, Yang S, Xia M, Xu J, An H, Yang Y and Li S: High-mobility group A1 proteins enhance the expression of the oncogenic miR-222 in lung cancer cells. Mol Cell Biochem. 357:363–371. 2011. View Article : Google Scholar : PubMed/NCBI

25 

Shen S, Yue H, Li Y, Qin J, Li K, Liu Y and Wang J: Upregulation of miR-136 in human non-small cell lung cancer cells promotes Erk1/2 activation by targeting PPP2R2A. Tumour Biol. 35:631–640. 2014. View Article : Google Scholar : PubMed/NCBI

26 

Liu X, Sempere LF, Ouyang H, Memoli VA, Andrew AS, Luo Y, Demidenko E, Korc M, Shi W, Preis M, et al: MicroRNA-31 functions as an oncogenic microRNA in mouse and human lung cancer cells by repressing specific tumor suppressors. J Clin Invest. 120:1298–1309. 2010. View Article : Google Scholar : PubMed/NCBI

27 

Liang WL, Cao J, Xu B, Yang P, Shen F, Sun Z, Li WL, Wang Q and Liu F: miR-892a regulated PPP2R2A expression and promoted cell proliferation of human colorectal cancer cells. Biomed Pharmacother. 72:119–124. 2015. View Article : Google Scholar : PubMed/NCBI

28 

Wong QW, Ching AK, Chan AW, Choy KW, To KF, Lai PB and Wong N: MiR-222 overexpression confers cell migratory advantages in hepatocellular carcinoma through enhancing AKT signaling. Clin Cancer Res. 16:867–875. 2010. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zhang J, Gao D and Zhang H: Upregulation of miR-614 promotes proliferation and inhibits apoptosis in ovarian cancer by suppressing PPP2R2A expression. Mol Med Rep 17: 6285-6292, 2018.
APA
Zhang, J., Gao, D., & Zhang, H. (2018). Upregulation of miR-614 promotes proliferation and inhibits apoptosis in ovarian cancer by suppressing PPP2R2A expression. Molecular Medicine Reports, 17, 6285-6292. https://doi.org/10.3892/mmr.2018.8714
MLA
Zhang, J., Gao, D., Zhang, H."Upregulation of miR-614 promotes proliferation and inhibits apoptosis in ovarian cancer by suppressing PPP2R2A expression". Molecular Medicine Reports 17.5 (2018): 6285-6292.
Chicago
Zhang, J., Gao, D., Zhang, H."Upregulation of miR-614 promotes proliferation and inhibits apoptosis in ovarian cancer by suppressing PPP2R2A expression". Molecular Medicine Reports 17, no. 5 (2018): 6285-6292. https://doi.org/10.3892/mmr.2018.8714
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang J, Gao D and Zhang H: Upregulation of miR-614 promotes proliferation and inhibits apoptosis in ovarian cancer by suppressing PPP2R2A expression. Mol Med Rep 17: 6285-6292, 2018.
APA
Zhang, J., Gao, D., & Zhang, H. (2018). Upregulation of miR-614 promotes proliferation and inhibits apoptosis in ovarian cancer by suppressing PPP2R2A expression. Molecular Medicine Reports, 17, 6285-6292. https://doi.org/10.3892/mmr.2018.8714
MLA
Zhang, J., Gao, D., Zhang, H."Upregulation of miR-614 promotes proliferation and inhibits apoptosis in ovarian cancer by suppressing PPP2R2A expression". Molecular Medicine Reports 17.5 (2018): 6285-6292.
Chicago
Zhang, J., Gao, D., Zhang, H."Upregulation of miR-614 promotes proliferation and inhibits apoptosis in ovarian cancer by suppressing PPP2R2A expression". Molecular Medicine Reports 17, no. 5 (2018): 6285-6292. https://doi.org/10.3892/mmr.2018.8714
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