Open Access

Role of hypoxia inducible factor-1 in cancer stem cells (Review)

  • Authors:
    • Qi Zhang
    • Zhenzhen Han
    • Yanbo Zhu
    • Jingcheng Chen
    • Wei Li
  • View Affiliations

  • Published online on: November 3, 2020     https://doi.org/10.3892/mmr.2020.11655
  • Article Number: 17
  • Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Cancer stem cells (CSCs) have been found to play a decisive role in cancer recurrence, metastasis, and chemo‑, radio‑ and immuno‑resistance. Understanding the mechanism of CSC self‑renewal and proliferation may help overcome the limitations of clinical treatment. The microenvironment of tumor growth consists of a lack of oxygen, and hypoxia has been confirmed to induce cancer cell invasion, metastasis and epithelial‑mesenchymal transition, and is usually associated with poor prognosis and low survival rates. Hypoxia inducible factor‑1 (HIF‑1) can be stably expressed under hypoxia and act as an important molecule to regulate the development of CSCs, but the specific mechanism remains unclear. The present review attempted to explain the role of HIF‑1 in the generation and maintenance of CSCs from the perspective of epigenetics, metabolic reprogramming, tumor immunity, CSC markers, non‑coding RNA and signaling pathways associated with HIF‑1, in order to provide novel targets with HIF‑1 as the core for clinical treatment, and extend the life of patients.
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January-2021
Volume 23 Issue 1

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Copy and paste a formatted citation
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Spandidos Publications style
Zhang Q, Han Z, Zhu Y, Chen J and Li W: Role of hypoxia inducible factor-1 in cancer stem cells (Review). Mol Med Rep 23: 17, 2021
APA
Zhang, Q., Han, Z., Zhu, Y., Chen, J., & Li, W. (2021). Role of hypoxia inducible factor-1 in cancer stem cells (Review). Molecular Medicine Reports, 23, 17. https://doi.org/10.3892/mmr.2020.11655
MLA
Zhang, Q., Han, Z., Zhu, Y., Chen, J., Li, W."Role of hypoxia inducible factor-1 in cancer stem cells (Review)". Molecular Medicine Reports 23.1 (2021): 17.
Chicago
Zhang, Q., Han, Z., Zhu, Y., Chen, J., Li, W."Role of hypoxia inducible factor-1 in cancer stem cells (Review)". Molecular Medicine Reports 23, no. 1 (2021): 17. https://doi.org/10.3892/mmr.2020.11655