Role of hypoxia inducible factor-1 in cancer stem cells (Review)
- Authors:
- Qi Zhang
- Zhenzhen Han
- Yanbo Zhu
- Jingcheng Chen
- Wei Li
-
Affiliations: Stem Cell and Cancer Center, The First Hospital of Jilin University, Changchun, Jilin 130061, P.R. China - Published online on: November 3, 2020 https://doi.org/10.3892/mmr.2020.11655
- Article Number: 17
-
Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
This article is mentioned in:
Abstract
Lagunas-Rangel FA: Circular RNAs and their participation in stemness of cancer. Med Oncol. 37:422020. View Article : Google Scholar : PubMed/NCBI | |
Wang H, Cui G, Yu B, Sun M and Yang H: Cancer stem cell niche in colorectal cancer and targeted therapies. Curr Pharm Des. 26:1979–1993. 2020. View Article : Google Scholar : PubMed/NCBI | |
Sureshbabu SK, Chaukar D and Chiplunkar SV: Hypoxia regulates the differentiation and anti-tumor effector functions of γδT cells in oral cancer. Clin Exp Immunol. 201:40–57. 2020. View Article : Google Scholar : PubMed/NCBI | |
Zhang C, Samanta D, Lu H, Bullen JW, Zhang H, Chen I, He X and Semenza GL: Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5-mediated m6A-demethylation of NANOG mRNA. Proc Natl Acad Sci USA. 113:E2047–E2056. 2016. View Article : Google Scholar : PubMed/NCBI | |
Xu QH, Xiao Y, Li XQ, Fan L, Zhou CC, Cheng L, Jiang ZD and Wang GH: Resveratrol Counteracts Hypoxia-Induced Gastric Cancer Invasion and EMT through Hedgehog Pathway Suppression. Anticancer Agents Med Chem. 20:1105–1114. 2020. View Article : Google Scholar : PubMed/NCBI | |
Ajduković J: HIF-1 - a big chapter in the cancer tale. Exp Oncol. 38:9–12. 2016. View Article : Google Scholar : PubMed/NCBI | |
Schito L and Semenza GL: Hypoxia-inducible factors: Master regulators of cancer progression. Trends Cancer. 2:758–770. 2016. View Article : Google Scholar : PubMed/NCBI | |
Lu Y, Wang L, Ding W, Wang D, Wang X, Luo Q and Zhu L: Ammonia mediates mitochondrial uncoupling and promotes glycolysis via HIF-1 activation in human breast cancer MDA-MB-231 cells. Biochem Biophys Res Commun. 519:153–159. 2019. View Article : Google Scholar : PubMed/NCBI | |
Azimi I: The interplay between HIF-1 and calcium signalling in cancer. Int J Biochem Cell Biol. 97:73–77. 2018. View Article : Google Scholar : PubMed/NCBI | |
Hong M, Shi H, Wang N, Tan HY, Wang Q and Feng Y: Dual effects of Chinese herbal medicines on angiogenesis in cancer and ischemic stroke treatments: Role of HIF-1 network. Front Pharmacol. 10:6962019. View Article : Google Scholar : PubMed/NCBI | |
Albadari N, Deng S and Li W: The transcriptional factors HIF-1 and HIF-2 and their novel inhibitors in cancer therapy. Expert Opin Drug Discov. 14:667–682. 2019. View Article : Google Scholar : PubMed/NCBI | |
Garner KEL, Hull NJ, Sims AH, Lamb R and Clarke RB: The milk protein alpha-casein suppresses triple negative breast cancer stem cell activity via STAT and HIF-1alpha signalling pathways in breast cancer cells and fibroblasts. J Mammary Gland Biol Neoplasia. 24:245–256. 2019. View Article : Google Scholar : PubMed/NCBI | |
Masoud GN and Li W: HIF-1α pathway: Role, regulation and intervention for cancer therapy. Acta Pharm Sin B. 5:378–389. 2015. View Article : Google Scholar : PubMed/NCBI | |
Chan ST, Patel PR, Ransom TR, Henrich CJ, McKee TC, Goey AK, Cook KM, Figg WD, McMahon JB, Schnermann MJ, et al: Structural elucidation and synthesis of eudistidine A: An unusual polycyclic marine alkaloid that blocks interaction of the protein binding domains of p300 and HIF-1α. J Am Chem Soc. 137:5569–5575. 2015. View Article : Google Scholar : PubMed/NCBI | |
Freedman SJ, Sun ZY, Kung AL, France DS, Wagner G and Eck MJ: Structural basis for negative regulation of hypoxia-inducible factor-1alpha by CITED2. Nat Struct Biol. 10:504–512. 2003. View Article : Google Scholar : PubMed/NCBI | |
Kasper LH, Boussouar F, Boyd K, Xu W, Biesen M, Rehg J, Baudino TA, Cleveland JL and Brindle PK: Two transactivation mechanisms cooperate for the bulk of HIF-1-responsive gene expression. EMBO J. 24:3846–3858. 2005. View Article : Google Scholar : PubMed/NCBI | |
Henchey LK, Kushal S, Dubey R, Chapman RN, Olenyuk BZ and Arora PS: Inhibition of hypoxia inducible factor 1-transcription coactivator interaction by a hydrogen bond surrogate alpha-helix. J Am Chem Soc. 132:941–943. 2010. View Article : Google Scholar : PubMed/NCBI | |
Cai X, Huang Y, Zhang X, Wang S, Zou Z, Wang G, Wang Y and Zhang Z: Cloning, characterization, hypoxia and heat shock response of hypoxia inducible factor-1 (HIF-1) from the small abalone Haliotis diversicolor. Gene. 534:256–264. 2014. View Article : Google Scholar : PubMed/NCBI | |
Hu CJ, Sataur A, Wang L, Chen H and Simon MC: The N-terminal transactivation domain confers target gene specificity of hypoxia-inducible factors HIF-1alpha and HIF-2alpha. Mol Biol Cell. 18:4528–4542. 2007. View Article : Google Scholar : PubMed/NCBI | |
Soñanez-Organis JG, Peregrino-Uriarte AB, Gómez-Jiménez S, López-Zavala A, Forman HJ and Yepiz-Plascencia G: Molecular characterization of hypoxia inducible factor-1 (HIF-1) from the white shrimp Litopenaeus vannamei and tissue-specific expression under hypoxia. Comp Biochem Physiol C Toxicol Pharmacol. 150:395–405. 2009. View Article : Google Scholar : PubMed/NCBI | |
Soni S and Padwad YS: HIF-1 in cancer therapy: Two decade long story of a transcription factor. Acta Oncol. 56:503–515. 2017. View Article : Google Scholar : PubMed/NCBI | |
Ju UI, Park JW, Park HS, Kim SJ and Chun YS: FBXO11 represses cellular response to hypoxia by destabilizing hypoxia-inducible factor-1α mRNA. Biochem Biophys Res Commun. 464:1008–1015. 2015. View Article : Google Scholar : PubMed/NCBI | |
Mandl M and Depping R: Hypoxia-inducible aryl hydrocarbon receptor nuclear translocator (ARNT) (HIF-1β): Is it a rare exception? Mol Med. 20:215–220. 2014. View Article : Google Scholar : PubMed/NCBI | |
Qiu Y, Shan W, Yang Y, Jin M, Dai Y, Yang H, Jiao R, Xia Y, Liu Q, Ju L, et al: Reversal of sorafenib resistance in hepatocellular carcinoma: Epigenetically regulated disruption of 14-3-3η/hypoxia-inducible factor-1α. Cell Death Discov. 5:1202019. View Article : Google Scholar : PubMed/NCBI | |
Karagiota A, Kourti M, Simos G and Mylonis I: HIF-1α-derived cell-penetrating peptides inhibit ERK-dependent activation of HIF-1 and trigger apoptosis of cancer cells under hypoxia. Cell Mol Life Sci. 76:809–825. 2019. View Article : Google Scholar : PubMed/NCBI | |
Singh A, Gupta S and Sachan M: Epigenetic biomarkers in the management of ovarian cancer: Current prospectives. Front Cell Dev Biol. 7:1822019. View Article : Google Scholar : PubMed/NCBI | |
Urbano A, Smith J, Weeks RJ and Chatterjee A: Gene-specific targeting of DNA methylation in the mammalian genome. Cancers. 11:15152019. View Article : Google Scholar | |
Liu Q, Liu L, Zhao Y, Zhang J, Wang D, Chen J, He Y, Wu J, Zhang Z and Liu Z: Hypoxia induces genomic DNA demethylation through the activation of HIF-1α and transcriptional upregulation of MAT2A in hepatoma cells. Mol Cancer Ther. 10:1113–1123. 2011. View Article : Google Scholar : PubMed/NCBI | |
Han ZJ, Feng YH, Gu BH, Li YM and Chen H: The post-translational modification, SUMOylation, and cancer (Review). Int J Oncol. 52:1081–1094. 2018.PubMed/NCBI | |
Bao L, Chen Y, Lai HT, Wu SY, Wang JE, Hatanpaa KJ, Raisanen JM, Fontenot M, Lega B, Chiang CM, et al: Methylation of hypoxia-inducible factor (HIF)-1α by G9a/GLP inhibits HIF-1 transcriptional activity and cell migration. Nucleic Acids Res. 46:6576–6591. 2018. View Article : Google Scholar : PubMed/NCBI | |
Cui CP, Wong CC, Kai AK, Ho DW, Lau EY, Tsui YM, Chan LK, Cheung TT, Chok KS, Chan AC, et al: SENP1 promotes hypoxia-induced cancer stemness by HIF-1α deSUMOylation and SENP1/HIF-1α positive feedback loop. Gut. 66:2149–2159. 2017. View Article : Google Scholar : PubMed/NCBI | |
Wang X, Liang X, Liang H and Wang B: SENP1/HIF-1α feedback loop modulates hypoxia-induced cell proliferation, invasion, and EMT in human osteosarcoma cells. J Cell Biochem. 119:1819–1826. 2018. View Article : Google Scholar : PubMed/NCBI | |
Mylonis I, Kourti M, Samiotaki M, Panayotou G and Simos G: Mortalin-mediated and ERK-controlled targeting of HIF-1α to mitochondria confers resistance to apoptosis under hypoxia. J Cell Sci. 130:466–479. 2017. View Article : Google Scholar : PubMed/NCBI | |
Bullen JW, Tchernyshyov I, Holewinski RJ, DeVine L, Wu F, Venkatraman V, Kass DL, Cole RN, Van Eyk J and Semenza GL: Protein kinase A-dependent phosphorylation stimulates the transcriptional activity of hypoxia-inducible factor 1. Sci Signal. 9:ra562016. View Article : Google Scholar : PubMed/NCBI | |
Gong H, Gao S, Yu C, Li M, Liu P, Zhang G, Song J and Zheng J: Effect and mechanism of YB-1 knockdown on glioma cell growth, migration, and apoptosis. Acta Biochim Biophys Sin (Shanghai). 52:168–179. 2020. View Article : Google Scholar : PubMed/NCBI | |
El-Naggar AM, Veinotte CJ, Cheng H, Grunewald TG, Negri GL, Somasekharan SP, Corkery DP, Tirode F, Mathers J, Khan D, et al: Translational activation of HIF1α by YB-1 promotes sarcoma metastasis. Cancer Cell. 27:682–697. 2015. View Article : Google Scholar : PubMed/NCBI | |
Yu AM, Batra N, Tu MJ and Sweeney C: Novel approaches for efficient in vivo fermentation production of noncoding RNAs. Appl Microbiol Biotechnol. 104:1927–1937. 2020. View Article : Google Scholar : PubMed/NCBI | |
Panir K, Schjenken JE, Robertson SA and Hull ML: Non-coding RNAs in endometriosis: A narrative review. Hum Reprod Update. 24:497–515. 2018. View Article : Google Scholar : PubMed/NCBI | |
Liu C, Xing H, Guo C, Yang Z and Wang Y and Wang Y: MiR-124 reversed the doxorubicin resistance of breast cancer stem cells through STAT3/HIF-1 signaling pathways. Cell Cycle. 18:2215–2227. 2019. View Article : Google Scholar : PubMed/NCBI | |
Bartoszewski R, Serocki M, Janaszak-Jasiecka A, Bartoszewska S, Kochan-Jamrozy K, Piotrowski A, Króliczewski J and Collawn JF: miR-200b downregulates Krüppel Like Factor 2 (KLF2) during acute hypoxia in human endothelial cells. Eur J Cell Biol. 96:758–766. 2017. View Article : Google Scholar : PubMed/NCBI | |
Byun Y, Choi YC, Jeong Y, Lee G, Yoon S, Jeong Y, Yoon J and Baek K: MiR-200c downregulates HIF-1α and inhibits migration of lung cancer cells. Cell Mol Biol Lett. 24:282019. View Article : Google Scholar : PubMed/NCBI | |
Chen X, Wu L, Li D, Xu Y, Zhang L, Niu K, Kong R, Gu J, Xu Z, Chen Z, et al: Radiosensitizing effects of miR-18a-5p on lung cancer stem-like cells via downregulating both ATM and HIF-1α. Cancer Med. 7:3834–3847. 2018. View Article : Google Scholar : PubMed/NCBI | |
Krutilina R, Sun W, Sethuraman A, Brown M, Seagroves TN, Pfeffer LM, Ignatova T and Fan M: MicroRNA-18a inhibits hypoxia-inducible factor 1α activity and lung metastasis in basal breast cancers. Breast Cancer Res. 16:R782014. View Article : Google Scholar : PubMed/NCBI | |
Mathieu J, Zhang Z, Zhou W, Wang AJ, Heddleston JM, Pinna CM, Hubaud A, Stadler B, Choi M, Bar M, et al: HIF induces human embryonic stem cell markers in cancer cells. Cancer Res. 71:4640–4652. 2011. View Article : Google Scholar : PubMed/NCBI | |
Ho AS, Huang X, Cao H, Christman-Skieller C, Bennewith K, Le QT and Koong AC: Circulating miR-210 as a novel hypoxia marker in pancreatic cancer. Transl Oncol. 3:109–113. 2010. View Article : Google Scholar : PubMed/NCBI | |
Sabry D, El-Deek SE, Maher M, El-Baz MA, El-Bader HM, Amer E, Hassan EA, Fathy W and El-Deek HE: Role of miRNA-210, miRNA-21 and miRNA-126 as diagnostic biomarkers in colorectal carcinoma: Impact of HIF-1α-VEGF signaling pathway. Mol Cell Biochem. 454:177–189. 2019. View Article : Google Scholar : PubMed/NCBI | |
Yang W, Wei J, Guo T, Shen Y and Liu F: Knockdown of miR-210 decreases hypoxic glioma stem cells stemness and radioresistance. Exp Cell Res. 326:22–35. 2014. View Article : Google Scholar : PubMed/NCBI | |
Han M, Wang Y, Liu M, Bi X, Bao J, Zeng N, Zhu Z, Mo Z, Wu C and Chen X: MiR-21 regulates epithelial-mesenchymal transition phenotype and hypoxia-inducible factor-1α expression in third-sphere forming breast cancer stem cell-like cells. Cancer Sci. 103:1058–1064. 2012. View Article : Google Scholar : PubMed/NCBI | |
Hermansen SK, Nielsen BS, Aaberg-Jessen C and Kristensen BW: miR-21 is linked to glioma angiogenesis: A co-localization study. J Histochem Cytochem. 64:138–148. 2016. View Article : Google Scholar : PubMed/NCBI | |
Guo Y, Xiao Z, Yang L, Gao Y, Zhu Q, Hu L, Huang D and Xu Q: Hypoxia inducible factors in hepatocellular carcinoma (Review). Oncol Rep. 43:3–15. 2020.PubMed/NCBI | |
Jiang N, Zou C, Zhu Y, Luo Y, Chen L, Lei Y, Tang K, Sun Y, Zhang W, Li S, et al: HIF-1α-regulated miR-1275 maintains stem cell-like phenotypes and promotes the progression of LUAD by simultaneously activating Wnt/β-catenin and Notch signaling. Theranostics. 10:2553–2570. 2020. View Article : Google Scholar : PubMed/NCBI | |
Ge X, Liu X, Lin F, Li P, Liu K, Geng R, Dai C, Lin Y, Tang W, Wu Z, et al: MicroRNA-421 regulated by HIF-1α promotes metastasis, inhibits apoptosis, and induces cisplatin resistance by targeting E-cadherin and caspase-3 in gastric cancer. Oncotarget. 7:24466–24482. 2016. View Article : Google Scholar : PubMed/NCBI | |
Chen J, Zhou X, Xiao Q, Wang T, Shao G, Li Y and Zhang Z: MiR-107 suppresses cell proliferation and tube formation of Ewing sarcoma cells partly by targeting HIF-1β. Hum Cell. 31:42–49. 2018. View Article : Google Scholar : PubMed/NCBI | |
Yang Z, Han Y, Cheng K, Zhang G and Wang X: miR-99a directly targets the mTOR signalling pathway in breast cancer side population cells. Cell Prolif. 47:587–595. 2014. View Article : Google Scholar : PubMed/NCBI | |
Liu CJ, Tsai MM, Hung PS, Kao SY, Liu TY, Wu KJ, Chiou SH, Lin SC and Chang KW: miR-31 ablates expression of the HIF regulatory factor FIH to activate the HIF pathway in head and neck carcinoma. Cancer Res. 70:1635–1644. 2010. View Article : Google Scholar : PubMed/NCBI | |
Hung PS, Tu HF, Kao SY, Yang CC, Liu CJ, Huang TY, Chang KW and Lin SC: miR-31 is upregulated in oral premalignant epithelium and contributes to the immortalization of normal oral keratinocytes. Carcinogenesis. 35:1162–1171. 2014. View Article : Google Scholar : PubMed/NCBI | |
Chen T, Yao LQ, Shi Q, Ren Z, Ye LC, Xu JM, Zhou PH and Zhong YS: MicroRNA-31 contributes to colorectal cancer development by targeting factor inhibiting HIF-1α (FIH-1). Cancer Biol Ther. 15:516–523. 2014. View Article : Google Scholar : PubMed/NCBI | |
He J, Jin S, Zhang W, Wu D, Li J, Xu J and Gao W: Long non-coding RNA LOC554202 promotes acquired gefitinib resistance in non-small cell lung cancer through upregulating miR-31 expression. J Cancer. 10:6003–6013. 2019. View Article : Google Scholar : PubMed/NCBI | |
Zhu B, Cao X, Zhang W, Pan G, Yi Q, Zhong W and Yan D: MicroRNA-31-5p enhances the Warburg effect via targeting FIH. FASEB J. 33:545–556. 2019. View Article : Google Scholar : PubMed/NCBI | |
Kao SY, Tsai MM, Wu CH, Chen JJ, Tseng SH, Lin SC and Chang KW: Co-targeting of multiple microRNAs on factor-Inhibiting hypoxia-Inducible factor gene for the pathogenesis of head and neck carcinomas. Head Neck. 38:522–528. 2016. View Article : Google Scholar : PubMed/NCBI | |
Shih JW and Kung HJ: Long non-coding RNA and tumor hypoxia: New players ushered toward an old arena. J Biomed Sci. 24:532017. View Article : Google Scholar : PubMed/NCBI | |
Dong J, Xu J, Wang X and Jin B: Influence of the interaction between long noncoding RNAs and hypoxia on tumorigenesis. Tumour Biol. 37:1379–1385. 2016. View Article : Google Scholar : PubMed/NCBI | |
Ge H, Yan Y, Wu D, Huang Y and Tian F: Potential role of LINC00996 in colorectal cancer: A study based on data mining and bioinformatics. OncoTargets Ther. 11:4845–4855. 2018. View Article : Google Scholar | |
Yang F, Zhang H, Mei Y and Wu M: Reciprocal regulation of HIF-1α and lincRNA-p21 modulates the Warburg effect. Mol Cell. 53:88–100. 2014. View Article : Google Scholar : PubMed/NCBI | |
Shen Y, Liu Y, Sun T and Yang W: LincRNA-p21 knockdown enhances radiosensitivity of hypoxic tumor cells by reducing autophagy through HIF-1/Akt/mTOR/P70S6K pathway. Exp Cell Res. 358:188–198. 2017. View Article : Google Scholar : PubMed/NCBI | |
Shih JW, Chiang WF, Wu AT, Wu MH, Wang LY, Yu YL, Hung YW, Wang WC, Chu CY, Hung CL, et al: Long noncoding RNA LncHIFCAR/MIR31HG is a HIF-1α co-activator driving oral cancer progression. Nat Commun. 8:158742017. View Article : Google Scholar : PubMed/NCBI | |
Zhang J, Jin HY, Wu Y, Zheng ZC, Guo S, Wang Y, Yang D, Meng XY, Xu X and Zhao Y: Hypoxia-induced LncRNA PCGEM1 promotes invasion and metastasis of gastric cancer through regulating SNAI1. Clin Transl Oncol. 21:1142–1151. 2019. View Article : Google Scholar : PubMed/NCBI | |
Zhang W, Wang J, Chai R, Zhong G, Zhang C, Cao W, Yan L, Zhang X and Xu Z: Hypoxia-regulated lncRNA CRPAT4 promotes cell migration via regulating AVL9 in clear cell renal cell carcinomas. OncoTargets Ther. 11:4537–4545. 2018. View Article : Google Scholar | |
Yang W, Sun T, Cao J and Fan S: Hypoxia-inducible factor-1α downregulation by small interfering RNA inhibits proliferation, induces apoptosis, and enhances radiosensitivity in chemical hypoxic human hepatoma SMMC-7721 cells. Cancer Biother Radiopharm. 26:565–571. 2011. View Article : Google Scholar : PubMed/NCBI | |
Staab A, Fleischer M, Loeffler J, Said HM, Katzer A, Plathow C, Einsele H, Flentje M and Vordermark D: Small interfering RNA targeting HIF-1alpha reduces hypoxia-dependent transcription and radiosensitizes hypoxic HT 1080 human fibrosarcoma cells in vitro. Strahlenther Onkol. 187:252–259. 2011. View Article : Google Scholar : PubMed/NCBI | |
Yu X, Hu L, Li S, Shen J, Wang D, Xu R and Yang H: Long non-coding RNA Taurine upregulated gene 1 promotes osteosarcoma cell metastasis by mediating HIF-1α via miR-143-5p. Cell Death Dis. 10:2802019. View Article : Google Scholar : PubMed/NCBI | |
Augoff K, McCue B, Plow EF and Sossey-Alaoui K: miR-31 and its host gene lncRNA LOC554202 are regulated by promoter hypermethylation in triple-negative breast cancer. Mol Cancer. 11:52012. View Article : Google Scholar : PubMed/NCBI | |
Sun Y, Jia X, Wang M and Deng Y: Long noncoding RNA MIR31HG abrogates the availability of tumor suppressor microRNA-361 for the growth of osteosarcoma. Cancer Manag Res. 11:8055–8064. 2019. View Article : Google Scholar : PubMed/NCBI | |
Liu Y, Zhu J, Ma X, Han S, Xiao D, Jia Y and Wang Y: ceRNA network construction and comparison of gastric cancer with or without Helicobacter pylori infection. J Cell Physiol. 234:7128–7140. 2019. View Article : Google Scholar : PubMed/NCBI | |
Sun J, Yan J, Yuan X, Yang R, Dan T, Wang X, Kong G and Gao S: A computationally constructed ceRNA interaction network based on a comparison of the SHEE and SHEEC cell lines. Cell Mol Biol Lett. 21:212016. View Article : Google Scholar : PubMed/NCBI | |
Zhang Q, Cheng Q, Xia M, Huang X, He X and Liao J: Hypoxia-induced lncRNA-NEAT1 sustains the growth of hepatocellular carcinoma via regulation of miR-199a-3p/UCK2. Front Oncol. 10:9982020. View Article : Google Scholar : PubMed/NCBI | |
van Schaijik B, Davis PF, Wickremesekera AC, Tan ST and Itinteang T: Subcellular localisation of the stem cell markers OCT4, SOX2, NANOG, KLF4 and c-MYC in cancer: A review. J Clin Pathol. 71:88–91. 2018. View Article : Google Scholar : PubMed/NCBI | |
Wang Z and Zöller M: Exosomes, metastases, and the miracle of cancer stem cell markers. Cancer Metastasis Rev. 38:259–295. 2019. View Article : Google Scholar : PubMed/NCBI | |
Lin YT and Wu KJ: Epigenetic regulation of epithelial-mesenchymal transition: Focusing on hypoxia and TGF-β signaling. J Biomed Sci. 27:392020. View Article : Google Scholar : PubMed/NCBI | |
Rankin EB, Nam JM and Giaccia AJ: Hypoxia: Signaling the metastatic cascade. Trends Cancer. 2:295–304. 2016. View Article : Google Scholar : PubMed/NCBI | |
Hajizadeh F, Okoye I, Esmaily M, Ghasemi Chaleshtari M, Masjedi A, Azizi G, Irandoust M, Ghalamfarsa G and Jadidi-Niaragh F: Hypoxia inducible factors in the tumor microenvironment as therapeutic targets of cancer stem cells. Life Sci. 237:1169522019. View Article : Google Scholar : PubMed/NCBI | |
Zhang H, Lu H, Xiang L, Bullen JW, Zhang C, Samanta D, Gilkes DM, He J and Semenza GL: HIF-1 regulates CD47 expression in breast cancer cells to promote evasion of phagocytosis and maintenance of cancer stem cells. Proc Natl Acad Sci USA. 112:E6215–E6223. 2015. View Article : Google Scholar : PubMed/NCBI | |
Thomas S, Harding MA, Smith SC, Overdevest JB, Nitz MD, Frierson HF, Tomlins SA, Kristiansen G and Theodorescu D: CD24 is an effector of HIF-1-driven primary tumor growth and metastasis. Cancer Res. 72:5600–5612. 2012. View Article : Google Scholar : PubMed/NCBI | |
Ohnishi S, Maehara O, Nakagawa K, Kameya A, Otaki K, Fujita H, Higashi R, Takagi K, Asaka M, Sakamoto N, et al: hypoxia-inducible factors activate CD133 promoter through ETS family transcription factors. PLoS One. 8:e662552013. View Article : Google Scholar : PubMed/NCBI | |
Hashimoto O, Shimizu K, Semba S, Chiba S, Ku Y, Yokozaki H and Hori Y: Hypoxia induces tumor aggressiveness and the expansion of CD133-positive cells in a hypoxia-inducible factor-1alpha-dependent manner in pancreatic cancer cells. Pathobiology. 78:181–192. 2011. View Article : Google Scholar : PubMed/NCBI | |
Chiu DK, Zhang MS, Tse AP and Wong CC: Assessment of stabilization and activity of the HIFs important for hypoxia-induced signalling in cancer cells. Methods Mol Biol. 1928:77–99. 2019. View Article : Google Scholar : PubMed/NCBI | |
Soeda A, Park M, Lee D, Mintz A, Androutsellis-Theotokis A, McKay RD, Engh J, Iwama T, Kunisada T, Kassam AB, et al: Hypoxia promotes expansion of the CD133-positive glioma stem cells through activation of HIF-1alpha. Oncogene. 28:3949–3959. 2009. View Article : Google Scholar : PubMed/NCBI | |
Hashimoto K, Aoyagi K, Isobe T, Kouhuji K and Shirouzu K: Expression of CD133 in the cytoplasm is associated with cancer progression and poor prognosis in gastric cancer. Gastric Cancer. 17:97–106. 2014. View Article : Google Scholar : PubMed/NCBI | |
Maeda K, Ding Q, Yoshimitsu M, Kuwahata T, Miyazaki Y, Tsukasa K, Hayashi T, Shinchi H, Natsugoe S and Takao S: CD133 modulate HIF-1alpha expression under hypoxia in EMT phenotype pancreatic cancer stem-like cells. Int J Mol Sci. 17:10252016. View Article : Google Scholar | |
Matsumoto K, Arao T, Tanaka K, Kaneda H, Kudo K, Fujita Y, Tamura D, Aomatsu K, Tamura T, Yamada Y, et al: mTOR signal and hypoxia-inducible factor-1 alpha regulate CD133 expression in cancer cells. Cancer Res. 69:7160–7164. 2009. View Article : Google Scholar : PubMed/NCBI | |
Li SW, Wu XL, Dong CL, Xie XY, Wu JF and Zhang X: The differential expression of OCT4 isoforms in cervical carcinoma. PLoS One. 10:e01180332015. View Article : Google Scholar : PubMed/NCBI | |
Ciccone V, Terzuoli E, Donnini S, Giachetti A, Morbidelli L and Ziche M: Stemness marker ALDH1A1 promotes tumor angiogenesis via retinoic acid/HIF-1α/VEGF signalling in MCF-7 breast cancer cells. J Exp Clin Cancer Res. 37:3112018. View Article : Google Scholar : PubMed/NCBI | |
Chen Y, Xu H, Shi Q, Gu M, Wan X, Chen Q and Wang Z: Hypoxia-inducible factor 1α (HIF-1α) mediates the epithelial-mesenchymal transition in benign prostatic hyperplasia. Int J Clin Exp Pathol. 12:295–304. 2019.PubMed/NCBI | |
Abouhashem NS, Ibrahim DA and Mohamed AM: Prognostic implications of epithelial to mesenchymal transition related proteins (E-cadherin, Snail) and hypoxia inducible factor 1α in endometrioid endometrial carcinoma. Ann Diagn Pathol. 22:1–11. 2016. View Article : Google Scholar : PubMed/NCBI | |
Lee SY, Ju MK, Jeon HM, Lee YJ, Kim CH, Park HG, Han SI and Kang HS: Oncogenic metabolism acts as a prerequisite step for induction of cancer metastasis and cancer stem cell phenotype. Oxid Med Cell Longev. 2018:10274532018. View Article : Google Scholar : PubMed/NCBI | |
Kouvaras E, Christoni Z, Siasios I, Malizos K, Koukoulis GK and Ioannou M: Hypoxia-inducible factor 1-alpha and vascular endothelial growth factor in cartilage tumors. Biotech Histochem. 94:283–289. 2019. View Article : Google Scholar : PubMed/NCBI | |
Chabi S, Uzan B, Naguibneva I, Rucci J, Fahy L, Calvo J, Arcangeli ML, Mazurier F, Pflumio F and Haddad R: Hypoxia regulates lymphoid development of human hematopoietic progenitors. Cell Rep. 29:2307–2320.e6. 2019. View Article : Google Scholar : PubMed/NCBI | |
Barsoum IB, Smallwood CA, Siemens DR and Graham CH: A mechanism of hypoxia-mediated escape from adaptive immunity in cancer cells. Cancer Res. 74:665–674. 2014. View Article : Google Scholar : PubMed/NCBI | |
Polke M, Seiler F, Lepper PM, Kamyschnikow A, Langer F, Monz D, Herr C, Bals R and Beisswenger C: Hypoxia and the hypoxia-regulated transcription factor HIF-1α suppress the host defence of airway epithelial cells. Innate Immun. 23:373–380. 2017. View Article : Google Scholar : PubMed/NCBI | |
Flück K, Breves G, Fandrey J and Winning S: Hypoxia-inducible factor 1 in dendritic cells is crucial for the activation of protective regulatory T cells in murine colitis. Mucosal Immunol. 9:379–390. 2016. View Article : Google Scholar : PubMed/NCBI | |
Sun X, Kanwar JR, Leung E, Lehnert K, Wang D and Krissansen GW: Gene transfer of antisense hypoxia inducible factor-1 alpha enhances the therapeutic efficacy of cancer immunotherapy. Gene Ther. 8:638–645. 2001. View Article : Google Scholar : PubMed/NCBI | |
Liu F, Wang P, Jiang X, Tan G, Qiao H, Jiang H, Krissansen GW and Sun X: Antisense hypoxia-inducible factor 1alpha gene therapy enhances the therapeutic efficacy of doxorubicin to combat hepatocellular carcinoma. Cancer Sci. 99:2055–2061. 2008.PubMed/NCBI | |
Tartour E, Pere H, Maillere B, Terme M, Merillon N, Taieb J, Sandoval F, Quintin-Colonna F, Lacerda K, Karadimou A, et al: Angiogenesis and immunity: A bidirectional link potentially relevant for the monitoring of antiangiogenic therapy and the development of novel therapeutic combination with immunotherapy. Cancer Metastasis Rev. 30:83–95. 2011. View Article : Google Scholar : PubMed/NCBI | |
Wei J, Wu A, Kong LY, Wang Y, Fuller G, Fokt I, Melillo G, Priebe W and Heimberger AB: Hypoxia potentiates glioma-mediated immunosuppression. PLoS One. 6:e161952011. View Article : Google Scholar : PubMed/NCBI | |
Wu A, Wei J, Kong LY, Wang Y, Priebe W, Qiao W, Sawaya R and Heimberger AB: Glioma cancer stem cells induce immunosuppressive macrophages/microglia. Neuro Oncol. 12:1113–1125. 2010. View Article : Google Scholar : PubMed/NCBI | |
Wei J, Barr J, Kong LY, Wang Y, Wu A, Sharma AK, Gumin J, Henry V, Colman H, Priebe W, et al: Glioblastoma cancer-initiating cells inhibit T-cell proliferation and effector responses by the signal transducers and activators of transcription 3 pathway. Mol Cancer Ther. 9:67–78. 2010. View Article : Google Scholar : PubMed/NCBI | |
Ye LY, Chen W, Bai XL, Xu XY, Zhang Q, Xia XF, Sun X, Li GG, Hu QD, Fu QH, et al: Hypoxia-induced epithelial-to-Mesenchymal transition in hepatocellular carcinoma induces an immunosuppressive tumor microenvironment to promote metastasis. Cancer Res. 76:818–830. 2016. View Article : Google Scholar : PubMed/NCBI | |
Noman MZ, Hasmim M, Messai Y, Terry S, Kieda C, Janji B and Chouaib S: Hypoxia: A key player in antitumor immune response. A review in the theme: Cellular responses to hypoxia. Am J Physiol Cell Physiol. 309:C569–C579. 2015. View Article : Google Scholar : PubMed/NCBI | |
Guo X, Xue H, Shao Q, Wang J, Guo X, Chen X, Zhang J, Xu S, Li T, Zhang P, et al: Hypoxia promotes glioma-associated macrophage infiltration via periostin and subsequent M2 polarization by upregulating TGF-beta and M-CSFR. Oncotarget. 7:80521–80542. 2016. View Article : Google Scholar : PubMed/NCBI | |
Yu X, Li Z, Zhang Y, Xu M, Che Y, Tian X, Wang R, Zou K and Zou L: β-elemene inhibits radiation and hypoxia-induced macrophages infiltration via Prx-1/NF-κB/HIF-1α signaling pathway. OncoTargets Ther. 12:4203–4211. 2019. View Article : Google Scholar | |
Cecil DL, Slota M, O'Meara MM, Curtis BC, Gad E, Dang Y, Herendeen D, Rastetter L and Disis ML: Immunization against HIF-1α inhibits the growth of basal mammary tumors and targets mammary stem cells in vivo. Clin Cancer Res. 23:3396–3404. 2017. View Article : Google Scholar : PubMed/NCBI | |
de Almeida PE, Mak J, Hernandez G, Jesudason R, Herault A, Javinal V, Borneo J, Kim JM and Walsh KB: Anti-VEGF treatment enhances CD8+ T-cell antitumor activity by amplifying hypoxia. Cancer Immunol Res. 8:806–818. 2020. View Article : Google Scholar : PubMed/NCBI | |
Hasmim M, Noman MZ, Lauriol J, Benlalam H, Mallavialle A, Rosselli F, Mami-Chouaib F, Alcaide-Loridan C and Chouaib S: Hypoxia-dependent inhibition of tumor cell susceptibility to CTL-mediated lysis involves NANOG induction in target cells. J Immunol. 187:4031–4039. 2011. View Article : Google Scholar : PubMed/NCBI | |
Hasmim M, Noman MZ, Messai Y, Bordereaux D, Gros G, Baud V and Chouaib S: Cutting edge: Hypoxia-induced Nanog favors the intratumoral infiltration of regulatory T cells and macrophages via direct regulation of TGF-β1. J Immunol. 191:5802–5806. 2013. View Article : Google Scholar : PubMed/NCBI | |
Nam K, Oh S and Shin I: Ablation of CD44 induces glycolysis-to-oxidative phosphorylation transition via modulation of the c-Src-Akt-LKB1-AMPKα pathway. Biochem J. 473:3013–3030. 2016. View Article : Google Scholar : PubMed/NCBI | |
Moldogazieva NT, Mokhosoev IM and Terentiev AA: Metabolic heterogeneity of cancer cells: An interplay between HIF-1, GLUTs, and AMPK. Cancers (Basel). 12:8622020. View Article : Google Scholar | |
Semenza GL: Hypoxia-inducible factors: Coupling glucose metabolism and redox regulation with induction of the breast cancer stem cell phenotype. EMBO J. 36:252–259. 2017. View Article : Google Scholar : PubMed/NCBI | |
Kuo CY, Cheng CT, Hou P, Lin YP, Ma H, Chung Y, Chi K, Chen Y, Li W, Kung HJ, et al: HIF-1-alpha links mitochondrial perturbation to the dynamic acquisition of breast cancer tumorigenicity. Oncotarget. 7:34052–34069. 2016. View Article : Google Scholar : PubMed/NCBI | |
Deshmukh A, Deshpande K, Arfuso F, Newsholme P and Dharmarajan A: Cancer stem cell metabolism: A potential target for cancer therapy. Mol Cancer. 15:692016. View Article : Google Scholar : PubMed/NCBI | |
Shen YA, Pan SC, Chu I, Lai RY and Wei YH: Targeting cancer stem cells from a metabolic perspective. Exp Biol Med (Maywood). 245:465–476. 2020. View Article : Google Scholar : PubMed/NCBI | |
Lai HT, Chiang CT, Tseng WK, Chao TC and Su Y: GATA6 enhances the stemness of human colon cancer cells by creating a metabolic symbiosis through upregulating LRH-1 expression. Mol Oncol. 14:1327–1347. 2020. View Article : Google Scholar : PubMed/NCBI | |
Song KH, Kim JH, Lee YH, Bae HC, Lee HJ, Woo SR, Oh SJ, Lee KM, Yee C, Kim BW, et al: Mitochondrial reprogramming via ATP5H loss promotes multimodal cancer therapy resistance. J Clin Invest. 128:4098–4114. 2018. View Article : Google Scholar : PubMed/NCBI | |
Tang K, Yu Y, Zhu L, Xu P, Chen J, Ma J, Zhang H, Fang H, Sun W, Zhou L, et al: Hypoxia-reprogrammed tricarboxylic acid cycle promotes the growth of human breast tumorigenic cells. Oncogene. 38:6970–6984. 2019. View Article : Google Scholar : PubMed/NCBI | |
Patra K, Jana S, Sarkar A, Mandal DP and Bhattacharjee S: The inhibition of hypoxia-induced angiogenesis and metastasis by cinnamaldehyde is mediated by decreasing HIF-1α protein synthesis via PI3K/Akt pathway. Biofactors. 45:401–415. 2019. View Article : Google Scholar : PubMed/NCBI | |
Marhold M, Tomasich E, El-Gazzar A, Heller G, Spittler A, Horvat R, Krainer M and Horak P: HIF1α regulates mTOR signaling and viability of prostate cancer stem cells. Mol Cancer Res. 13:556–564. 2015. View Article : Google Scholar : PubMed/NCBI | |
Jung J, Zhang Y, Celiku O, Zhang W, Song H, Williams BJ, Giles AJ, Rich JN, Abounader R, Gilbert MR, et al: Mitochondrial NIX promotes tumor survival in the hypoxic niche of glioblastoma. Cancer Res. 79:5218–5232. 2019. View Article : Google Scholar : PubMed/NCBI | |
Lv Z, Liu RD, Chen XQ, Wang B, Li LF, Guo YS, Chen XJ and Ren XQ: HIF 1α promotes the stemness of oesophageal squamous cell carcinoma by activating the Wnt/β catenin pathway. Oncol Rep. 42:726–734. 2019.PubMed/NCBI | |
Xiang L, Gilkes DM, Hu H, Luo W, Bullen JW, Liang H and Semenza GL: HIF-1α and TAZ serve as reciprocal co-activators in human breast cancer cells. Oncotarget. 6:11768–11778. 2015. View Article : Google Scholar : PubMed/NCBI | |
Zhang L, Shi H, Chen H, Gong A, Liu Y, Song L, Xu X, You T, Fan X, Wang D, et al: Dedifferentiation process driven by radiotherapy-induced HMGB1/TLR2/YAP/HIF-1α signaling enhances pancreatic cancer stemness. Cell Death Dis. 10:7242019. View Article : Google Scholar : PubMed/NCBI | |
Qian J and Rankin EB: Hypoxia-induced phenotypes that mediate tumor heterogeneity. Adv Exp Med Biol. 1136:43–55. 2019. View Article : Google Scholar : PubMed/NCBI | |
Luo M, Shang L, Brooks MD, Jiagge E, Zhu Y, Buschhaus JM, Conley S, Fath MA, Davis A, Gheordunescu E, et al: Targeting breast cancer stem cell state equilibrium through modulation of redox signaling. Cell Metab. 28:69–86.e6. 2018. View Article : Google Scholar : PubMed/NCBI | |
Wang Y and Liu Y, Malek SN, Zheng P and Liu Y: Targeting HIF1α eliminates cancer stem cells in hematological malignancies. Cell Stem Cell. 8:399–411. 2011. View Article : Google Scholar : PubMed/NCBI | |
Hirata H, Yoshiura S, Ohtsuka T, Bessho Y, Harada T, Yoshikawa K and Kageyama R: Oscillatory expression of the bHLH factor Hes1 regulated by a negative feedback loop. Science. 298:840–843. 2002. View Article : Google Scholar : PubMed/NCBI | |
Almiron Bonnin DA, Havrda MC, Lee MC, Liu H, Zhang Z, Nguyen LN, Harrington LX, Hassanpour S, Cheng C and Israel MA: Secretion-mediated STAT3 activation promotes self-renewal of glioma stem-like cells during hypoxia. Oncogene. 37:1107–1118. 2018. View Article : Google Scholar : PubMed/NCBI | |
Zhang L, Huang G, Li X, Zhang Y, Jiang Y, Shen J, Liu J, Wang Q, Zhu J, Feng X, et al: Hypoxia induces epithelial-mesenchymal transition via activation of SNAI1 by hypoxia-inducible factor −1α in hepatocellular carcinoma. BMC Cancer. 13:1082013. View Article : Google Scholar : PubMed/NCBI | |
Yang SW, Zhang ZG, Hao YX, Zhao YL, Qian F, Shi Y, Li PA, Liu CY and Yu PW: HIF-1α induces the epithelial-mesenchymal transition in gastric cancer stem cells through the Snail pathway. Oncotarget. 8:9535–9545. 2017. View Article : Google Scholar : PubMed/NCBI | |
Du J, Sun B, Zhao X, Gu Q, Dong X, Mo J, Sun T, Wang J, Sun R and Liu Y: Hypoxia promotes vasculogenic mimicry formation by inducing epithelial-mesenchymal transition in ovarian carcinoma. Gynecol Oncol. 133:575–583. 2014. View Article : Google Scholar : PubMed/NCBI | |
Lu H, Tran L, Park Y, Chen I, Lan J, Xie Y and Semenza GL: Reciprocal regulation of DUSP9 and DUSP16 expression by HIF1 controls ERK and p38 MAP kinase activity and mediates chemotherapy-induced breast cancer stem cell enrichment. Cancer Res. 78:4191–4202. 2018. View Article : Google Scholar : PubMed/NCBI | |
Bhuria V, Xing J, Scholta T, Bui KC, Nguyen MLT, Malek NP, Bozko P and Plentz RR: Hypoxia induced Sonic Hedgehog signaling regulates cancer stemness, epithelial-to-mesenchymal transition and invasion in cholangiocarcinoma. Exp Cell Res. 385:1116712019. View Article : Google Scholar : PubMed/NCBI | |
Lv L, Yang Z, Ma T and Xuan Y: Gli1, a potential cancer stem cell marker, is strongly associated with prognosis in prostate cancer. Int J Clin Exp Pathol. 11:4957–4966. 2018.PubMed/NCBI | |
Qin J, Liu Y, Lu Y, Liu M, Li M, Li J and Wu L: Hypoxia-inducible factor 1 alpha promotes cancer stem cells-like properties in human ovarian cancer cells by upregulating SIRT1 expression. Sci Rep. 7:105922017. View Article : Google Scholar : PubMed/NCBI | |
Guan Z, Ding C, Du Y, Zhang K, Zhu JN, Zhang T, He D, Xu S, Wang X and Fan J: HAF drives the switch of HIF-1α to HIF-2α by activating the NF-κB pathway, leading to malignant behavior of T24 bladder cancer cells. Int J Oncol. 44:393–402. 2014. View Article : Google Scholar : PubMed/NCBI | |
Mendonça DB, Mendonça G, Aragão FJ and Cooper LF: NF-κB suppresses HIF-1α response by competing for P300 binding. Biochem Biophys Res Commun. 404:997–1003. 2011. View Article : Google Scholar : PubMed/NCBI | |
Zhang Y, Jiang X, Qin X, Ye D, Yi Z, Liu M, Bai O, Liu W, Xie X, Wang Z, et al: RKTG inhibits angiogenesis by suppressing MAPK-mediated autocrine VEGF signaling and is downregulated in clear-cell renal cell carcinoma. Oncogene. 29:5404–5415. 2010. View Article : Google Scholar : PubMed/NCBI | |
Roth U, Curth K, Unterman TG and Kietzmann T: The transcription factors HIF-1 and HNF-4 and the coactivator p300 are involved in insulin-regulated glucokinase gene expression via the phosphatidylinositol 3-kinase/protein kinase B pathway. J Biol Chem. 279:2623–2631. 2004. View Article : Google Scholar : PubMed/NCBI | |
Niu F, Li Y, Lai FF, Ni L, Ji M, Jin J, Yang HZ, Wang C, Zhang DM and Chen XG: LB-1 exerts antitumor activity in pancreatic cancer by inhibiting HIF-1α and Stat3 signaling. J Cell Physiol. 230:2212–2223. 2015. View Article : Google Scholar : PubMed/NCBI | |
Kida A and Kahn M: Hypoxia selects for a quiescent, CML stem/leukemia initiating-like population dependent on CBP/catenin transcription. Curr Mol Pharmacol. 6:204–210. 2013. View Article : Google Scholar : PubMed/NCBI | |
Bordonaro M and Lazarova DL: CREB-binding protein, p300, butyrate, and Wnt signaling in colorectal cancer. World J Gastroenterol. 21:8238–8248. 2015. View Article : Google Scholar : PubMed/NCBI | |
Yoon H, Lim JH, Cho CH, Huang LE and Park JW: CITED2 controls the hypoxic signaling by snatching p300 from the two distinct activation domains of HIF-1α. Biochim Biophys Acta. 1813:2008–2016. 2011. View Article : Google Scholar : PubMed/NCBI | |
Jin P, Kang J, Lee MK and Park JW: Ferritin heavy chain controls the HIF-driven hypoxic response by activating the asparaginyl hydroxylase FIH. Biochem Biophys Res Commun. 499:475–481. 2018. View Article : Google Scholar : PubMed/NCBI | |
Lee GY, Shin SH, Shin HW, Chun YS and Park JW: NDRG3 lowers the metastatic potential in prostate cancer as a feedback controller of hypoxia-inducible factors. Exp Mol Med. 50:1–13. 2018. View Article : Google Scholar | |
Papale M, Buccarelli M, Mollinari C, Russo MA, Pallini R, Ricci-Vitiani L and Tafani M: Hypoxia, inflammation and necrosis as determinants of glioblastoma cancer stem cells progression. Int J Mol Sci. 21:26602020. View Article : Google Scholar | |
Kessler J, Hahnel A, Wichmann H, Rot S, Kappler M, Bache M and Vordermark D: HIF-1α inhibition by siRNA or chetomin in human malignant glioma cells: Effects on hypoxic radioresistance and monitoring via CA9 expression. BMC Cancer. 10:6052010. View Article : Google Scholar : PubMed/NCBI | |
Lo WL, Chien Y, Chiou GY, Tseng LM, Hsu HS, Chang YL, Lu KH, Chien CS, Wang ML, Chen YW, et al: Nuclear localization signal-enhanced RNA interference of EZH2 and Oct4 in the eradication of head and neck squamous cell carcinoma-derived cancer stem cells. Biomaterials. 33:3693–3709. 2012. View Article : Google Scholar : PubMed/NCBI | |
Li SH, Shin DH, Chun YS, Lee MK, Kim MS and Park JW: A novel mode of action of YC-1 in HIF inhibition: Stimulation of FIH-dependent p300 dissociation from HIF-1{alpha}. Mol Cancer Ther. 7:3729–3738. 2008. View Article : Google Scholar : PubMed/NCBI | |
Shin DH, Chun YS, Lee DS, Huang LE and Park JW: Bortezomib inhibits tumor adaptation to hypoxia by stimulating the FIH-mediated repression of hypoxia-inducible factor-1. Blood. 111:3131–3136. 2008. View Article : Google Scholar : PubMed/NCBI | |
Yang C, Wang W, Li GD, Zhong HJ, Dong ZZ, Wong CY, Kwong DW, Ma DL and Leung CH: Anticancer osmium complex inhibitors of the HIF-1α and p300 protein-protein interaction. Sci Rep. 7:428602017. View Article : Google Scholar : PubMed/NCBI | |
Fernandez EV, Reece KM, Ley AM, Troutman SM, Sissung TM, Price DK, Chau CH and Figg WD: Dual targeting of the androgen receptor and hypoxia-inducible factor 1α pathways synergistically inhibits castration-resistant prostate cancer cells. Mol Pharmacol. 87:1006–1012. 2015. View Article : Google Scholar : PubMed/NCBI | |
Goradel NH, Asghari MH, Moloudizargari M, Negahdari B, Haghi-Aminjan H and Abdollahi M: Melatonin as an angiogenesis inhibitor to combat cancer: Mechanistic evidence. Toxicol Appl Pharmacol. 335:56–63. 2017. View Article : Google Scholar : PubMed/NCBI | |
Harris EM, Strope JD, Beedie SL, Huang PA, Goey AK, Cook KM, Schofield CJ, Chau CH, Cadelis MM, Copp BR, et al: Preclinical evaluation of discorhabdins in antiangiogenic and antitumor models. Mar Drugs. 16:2412018. View Article : Google Scholar | |
Chen H, Guan Y, Yuan G, Zhang Q and Jing N: A perylene derivative regulates HIF-1α and Stat3 signaling pathways. Bioorg Med Chem. 22:1496–1505. 2014. View Article : Google Scholar : PubMed/NCBI | |
McGinn O, Gupta VK, Dauer P, Arora N, Sharma N, Nomura A, Dudeja V, Saluja A and Banerjee S: Inhibition of hypoxic response decreases stemness and reduces tumorigenic signaling due to impaired assembly of HIF1 transcription complex in pancreatic cancer. Sci Rep. 7:78722017. View Article : Google Scholar : PubMed/NCBI | |
Wang T, Shigdar S, Gantier MP, Hou Y, Wang L, Li Y, Shamaileh HA, Yin W, Zhou SF, Zhao X, et al: Cancer stem cell targeted therapy: Progress amid controversies. Oncotarget. 6:44191–44206. 2015. View Article : Google Scholar : PubMed/NCBI | |
Xiang L and Semenza GL: Hypoxia-inducible factors promote breast cancer stem cell specification and maintenance in response to hypoxia or cytotoxic chemotherapy. Adv Cancer Res. 141:175–212. 2019. View Article : Google Scholar : PubMed/NCBI | |
Yeo CD, Kang N, Choi SY, Kim BN, Park CK, Kim JW, Kim YK and Kim SJ: The role of hypoxia on the acquisition of epithelial-mesenchymal transition and cancer stemness: A possible link to epigenetic regulation. Korean J Intern Med. 32:589–599. 2017. View Article : Google Scholar : PubMed/NCBI | |
Lee JH, Hur W, Hong SW, Kim JH, Kim SM, Lee EB and Yoon SK: ELK3 promotes the migration and invasion of liver cancer stem cells by targeting HIF-1α. Oncol Rep. 37:813–822. 2017. View Article : Google Scholar : PubMed/NCBI |