Interaction between cyclooxygenase-2 and insulin-like growth factor in breast cancer: A new field for prevention and treatment

  • Authors:
    • Giuliana Cássia Morrone Taromaru
    • Vilmar Marques de Oliveira
    • Maria  Antonieta Longo Galvão Silva
    • Wagner Ricardo Montor
    • Fabio Bagnoli
    • José Francisco Rinaldi
    • Tsutomu Aoki
  • View Affiliations

  • Published online on: December 21, 2011     https://doi.org/10.3892/ol.2011.532
  • Pages: 682-688
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Abstract

The objective of this study was to evaluate the correlation between cyclooxygenase-2 (COX-2) and markers of cell proliferation and apoptosis, including, Bcl-2, Bax, Ki-67 and the type I insulin-like growth factor (IGF) receptor (IGF1-R) in ductal carcinoma in situ (DCIS) and infiltrating ductal carcinoma (IDC), present in the same surgical specimen. A total of 110 cases were evaluated using tissue microarrays. Cases were classified in scores from 0 to 3 according to pre-defined methods. The results showed that the positivity rates were COX-2 in 87% of cases in DCIS and IDC; Bcl-2 in 55% of cases in DCIS and IDC; Bax in 23% of cases in IDC and 19% in DCIS, IGF-1 in 24% of cases in DCIS and IDC; and Ki-67 in 81% of cases in DCIS and IDC. We also observed a positive correlation between the expression of COX-2 and IGF1-R (p=0.045). Our results demonstrate a positive correlation between the expression of COX-2 and IGF1-R in DCIS and IDC, demonstrating that they are involved in breast cancer carcinogenesis. Further studies are required to prove the effectiveness of COX-2 and IGF1-R inhibitors for the prevention and treatment of breast cancer, as well as to explain their mechanism of action.
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March 2012
Volume 3 Issue 3

Print ISSN: 1792-1074
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Spandidos Publications style
Morrone Taromaru GC, Marques de Oliveira V, Longo Galvão Silva MA, Montor WR, Bagnoli F, Rinaldi JF and Aoki T: Interaction between cyclooxygenase-2 and insulin-like growth factor in breast cancer: A new field for prevention and treatment. Oncol Lett 3: 682-688, 2012.
APA
Morrone Taromaru, G.C., Marques de Oliveira, V., Longo Galvão Silva, M.A., Montor, W.R., Bagnoli, F., Rinaldi, J.F., & Aoki, T. (2012). Interaction between cyclooxygenase-2 and insulin-like growth factor in breast cancer: A new field for prevention and treatment. Oncology Letters, 3, 682-688. https://doi.org/10.3892/ol.2011.532
MLA
Morrone Taromaru, G. C., Marques de Oliveira, V., Longo Galvão Silva, M. A., Montor, W. R., Bagnoli, F., Rinaldi, J. F., Aoki, T."Interaction between cyclooxygenase-2 and insulin-like growth factor in breast cancer: A new field for prevention and treatment". Oncology Letters 3.3 (2012): 682-688.
Chicago
Morrone Taromaru, G. C., Marques de Oliveira, V., Longo Galvão Silva, M. A., Montor, W. R., Bagnoli, F., Rinaldi, J. F., Aoki, T."Interaction between cyclooxygenase-2 and insulin-like growth factor in breast cancer: A new field for prevention and treatment". Oncology Letters 3, no. 3 (2012): 682-688. https://doi.org/10.3892/ol.2011.532