STAT3, p‑STAT3 and HIF‑1α are associated with vasculogenic mimicry and impact on survival in gastric adenocarcinoma

  • Authors:
    • Yan‑Yan Song
    • Li‑Dan Sun
    • Min‑Li Liu
    • Zhong‑Liang Liu
    • Fei Chen
    • Ying‑Zhe Zhang
    • Yan Zheng
    • Jian‑Ping Zhang
  • View Affiliations

  • Published online on: April 11, 2014     https://doi.org/10.3892/ol.2014.2059
  • Pages: 431-437
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Abstract

Vasculogenic mimicry (VM) formation is important for invasion and metastasis of tumor cells in gastric adenocarcinoma (GAC). The present study aimed to investigate the association between signal transducer and activator of transcription‑3 (STAT3), phosphor‑STAT3 (p‑STAT3), hypoxia‑inducible factor‑1α (HIF‑1α) and VM formation in GAC, and discuss their clinical significance and correlation with the prognosis of patients with GAC. The expression levels of STAT3, p‑STAT3, HIF‑1α and VM were assessed in 60 cases of patients with GAC and 20 cases of patients with gastritis on tissue microarrays by immunohistochemical methods. The expression levels of STAT3, p‑STAT3, HIF‑1α and VM were higher in patients with GAC (particularly in poorly differentiated GAC) than in those with gastritis (P<0.05). The expression levels of STAT3, p‑STAT3 and HIF‑1α were higher in VM tissues compared with non‑VM tissues (P<0.05). Positive correlations existed between STAT3, p‑STAT3, HIF‑1α and VM expression (P<0.05). The expression levels of STAT3, p‑STAT3 and HIF‑1α, VM, status of lymph node metastasis and tumor differentiation degree were associated with the overall survival time of patients with GAC (P<0.05). However, only p‑STAT3 and VM expression were identified as the independent risk factors of GAC OS when analyzed with multivariate analysis. p‑STAT3 and VM play a significant role in indicating the prognosis of patients with GAC. STAT3 activation may play a positive role in VM formation of GAC by the STAT3‑p‑STAT3‑HIF‑1α‑VM effect axis.
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July-2014
Volume 8 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Song YY, Sun LD, Liu ML, Liu ZL, Chen F, Zhang YZ, Zheng Y and Zhang JP: STAT3, p‑STAT3 and HIF‑1α are associated with vasculogenic mimicry and impact on survival in gastric adenocarcinoma. Oncol Lett 8: 431-437, 2014.
APA
Song, Y., Sun, L., Liu, M., Liu, Z., Chen, F., Zhang, Y. ... Zhang, J. (2014). STAT3, p‑STAT3 and HIF‑1α are associated with vasculogenic mimicry and impact on survival in gastric adenocarcinoma. Oncology Letters, 8, 431-437. https://doi.org/10.3892/ol.2014.2059
MLA
Song, Y., Sun, L., Liu, M., Liu, Z., Chen, F., Zhang, Y., Zheng, Y., Zhang, J."STAT3, p‑STAT3 and HIF‑1α are associated with vasculogenic mimicry and impact on survival in gastric adenocarcinoma". Oncology Letters 8.1 (2014): 431-437.
Chicago
Song, Y., Sun, L., Liu, M., Liu, Z., Chen, F., Zhang, Y., Zheng, Y., Zhang, J."STAT3, p‑STAT3 and HIF‑1α are associated with vasculogenic mimicry and impact on survival in gastric adenocarcinoma". Oncology Letters 8, no. 1 (2014): 431-437. https://doi.org/10.3892/ol.2014.2059