Null genotypes of glutathione S-transferase µ1 and glutathione S-transferase θ1 are associated with osteosarcoma risk: A meta-analysis

Han,Jicheng; Deng,Wei; Wang,Laiying; Qi,Wanli

doi:10.3892/ol.2015.2955

Null genotypes of glutathione S-transferase µ1 and glutathione S-transferase θ1 are associated with osteosarcoma risk: A meta-analysis

Authors:
- Jicheng Han
- Wei Deng
- Laiying Wang
- Wanli Qi
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Affiliations: Department of Orthopaedics, The Affiliated Hospital to Changchun University of Chinese Medicine, Changchun, Jilin 130000, P.R. China
Published online on: February 10, 2015 https://doi.org/10.3892/ol.2015.2955
Pages: 1912-1916

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Abstract

Glutathione S‑transferase (GST) genetic polymorphisms has been reported to be associated with osteosarcoma; however, the results of previous studies are conflicting. Thus, in the present study, a meta‑analysis was conducted to investigate the effects of GSTM1 and GSTT1 polymorphisms on osteosarcoma risk. A literature search was performed in the PubMed, Cochrane Library and China National Knowledge Infrastructure databases to identify case‑control studies published prior to March 2014. Data were extracted and pooled odds ratios (OR) with 95% confidence intervals (CI) were calculated. In addition, Begg's test was used to measure publication bias. Sensitivity analysis were performed to ensure the accuracy of the results. The meta‑analysis results demonstrated no significant association between the null genotype of GSTM1 and osteosarcoma risk (OR=0.83; 95% CI, 0.37‑1.85). By contrast, the results revealed a significant association for the comparison of null vs. non‑null genotypes of GSTT1 (OR=1.54; 95% CI, 1.09‑2.19). In conclusion, the GSTT1 null genotype may be associated with an increased risk of developing osteosarcoma. Further studies with larger sample sizes and well‑designed methodologies are required to verify these conclusions.

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