Compound gastroenteropancreatic neuroendocrine and gastrointestinal stromal tumors in the stomach: A case report

Zhou,Yu; Chen,Ping; Zhong,Liang

doi:10.3892/ol.2015.3666

Compound gastroenteropancreatic neuroendocrine and gastrointestinal stromal tumors in the stomach: A case report

Authors:
- Yu Zhou
- Ping Chen
- Liang Zhong
View Affiliations

Affiliations: Department of Gastrointestinal Surgery, Clinical Medical College of Yangzhou University, Subei People's Hospital of Jiangsu, Yangzhou, Jiangsu 225001, P.R. China
Published online on: September 2, 2015 https://doi.org/10.3892/ol.2015.3666
Pages: 2996-2998

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )

Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )

Cited By (CrossRef): 0 citations Loading Articles...

Abstract

Gastroenteropancreatic neuroendocrine tumors (GEP‑NETs) combined with gastrointestinal stromal tumors (GISTs) are rarely observed in the clinic. In the present study, the case of a 56‑year‑old female diagnosed with compound GEP‑NETs and GISTs was reported. The patient initially presented with epigastric discomfort. The pre‑operative diagnosis was of GISTs based on the endoscopic and imaging findings. A subtotal gastrectomy and Roux‑en‑Y reconstruction were successfully performed. The final diagnosis was revised to be compound GEP‑NETs and GISTs based on the pathological findings. After 17 months of follow‑up examinations using computed tomography and ultrasonography, the patient showed no symptoms or signs of recurrence.

View Figures

View References

1	Jiao Y, Shi C, Edil BH, et al: DAXX/ATRX, MEN1, and mTOR pathway genes are frequently altered in pancreatic neuroendocrine tumors. Science. 331:1199–1203. 2011. View Article : Google Scholar : PubMed/NCBI
2	Modlin IM, Lye KD and Kidd M: A 5-decade analysis of 13,715 carcinoid tumors. Cancer. 97:934–959. 2003. View Article : Google Scholar : PubMed/NCBI
3	Modlin IM, Oberg K, Chung DC, Jensen RT, de Herder WW, Thakker RV, Caplin M, Fave G Delle, Kaltsas GA, Krenning EP, et al: Gastroenteropancreatic neuroendocrine tumours. Lancet Oncol. 9:61–72. 2008. View Article : Google Scholar : PubMed/NCBI
4	Lawrence B, Gustafsson BI, Chan A, Svejda B, Kidd M and Modlin IM: The epidemiology of gastroenteropancreatic neuroendocrine tumors. Endocrinol Metab Clin North Am. 40:1–18. 2011. View Article : Google Scholar : PubMed/NCBI
5	Hirota S, Isozaki K, Moriyama Y, et al: Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors. Science. 279:577–580. 1998. View Article : Google Scholar : PubMed/NCBI
6	Heinrich MC, Corless CL, Duensing A, et al: PDGFRA activating mutations in gastrointestinal stromal tumors. Science. 299:708–710. 2003. View Article : Google Scholar : PubMed/NCBI
7	Hirota S, Ohashi A, Nishida T, et al: Gain-of-function mutations of platelet-derived growth factor receptor alpha gene in gastrointestinal stromal tumors. Gastroenterology. 125:660–667. 2003. View Article : Google Scholar : PubMed/NCBI
8	Daniels M, Lurkin I, Pauli R, et al: Spectrum of KIT/PDGFRA/BRAF mutations and Phosphatidylinositol-3-Kinase pathway gene alterations in gastrointestinal stromal tumors (GIST). Cancer Lett. 312:43–54. 2011. View Article : Google Scholar : PubMed/NCBI
9	Reddy P, Boci K and Charbonneau C: The epidemiologic, health-related quality of life, and economic burden of gastrointestinal stromal tumours. J Clin Pharm Ther. 32:557–565. 2007. View Article : Google Scholar : PubMed/NCBI
10	Miettinen M and Lasota J: Histopathology of gastrointestinal stromal tumor. J Surg Oncol. 104:865–873. 2011. View Article : Google Scholar : PubMed/NCBI
11	Robinson TL, Sircar K, Hewlett BR, Chorneyko K, Riddell RH and Huizinga JD: Gastrointestinal stromal tumors may originate from a subset of CD34-positive interstitial cells of Cajal. Am J Pathol. 156:1157–1163. 2000. View Article : Google Scholar : PubMed/NCBI
12	Ramage JK, Ahmed A, Ardill J, et al: UK and Ireland Neuroendocrine Tumour Society: Guidelines for the management of gastroenteropancreatic neuroendocrine (including carcinoid) tumours (NETs). Gut. 61:6–32. 2012. View Article : Google Scholar : PubMed/NCBI
13	Oberg K: Somatostatin-receptor mediated diagnosis and treatment in gastrointestinal neuroendocrine tumours (GEP-NET's). Rocz Akad Med Bialymst. 50:62–68. 2005.PubMed/NCBI
14	Klöppel G and Anlauf M: Epidemiology, tumour biology and histopathological classification of neuroendocrine tumours of the gastrointestinal tract. Best Pract Res Clin Gastroenterol. 19:507–517. 2005. View Article : Google Scholar : PubMed/NCBI
15	Schimmack S, Svejda B, Lawrence B, Kidd M and Modlin IM: The diversity and commonalities of gastroenteropancreatic neuroendocrine tumors. Langenbecks Arch Surg. 396:273–298. 2011. View Article : Google Scholar : PubMed/NCBI
16	Hamilton SR and Aaltonen LA: World Health Organization Classification of Tumors. Pathology and Genetics of Tumours of the Digestive System. IARC Press. (Lyon). 2000.
17	Modlin IM, Moss SF, Oberg K, Padbury R, Hicks RJ, Gustafsson BI, Wright NA and Kidd M: Gastrointestinal neuroendocrine (carcinoid) tumours: Current diagnosis and management. Med J Aust. 193:46–52. 2010.PubMed/NCBI
18	Klöppel GI, Couvelard A, Perren A, et al: Mallorca Consensus Conference participants; European Neuroendocrine Tumor Society: ENETS Consensus Guidelines for the Standards of Care in Neuroendocrine Tumors: Towards a standardized approach to the diagnosis of gastroenteropancreatic neuroendocrine tumors and their prognostic stratification. Neuroendocrinology. 90:162–166. 2009. View Article : Google Scholar : PubMed/NCBI
19	Oberg K and Castellano D: Current knowledge on diagnosis and staging of neuroendocrine tumors. Cancer Metastasis Rev. 30(Suppl 1): 3–7. 2011. View Article : Google Scholar : PubMed/NCBI
20	George S and Desai J: Management of gastrointestinal stromal tumors in the era of tyrosine kinase inhibitors. Curr Treat Options Oncol. 3:489–496. 2002. View Article : Google Scholar : PubMed/NCBI
21	Rabin I, Chikman B, Lavy R, Sandbank J, Maklakovsky M, Gold-Deutch R, Halpren Z, Wassermann I and Halevy A: Gastrointestinal stromal tumors: A 19 year experience. Isr Med Assoc J. 11:98–102. 2009.PubMed/NCBI
22	Corless CL, Fletcher JA and Heinrich MC: Biology of gastrointestinal stromal tumors. J Clin Oncol. 22:3813–3825. 2004. View Article : Google Scholar : PubMed/NCBI
23	Kang YN, Jung HR and Hwang I: Clinicopathological and immunohistochemical features of gastointestinal stromal tumors. Cancer Res Treat. 42:135–143. 2010. View Article : Google Scholar : PubMed/NCBI
24	National Comprehensive Cancer Network (NCCN): NCCN Clinical Practice Guidelines in Oncology. Soft Tissue Sarcoma. v.2.2009 [Internet]. National Comprehensive Cancer Network (Fort Washington, PA). 2009.