Open Access

Overexpression of forkhead box M1 and urokinase‑type plasminogen activator in gastric cancer is associated with cancer progression and poor prognosis

  • Authors:
    • Jie Ma
    • Guangwei Qi
    • Ji Xu
    • Haibing Ni
    • Wulin Xu
    • Guoqing Ru
    • Zhongsheng Zhao
    • Wenjuan Xu
    • Xujun He
  • View Affiliations

  • Published online on: October 4, 2017     https://doi.org/10.3892/ol.2017.7136
  • Pages: 7288-7296
  • Copyright: © Ma et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Forkhead box M1 (FOXM1) and urokinase‑type plasminogen activator (uPA) are overexpressed and associated with the pathogenesis of multiple types of human malignancy. The aims of the present study were to investigate FOXM1 and uPA expression levels in human gastric cancer using tissue microarray techniques; determining their association with clinicopathological characteristics as well as their prognostic value. Tissue microarray blocks, comprising 436 gastric cancer cases and 92 non‑cancerous adjacent normal gastric tissues, were analyzed for FOXM1 and uPA protein expression levels using immunohistochemistry. The results were analyzed statistically in association with various clinicopathological characteristics and overall survival rates. FOXM1 and uPA were detected in 78.67 (343/436) and 83.26% (363/436) of cancer samples, respectively. FOXM1 and uPA were not expressed in the 92 normal gastric tissue samples. In gastric cancer, FOXM1 and uPA levels were associated with tumor size, depth of invasion, tumor‑node‑metastasis (TNM) stage, lymph node metastasis, vessel invasion and distant metastases. The overall survival rate was significantly decreased in patients expressing FOXM1 and uPA compared with FOXM1‑ and uPA‑negative patients. Cox's multivariate analysis revealed that age, depth of invasion and expression levels of FOXM1 and uPA are independent predictors of survival in patients with gastric cancer. These results indicated that increased FOXM1 and uPA expression levels are associated with the invasive and metastatic processes in human gastric cancer, and inversely associated with patient prognosis. Therefore, FOXM1 and uPA may serve as novel prognostic markers independent of, but supplementing, the TNM staging system.
View Figures
View References

Related Articles

Journal Cover

December-2017
Volume 14 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Ma J, Qi G, Xu J, Ni H, Xu W, Ru G, Zhao Z, Xu W and He X: Overexpression of forkhead box M1 and urokinase‑type plasminogen activator in gastric cancer is associated with cancer progression and poor prognosis. Oncol Lett 14: 7288-7296, 2017.
APA
Ma, J., Qi, G., Xu, J., Ni, H., Xu, W., Ru, G. ... He, X. (2017). Overexpression of forkhead box M1 and urokinase‑type plasminogen activator in gastric cancer is associated with cancer progression and poor prognosis. Oncology Letters, 14, 7288-7296. https://doi.org/10.3892/ol.2017.7136
MLA
Ma, J., Qi, G., Xu, J., Ni, H., Xu, W., Ru, G., Zhao, Z., Xu, W., He, X."Overexpression of forkhead box M1 and urokinase‑type plasminogen activator in gastric cancer is associated with cancer progression and poor prognosis". Oncology Letters 14.6 (2017): 7288-7296.
Chicago
Ma, J., Qi, G., Xu, J., Ni, H., Xu, W., Ru, G., Zhao, Z., Xu, W., He, X."Overexpression of forkhead box M1 and urokinase‑type plasminogen activator in gastric cancer is associated with cancer progression and poor prognosis". Oncology Letters 14, no. 6 (2017): 7288-7296. https://doi.org/10.3892/ol.2017.7136