CT and MR imaging features in phosphaturic mesenchymal tumor-mixed connective tissue: A case report
- Authors:
- Zhenshan Shi
- Yiqiong Deng
- Xiumei Li
- Yueming Li
- Dairong Cao
- Vikash Sahadeo Coossa
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Affiliations: Department of Radiology, First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian 350005, P.R. China, Department of Radiology, Fuzhou Children's Hospital, Fuzhou, Fujian 350005, P.R. China, Fujian Medical University, Fuzhou, Fujian 350005, P.R. China - Published online on: February 5, 2018 https://doi.org/10.3892/ol.2018.7945
- Pages: 4970-4978
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Copyright: © Shi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
This article is mentioned in:
Abstract
Shiba E, Matsuyama A, Shibuya R, Yabuki K, Harada H, Nakamoto M, Kasai T and Hisaoka M: Immunohistochemical and molecular detection of the expression of FGF23 in phosphaturic mesenchymal tumors including the non-phosphaturic variant. Diagn Pathol. 11:262016. View Article : Google Scholar : PubMed/NCBI | |
Nakamura K, Ohishi M, Matsunobu T, Nakashima Y, Sakamoto A, Maekawa A, Oda Y and Iwamoto Y: Tumor-induced osteomalacia caused by a massive phosphaturic mesenchymal tumor of the acetabulum: A case report. Mod Rheumatol. 4:1–5. 2016.(Epub ahead of print). View Article : Google Scholar | |
Hautmann AH, Schroeder J, Wild P, Hautmann MG, Huber E, Hoffstetter P, Fleck M and Girlich C: Tumor-induced osteomalacia: Increased level of FGF-23 in a patient with a phosphaturic mesenchymal tumor at the tibia expressing periostin. Case Rep Endocrino. 2014:7293872014. | |
Norden AG, Laing RJ, Rowe P, Unwin RJ, Wrong O and Crisp AJ: Oncogenic osteomalacia, raised FGF-23 and renal Fanconi syndrome. QJM. 107:139–141. 2014. View Article : Google Scholar : PubMed/NCBI | |
Larsson T, Zahradnik R, Lavigne J, Ljunggren O, Jüppner H and Jonsson KB: Immunohistochemical detection of FGF-23 protein in tumors that cause oncogenic osteomalacia. Eur J Endocrinol. 148:269–276. 2003. View Article : Google Scholar : PubMed/NCBI | |
Dupond JL, Magy N, Mahammedi M, Prie D, Gil H, Meaux-Ruault N and Kantelip B: Oncogenic osteomalacia: The role of the phosphatonins. Diagnostic usefulness of the Fibroblast growth factor 23 measurement in one patient. Rev Med Interne. 26:238–241. 2005.(In French). | |
Nelson AE, Bligh RC, Mirams M, Gill A, Au A, Clarkson A, Jüppner H, Ruff S, Stalley P, Scolyer RA, et al: Clinical case seminar: Fibroblast growth factor 23: A new clinical marker for oncogenic osteomalacia. J Clin Endocrinol Metab. 88:4088–4094. 2003. View Article : Google Scholar : PubMed/NCBI | |
Qari H, Hamao-Sakamoto A, Fuselier C, Cheng YS, Kessler H and Wright J: Phosphaturic mesenchymal tumor: 2 New oral cases and review of 53 cases in the head and neck. Head Neck Pathol. 10:192–200. 2016. View Article : Google Scholar : PubMed/NCBI | |
Okamiya T, Takahashi K, Kamada H, Hirato J, Motoi T, Fukumoto S and Chikamatsu K: Oncogenic osteomalacia caused by an occult paranasal sinus tumor. Auris Nasus Larynx. 42:167–169. 2015. View Article : Google Scholar : PubMed/NCBI | |
Ledford CK, Zelenski NA, Cardona DM, Brigman BE and Eward WC: The phosphaturic mesenchymal tumor: Why is definitive diagnosis and curative surgery often delayed? Clin Orthop Relat Res. 471:3618–3625. 2013. View Article : Google Scholar : PubMed/NCBI | |
Chiam P, Tan HC, Bee YM and Chandran M: Oncogenic osteomalacia-hypophosphataemic spectrum from ‘benignancy’ to ‘malignancy’. Bone. 53:182–187. 2013. View Article : Google Scholar : PubMed/NCBI | |
Morimoto T, Takenaka S, Hashimoto N, Araki N, Myoui A and Yoshikawa H: Malignant phosphaturic mesenchymal tumor of the pelvis: A report of two cases. Oncol Lett. 8:67–71. 2014. View Article : Google Scholar : PubMed/NCBI | |
William J, Laskin W, Nayar R and De Frias D: Diagnosis of phosphaturic mesenchymal tumor (mixed connective tissue type) by cytopathology. Diagn Cytopathol. 40 Suppl 2:E109–E113. 2012. View Article : Google Scholar : PubMed/NCBI | |
Guglielmi G, Bisceglia M, Scillitani A and Folpe AL: Oncogenic osteomalacia due to phosphaturic mesenchymal tumor of the craniofacial sinuses. Clin Cases Miner Bone Metab. 8:45–49. 2011.PubMed/NCBI | |
Chong WH, Molinolo AA, Chen CC and Collins MT: Tumor-induced osteomalacia. Endocr Relat Cancer. 18:R53–R77. 2011. View Article : Google Scholar : PubMed/NCBI | |
Kaul M, Silverberg M, Dicarlo EF, Schneider R, Bass AR and Erkan D: Tumor-induced osteomalacia. Clin Rheumatol. 26:1575–1579. 2007. View Article : Google Scholar : PubMed/NCBI | |
Weidner N and Santa Cruz D: Phosphaturic mesenchymal tumors. A polymorphous group causing osteomalacia or rickets. Cancer. 59:1442–1454. 1987. View Article : Google Scholar : PubMed/NCBI | |
Gatti AP, Tonello L, Neto JA, Teixeira UF, Goldoni MB, Fontes PR, Sampaio JA, Lima LM and Waechter FL: Oncogenic hypophosphatemic osteomalacia: From the first signal of disease to the first signal of healthy. Int J Surg Case Rep. 30:130–133. 2017. View Article : Google Scholar : PubMed/NCBI | |
Mok Y, Lee JC, Lum JH and Petersson F: From epistaxis to bone pain-report of two cases illustrating the clinicopathological spectrum of phosphaturic mesenchymal tumour with fibroblast growth factor receptor 1 immunohistochemical and cytogenetic analyses. Histopathology. 68:925–930. 2016. View Article : Google Scholar : PubMed/NCBI | |
Manara M and Sinigaglia L: ‘Slow and steady wins the race’: The importance of perseverance in the management of oncogenic osteomalacia. Endocrine. 57:1–2. 2017. View Article : Google Scholar : PubMed/NCBI | |
Leow MK, Hamijoyo L, Liew H, Thirugnanam U, Cheng MH, Loke KS, Teo MS, Chuah KL and Chng HH: Oncogenic osteomalacia presenting as a crippling illness in a young man. Lancet. 384:12362014. View Article : Google Scholar : PubMed/NCBI | |
Kaniuka-Jakubowska S, Biernat W and Sworczak K: Oncogenic osteomalacia and its symptoms: Hypophosphatemia, bone pain and pathological fractures. Postepy Hig Med Dosw (online). 66:554–567. 2012.(In Polish). View Article : Google Scholar : PubMed/NCBI | |
Chang CV, Conde SJ, Luvizotto RA, Nunes VS, Bonates MC, Felicio AC, Lindsey SC, Moraes FH, Tagliarini JV, Mazeto GM, et al: Oncogenic osteomalacia: Loss of hypophosphatemia might be the key to avoid misdiagnosis. Arq Bras Endocrinol Metabol. 56:570–573. 2012. View Article : Google Scholar : PubMed/NCBI | |
Ogose A, Hotta T, Emura I, Hatano H, Inoue Y, Umezu H and Endo N: Recurrent malignant variant of phosphaturic mesenchymal tumor with oncogenic osteomalacia. Skeletal Radiol. 30:99–103. 2001. View Article : Google Scholar : PubMed/NCBI | |
Pallavi R, Ravella PM, Gupta P and Popescu A: A case of phosphaturic mesenchymal tumor. Am J Ther. 22:e57–e61. 2015. View Article : Google Scholar : PubMed/NCBI | |
Fatani HA, Sunbuli M, Lai SY and Bell D: Phosphaturic mesenchymal tumor: A report of 6 patients treated at a single institution and comparison with reported series. Ann Diagn Pathol. 17:319–321. 2013. View Article : Google Scholar : PubMed/NCBI | |
Suryawanshi P, Agarwal M, Dhake R, Desai S, Rekhi B, Reddy KB and Jambhekar NA: Phosphaturic mesenchymal tumor with chondromyxoid fibroma-like feature: An unusual morphological appearance. Skeletal Radiol. 40:1481–1485. 2011. View Article : Google Scholar : PubMed/NCBI | |
Akhter M, Sugrue PA, Bains R and Khavkin YA: Oncogenic osteomalacia of the cervical spine: A rare case of curative resection and reconstruction. J Neurosurg Spine. 14:453–456. 2011. View Article : Google Scholar : PubMed/NCBI | |
Sidell D, Lai C, Bhuta S, Barnes L and Chhetri DK: Malignant phosphaturic mesenchymal tumor of the larynx. Laryngoscope. 121:1860–1863. 2011. View Article : Google Scholar : PubMed/NCBI | |
Hendry DS and Wissman R: Case 165: Oncogenic osteomalacia. Radiology. 258:320–322. 2011. View Article : Google Scholar : PubMed/NCBI | |
Shelekhova KV, Kazakov DV, Hes O, Treska V and Michal M: Phosphaturic mesenchymal tumor (mixed connective tissue variant): A case report with spectral analysis. Virchows Arch. 448:232–235. 2006. View Article : Google Scholar : PubMed/NCBI | |
Folpe AL, Fanburg-Smith JC, Billings SD, Bisceglia M, Bertoni F, Cho JY, Econs MJ, Inwards CY, Jan de Beur SM, Mentzel T, et al: Most Osteomalacia-associated mesenchymal tumors are a single histopathologic entity: An analysis of 32 cases and a comprehensive review of the literature. Am J Surg Pathol. 28:1–30. 2004. View Article : Google Scholar : PubMed/NCBI | |
Lopresti M, Daolio PA, Rancati JM, Ligabue N, Andreolli A and Panella L: Rehabilitation of a patient receiving a large-resection hip prosthesis because of a phosphaturic mesenchyal tumor. Clin Pract. 5:8142015. View Article : Google Scholar : PubMed/NCBI | |
Angeles-Angeles A, Reza-Albarrán A, Chable-Montero F, Cordova-Ramón JC, Albores-Saavedra J and Martinez-Benitez B: Phosphaturic mesenchymal tumors. Survey of 8 cases from a single mexican medical institution. Ann Diagn Pathol. 19:375–380. 2015. View Article : Google Scholar : PubMed/NCBI | |
Honda R, Kawabata Y, Ito S and Kikuchi F: Phosphaturic mesenchymal tumor, mixed connective tissue type, non-phosphaturic variant: Report of a case and review of 32 cases from the Japanese published work. J Dermatol. 41:845–849. 2014. View Article : Google Scholar : PubMed/NCBI | |
Deep NL, Cain RB, McCullough AE, Hoxworth JM and Lal D: Sinonasal phosphaturic mesenchymal tumor: Case report and systematic review. Allergy Rhinol (Providence). 5:162–167. 2014. View Article : Google Scholar : PubMed/NCBI | |
Papierska L, Ćwikła JB, Misiorowski W, Rabijewski M, Sikora K and Wanyura H: Unusual case of phosphaturic mesenchymal tumor. Pol Arch Med Wewn. 123:255–256. 2013.PubMed/NCBI | |
Gardner KH, Shon W, Folpe AL, Wieland CN, Tebben PJ and Baum CL: Tumor-induced osteomalacia resulting from primary cutaneous phosphaturic mesenchymal tumor: A case and review of the medical literature. J Cutan Pathol. 40:780–784. 2013. View Article : Google Scholar : PubMed/NCBI | |
Graham RP, Hodge JC, Folpe AL, Oliveira AM, Meyer KJ, Jenkins RB, Sim FH and Sukov WR: A cytogenetic analysis of 2 cases of phosphaturic mesenchymal tumor of mixed connective tissue type. Hum Pathol. 43:1334–1338. 2012. View Article : Google Scholar : PubMed/NCBI | |
Bower RS, Daugherty WP, Giannini C and Parney IF: Intracranial phosphaturic mesenchymal tumor, mixed connective tissue variant presenting without oncogenic osteomalacia. Surg Neurol Int. 3:1512012. View Article : Google Scholar : PubMed/NCBI | |
Woo VL, Landesberg R, Imel EA, Singer SR, Folpe AL, Econs MJ, Kim T, Harik LR and Jacobs TP: Phosphaturic mesenchymal tumor, mixed connective tissue variant, of the mandible: Report of a case and review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 108:925–932. 2009. View Article : Google Scholar : PubMed/NCBI | |
Reis-Filho JS, Paiva ME and Lopes JM: Pathologic quiz case. A 36-year-old woman with muscle pain and weakness. Phosphaturic mesenchymal tumor (mixed connective tissue variant)/oncogenic osteomalacia. Arch Pathol Lab Med. 126:1245–1246. 2002.PubMed/NCBI | |
Singh D, Chopra A, Ravina M, Kongara S, Bhatia E, Kumar N, Gupta S, Yadav S, Dabadghao P, Yadav R, et al: Oncogenic osteomalacia: Role of Ga-68 DOTANOC PET/CT scan in identifying the culprit lesion and its management. Br J Radiol. 90:201608112017. View Article : Google Scholar : PubMed/NCBI | |
Basu S and Fargose P: 177Lu-DOTATATE PRRT in recurrent skull-base phosphaturic mesenchymal tumor causing osteomalacia: A potential application of PRRT beyond neuroendocrine tumors. J Nucl Med Technol. 44:248–250. 2016. View Article : Google Scholar : PubMed/NCBI | |
Kaneuchi Y, Hakozaki M, Yamada H, Hasegawa O, Tajino T and Konno S: Missed causative tumors in diagnosing tumor-induced osteomalacia with (18)F-FDG PET/CT: A potential pitfall of standard-field imaging. Hell J Nucl Med. 19:46–48. 2016.PubMed/NCBI | |
Agrawal K, Bhadada S, Mittal BR, Shukla J, Sood A, Bhattacharya A and Bhansali A: Comparison of 18F-FDG and 68Ga DOTATATE PET/CT in localization of tumor causing oncogenic osteomalacia. Clin Nucl Med. 40:e6–e10. 2015. View Article : Google Scholar : PubMed/NCBI | |
Breer S, Brunkhorst T, Beil FT, Peldschus K, Heiland M, Klutmann S, Barvencik F, Zustin J, Gratz KF and Amling M: 68Ga DOTA-TATE PET/CT allows tumor localization in patients with tumor-induced osteomalacia but negative 111 In-octreotide SPECT/CT. Bone. 64:222–227. 2014. View Article : Google Scholar : PubMed/NCBI | |
Jing H, Li F, Zhong D and Zhuang H: 99 m Tc-HYNIC-TOC (99mTc-hydrazinonicotinyl-Tyr3-octreotide) scintigraphy identifying two separate causative tumors in a patient with tumor-induced osteomalacia (TIO). Clin Nucl Med. 38:664–667. 2013. View Article : Google Scholar : PubMed/NCBI | |
Nakanishi K, Sakai M, Tanaka H, Tsuboi H, Hashimoto J, Hashimoto N and Tomiyama N: Whole-body MR imaging in detecting phosphaturic mesenchymal tumor (PMT) in tumor-induced hypophosphatemic osteomalacia. Magn Reson Med Sci. 12:47–52. 2013. View Article : Google Scholar : PubMed/NCBI | |
Andreopoulou P, Dumitrescu CE, Kelly MH, Brillante BA, Cutler Peck CM, Wodajo FM, Chang R and Collins MT: Selective venous catheterization for the localization of phosphaturic mesenchymal tumors. J Bone Miner Res. 26:1295–1302. 2011. View Article : Google Scholar : PubMed/NCBI | |
Hodgson SF, Clarke BL, Tebben PJ, Mullan BP, Cooney WP III and Shives TC: Oncogenic osteomalacia: Localization of underlying peripheral mesenchymal tumors with use of Tc 99 m sestamibi scintigraphy. Endocr Pract. 12:35–42. 2006. View Article : Google Scholar : PubMed/NCBI | |
Kimizuka T, Ozaki Y and Sumi Y: Usefulness of 201Tl and 99mTc MIBI scintigraphy in a case of oncogenic steomalacia. Ann Nucl Med. 18:63–67. 2004. View Article : Google Scholar : PubMed/NCBI | |
Jan de Beur SM, Streeten EA, Civelek AC, McCarthy EF, Uribe L, Marx SJ, Onobrakpeya O, Raisz LG, Watts NB, Sharon M, et al: Localisation of mesenchymal tumours by somatostatin receptor imaging. Lancet. 359:761–763. 2002. View Article : Google Scholar : PubMed/NCBI | |
Reubi JC, Waser B, Laissue JA and Gebbers JO: Somatostatin and vasoactive intestinal peptide receptors in human mesenchymal tumors: In vitro identification. Cancer Res. 56:1922–1931. 1996.PubMed/NCBI | |
Kong X, Liu Y, Li Y, Zhai Y and Wu Dan: Imaging diagnosis of tumor-induced osteomalacia. Chin J Med Imaging. 22:624–629. 2014.(In Chinese). | |
Cowan S, Lozano-Calderon SA, Uppot RN, Sajed D and Huang AJ: Successful CT guided cryoablation of phosphaturic mesenchymal tumor in the soft tissues causing tumor-induced osteomalacia: A case report. Skeletal Radiol. 46:273–277. 2017. View Article : Google Scholar : PubMed/NCBI | |
Fukumoto S, Takeuchi Y, Nagano A and Fujita T: Diagnostic utility of magnetic resonance imaging skeletal survey in a patient with oncogenic osteomalacia. Bone. 25:375–377. 1999. View Article : Google Scholar : PubMed/NCBI | |
Avila NA, Skarulis M, Rubino DM and Doppman JL: Oncogenic osteomalacia: Lesion detection by MR skeletal survey. AJR Am J Roentgenol. 167:343–345. 1996. View Article : Google Scholar : PubMed/NCBI | |
Monappa V, Naik AM, Mathew M, Rao L, Rao SK, Ramachandra L and PadmaPriya J: Phosphaturic mesenchymal tumour of the mandible-the useful criteria for a diagnosis on fine needle aspiration cytology. Cytopathology. 25:54–56. 2014. View Article : Google Scholar : PubMed/NCBI | |
Ulas A, Dede DS, Sendur MA, Akinci MB and Yalcin B: Expectations of response from octreotide therapy in recurrent phosphaturic mesenchymal tumors-do they reflect reality? Asian Pac J Cancer Prev. 15:10997–10998. 2014. View Article : Google Scholar : PubMed/NCBI | |
Dezfulian M and Wohlgenannt O: Revision hip arthroplasty following recurrence of a phosphaturic mesenchymal tumor. J Surg Case Rep. 9(pii): rjt0592013. | |
Allevi F, Rabbiosi D, Mandalà M and Colletti G: Mesenchymal phosphaturic tumour: Early detection of recurrence. BMJ Case Rep. 2014:bcr20132028272014. View Article : Google Scholar : PubMed/NCBI | |
Kimura S, Yanagisawa M, Fujita Y, Sakihara S, Hisaoka M and Kurose A: A case of phosphaturic mesenchymal tumor of the pelvis with vascular invasion. Pathol Int. 65:510–512. 2015. View Article : Google Scholar : PubMed/NCBI | |
Syed MI, Chatzimichalis M, Rössle M and Huber AM: Recurrent phosphaturic mesenchymal tumour of the temporal bone causing deafness and facial nerve palsy. J Laryngol Otol. 126:721–724. 2012. View Article : Google Scholar : PubMed/NCBI | |
Okiror L, Khalil H, Vaiyapuri S and Kalkat M: Complete resection of a large phosphaturic mesenchymal tumour by chest wall resection and reconstruction. Gen Thorac Cardiovasc Surg. 64:355–358. 2016. View Article : Google Scholar : PubMed/NCBI | |
Farmakis SG and Siegel MJ: Phosphaturic mesenchymal tumor of the tibia with oncogenic osteomalacia in a teenager. Pediatr Radiol. 45:1423–1426. 2015. View Article : Google Scholar : PubMed/NCBI | |
Tarasova VD, Trepp-Carrasco AG, Thompson R, Recker RR, Chong WH, Collins MT and Armas LA: Successful treatment of tumor-induced osteomalacia due to an intracranial tumor by fractionated stereotactic radiotherapy. J Clin Endocrinol Metab. 98:4267–4272. 2013. View Article : Google Scholar : PubMed/NCBI | |
Chong WH, Andreopoulou P, Chen CC, Reynolds J, Guthrie L, Kelly M, Gafni RI, Bhattacharyya N, Boyce AM, El-Maouche D, et al: Tumor localization and biochemical response to cure in tumor-induced osteomalacia. J Bone Miner Res. 28:1386–1398. 2013. View Article : Google Scholar : PubMed/NCBI | |
Imanishi Y, Hashimoto J, Ando W, Kobayashi K, Ueda T, Nagata Y, Miyauchi A, Koyano HM, Kaji H, Saito T, et al: Matrix extracellular phosphoglycoprotein is expressed in causative tumors of oncogenic osteomalacia. J Bone Miner Metab. 30:93–99. 2012. View Article : Google Scholar : PubMed/NCBI | |
Jiang Y, Xia WB, Xing XP, Silva BC, Li M, Wang O, Zhang HB, Li F, Jing HL, Zhong DR, et al: Tumor-induced osteomalacia: An important cause of adult-onset hypophosphatemic osteomalacia in China: Report of 39 cases and review of the literature. J Bone Miner Res. 27:1967–1975. 2012. View Article : Google Scholar : PubMed/NCBI |