search button
Open Access

Combined intra-arterial and intravenous chemotherapy for unresectable, advanced gastric cancer has an improved curative effect compared with intravenous chemotherapy only

  • Authors:
    • Jinfeng Wang
    • Huacun Shi
    • Guang Yang
    • Guangjie Han
    • Man Zhao
    • Xiaoling Duan
    • Lili Mi
    • Xin Han
    • Ning Li
    • Jianfei Shi
    • Xiaolei Yin
    • Fei Yin

  • View Affiliations

  • Published online on: February 16, 2018     https://doi.org/10.3892/ol.2018.8068
  • Pages: 5662-5670

  • Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The aim of the present study was to evaluate the efficacy and safety of a combination of intra‑arterial and intravenous chemotherapy in the treatment of unresectable, advanced gastric cancer, and assess which patients are likely to benefit from combined treatment. The clinical data of 128 patients diagnosed with unresectable, advanced gastric cancer at The Fourth Hospital of Hebei Medical University (Shijiazhuang, China) from January 2009 to September 2012 were retrospectively analyzed. The patients were divided into two groups as follows: Those who received regional intra-arterial chemoembolization plus systemic chemotherapy (combined group; n=62) and those who received systemic chemotherapy only (venous group; n=66). The clinical response, overall survival (OS) and toxic effects in the two groups were compared. Univariate and multivariate analyses were performed to identify the primary factors affecting the survival time of patients in the combined group. The overall response rate was significantly increased (35.5%) in the combined group compared with the venous group (19.7%; P=0.045). The median OS was 14 months in the combined group and 13 months in the venous group, and the 1‑year and 2‑year survival rates in the two groups were 45.2 and 9.7%, and 40.9 and 6.1%, respectively. There were significant differences between the survival curves (P=0.044). The median time to progression in the combined group and the venous group was 10 months and 6 months, respectively, and the difference was statistically significant (P=0.003). Multivariate analysis revealed that tumor‑node‑metastasis (TNM)‑stage and the degree of tumor staining were independent factors affecting OS. No differences in adverse reactions between the two groups were observed (P>0.05). The combination of intra‑arterial and intravenous chemotherapy may effectively improve the rate of clinical response, prolong OS and time to symptomatic progression in patients with unresectable, advanced gastric cancer, in particular those with an earlier TNM stage and distinct tumor staining.
View Figures
View References

Related Articles

Journal Cover

April-2018
Volume 15 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

  • Journal Metrics
  • Impact Factor: 2.5
  • Ranked Oncology
    (total number of cites)
  • CiteScore: 5.7
  • CiteScore Rank: Q2: #139/404 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.574
  • SCImago Journal Rank (SJR): 0.644
International Symposium on Molecular Medicine Conference Banner
The Cancer Story
World Congress on Advances in Oncology and International Symposium on Molecular Medicine Conference Banner
World Academy Of Sciences Banner
Heyday Road Banner

0

Copy and paste a formatted citation
x
Spandidos Publications style
Wang J, Shi H, Yang G, Han G, Zhao M, Duan X, Mi L, Han X, Li N, Shi J, Shi J, et al: Combined intra-arterial and intravenous chemotherapy for unresectable, advanced gastric cancer has an improved curative effect compared with intravenous chemotherapy only. Oncol Lett 15: 5662-5670, 2018.
APA
Wang, J., Shi, H., Yang, G., Han, G., Zhao, M., Duan, X. ... Yin, F. (2018). Combined intra-arterial and intravenous chemotherapy for unresectable, advanced gastric cancer has an improved curative effect compared with intravenous chemotherapy only. Oncology Letters, 15, 5662-5670. https://doi.org/10.3892/ol.2018.8068
MLA
Wang, J., Shi, H., Yang, G., Han, G., Zhao, M., Duan, X., Mi, L., Han, X., Li, N., Shi, J., Yin, X., Yin, F."Combined intra-arterial and intravenous chemotherapy for unresectable, advanced gastric cancer has an improved curative effect compared with intravenous chemotherapy only". Oncology Letters 15.4 (2018): 5662-5670.
Chicago
Wang, J., Shi, H., Yang, G., Han, G., Zhao, M., Duan, X., Mi, L., Han, X., Li, N., Shi, J., Yin, X., Yin, F."Combined intra-arterial and intravenous chemotherapy for unresectable, advanced gastric cancer has an improved curative effect compared with intravenous chemotherapy only". Oncology Letters 15, no. 4 (2018): 5662-5670. https://doi.org/10.3892/ol.2018.8068