In vitro effects of arsenic trioxide, interferon α and zidovudine in adult T cell leukemia/lymphoma cells

  • Authors:
    • Miho Hachiman
    • Makoto Yoshimitsu
    • Chibueze Ezinne
    • Ayako Kuroki
    • Tomohiro Kozako
    • Naomichi Arima
  • View Affiliations

  • Published online on: May 22, 2018     https://doi.org/10.3892/ol.2018.8771
  • Pages: 1305-1311
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Abstract

Despite the efficacy of combination chemotherapy with arsenic trioxide (ATO), interferon α (IFN) and zidovudine (AZT) for adult T cell leukemia/lymphoma (ATL), the precise mechanism underlying this combination treatment effect is unknown. In the present study, ATO/IFN/AZT was examined in an ATL leukemic cell line (S1T, non‑Tax expressing), a human T‑lymphotropic virus 1 (HTLV‑1)‑infected cell line (MT2, Tax‑expressing) and primary ATL cells from patients with acute and chronic ATL. IFN/AZT marginally inhibited MT2 cell proliferation, but substantially inhibited S1T cell proliferation. IFN/AZT increased the cleavage of numerous caspases and PARP in S1T cells, and regulated the signal transducer and activator of transcription 1 and nuclear factor‑κB signaling pathway. These effects represent the potential anti‑ATL mechanisms of INF/AZT in vitro. In addition, the combination of ATO and IFN/AZT demonstrated synergistic effects on S1T cells. Therefore, the Tax‑independent mechanism underlying the anti‑ATL effect of ATO must be further elucidated.
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July-2018
Volume 16 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Hachiman M, Yoshimitsu M, Ezinne C, Kuroki A, Kozako T and Arima N: In vitro effects of arsenic trioxide, interferon α and zidovudine in adult T cell leukemia/lymphoma cells. Oncol Lett 16: 1305-1311, 2018.
APA
Hachiman, M., Yoshimitsu, M., Ezinne, C., Kuroki, A., Kozako, T., & Arima, N. (2018). In vitro effects of arsenic trioxide, interferon α and zidovudine in adult T cell leukemia/lymphoma cells. Oncology Letters, 16, 1305-1311. https://doi.org/10.3892/ol.2018.8771
MLA
Hachiman, M., Yoshimitsu, M., Ezinne, C., Kuroki, A., Kozako, T., Arima, N."In vitro effects of arsenic trioxide, interferon α and zidovudine in adult T cell leukemia/lymphoma cells". Oncology Letters 16.1 (2018): 1305-1311.
Chicago
Hachiman, M., Yoshimitsu, M., Ezinne, C., Kuroki, A., Kozako, T., Arima, N."In vitro effects of arsenic trioxide, interferon α and zidovudine in adult T cell leukemia/lymphoma cells". Oncology Letters 16, no. 1 (2018): 1305-1311. https://doi.org/10.3892/ol.2018.8771