Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
February-2019 Volume 17 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
February-2019 Volume 17 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Synchronous endometrioid endometrial and ovarian carcinomas are biologically related: A clinico‑pathological and molecular (next generation sequencing) study of 22 cases

  • Authors:
    • Nikola Hájková
    • Ivana Tichá
    • Jan Hojný
    • Kristýna Němejcová
    • Michaela Bártů
    • Romana Michálková
    • Michal Zikán
    • David Cibula
    • Jan Laco
    • Tomáš Geryk
    • Gábor Méhes
    • Pavel Dundr
  • View Affiliations / Copyright

    Affiliations: Institute of Pathology, First Faculty of Medicine, Charles University and General University Hospital in Prague, 12800 Prague, Czech Republic, Department of Obstetrics and Gynecology, Bulovka Hospital, First Faculty of Medicine, Charles University, 18081 Prague, Czech Republic, Department of Obstetrics and Gynecology, Oncogynecological Centre, First Faculty of Medicine, Charles University and General University Hospital in Prague, 12000 Prague, Czech Republic, The Fingerland Department of Pathology, Charles University Faculty of Medicine and University Hospital Hradec Kralove, 50005 Hradec Kralove, Czech Republic, Department of Pathology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary
    Copyright: © Hájková et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2207-2214
    |
    Published online on: December 20, 2018
       https://doi.org/10.3892/ol.2018.9855
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The criteria for distinction between independent primary tumors and metastasis from one site to the other in synchronous endometrioid endometrial and ovarian carcinoma (SEO) has been a matter of dispute for a long time. In our study we performed a comprehensive clinico‑pathological and molecular analysis of 22 cases of SEO. Based on conventional clinico‑pathological criteria the cases were classified as independent primary tumors (10 cases) and metastasis from one location to the other (12 cases). All tumors were analyzed by NGS with a panel of 73 genes (219 kbp). Clonal origin was confirmed in all cases by at least one shared mutation in PTEN, AKT1, PIK3CA, KRAS, TP53 and ARID1A. Two patients carried germline pathogenic mutation in cancer‑predisposing genes BRCA1 or BARD1. Microsatellite instable phenotype was detected in 5/22 (22.7%) SEO, but in one case only in the endometrial tumor. In conclusion, our results showed that all 22 SEOs were clonally related, irrespectively of their clinico‑pathological features. Even low grade and low stage tumors classified as independent primaries, according to the conventional morphological criteria, have a clonal origin. From the practical point of view, only the conventional morphological criteria should be used for the classification (staging) of these tumors. However, molecular profiling of these tumors may have prognostic and predictive meaning.
View Figures

Figure 1

Figure 2

View References

1 

Zaino R, Whitney C, Brady MF, DeGeest K, Burger RA and Buller RE: Simultaneously detected endometrial and ovarian carcinomas-a prospective clinicopathologic study of 74 cases: A gynecologic oncology group study. Gynecol Oncol. 83:355–362. 2001. View Article : Google Scholar : PubMed/NCBI

2 

Matias-Guiu X and Stewart CJR: Endometriosis-associated ovarian neoplasia. Pathology. 50:190–204. 2018. View Article : Google Scholar : PubMed/NCBI

3 

Ulbright TM and Roth LM: Metastatic and independent cancers of the endometrium and ovary: A clinicopathologic study of 34 cases. Hum Pathol. 16:28–34. 1985. View Article : Google Scholar : PubMed/NCBI

4 

Scully RE, Young RH and Philip B: Clement MD: Tumors of the ovary, maldeveloped gonads, Fallopian tube and broad ligament: Atlas of tumor pahology (AFIP, Atlas of tumor pathology, No. 23). American registry of pathology. (Washington, DC). 1999.

5 

Schultheis AM, Ng CK, De Filippo MR, Piscuoglio S, Macedo GS, Gatius S, Perez Mies B, Soslow RA, Lim RS, Viale A, et al: Massively parallel sequencing-based clonality analysis of synchronous endometrioid endometrial and ovarian carcinomas. J Natl Cancer Inst. 108:djv4272016. View Article : Google Scholar : PubMed/NCBI

6 

Anglesio MS, Wang YK, Maassen M, Horlings HM, Bashashati A, Senz J, Mackenzie R, Grewal DS, Li-Chang H, Karnezis AN, et al: Synchronous endometrial and ovarian carcinomas: Evidence of clonality. J Natl Cancer Inst. 108:djv4282016. View Article : Google Scholar : PubMed/NCBI

7 

Chao A, Wu RC, Jung SM, Lee YS, Chen SJ, Lu YL, Tsai CL, Lin CY, Tang YH, Chen MY, et al: Implication of genomic characterization in synchronous endometrial and ovarian cancers of endometrioid histology. Gynecol Oncol. 143:60–67. 2016. View Article : Google Scholar : PubMed/NCBI

8 

Yang L, Zhang L, Huang Q, Liu C, Qi L, Li L, Qu T, Wang Y, Liu S, Meng B, et al: Combination of scoring criteria and whole exome sequencing analysis of synchronous endometrial and ovarian carcinomas. Int J Gynecol Cancer. 28:704–712. 2018. View Article : Google Scholar : PubMed/NCBI

9 

Kurman RJ, Carcangiu LM, Herrington SC and Young HR: International Agency for Research on Cancer and World Health Organization: WHO classification of tumours of female reproductive organs. International Agency for Research on Cancer (Lyon). 2014.

10 

Baker CL, Vaughn CP and Samowitz WS: A PIK3CA pyrosequencing-based assay that excludes pseudogene interference. J Mol Diagn. 14:56–60. 2012. View Article : Google Scholar : PubMed/NCBI

11 

Matsuo K, Machida H, Frimer M, Marcus JZ, Pejovic T, Roman LD and Wright JD: Prognosis of women with stage I endometrioid endometrial cancer and synchronous stage I endometrioid ovarian cancer. Gynecol Oncol. 147:558–564. 2017. View Article : Google Scholar : PubMed/NCBI

12 

Natee J, Kietpeerakool C, Srisomboon J, Khunamornpong S, Suprasert P, Phongnarisorn C, Cheewakriangkrai C, Charoenkwan K, Siriaree S and Pantusart A: Clinicopathologic analysis of women with synchronous primary carcinomas of the endometrium and ovary: 10- year experience from Chiang Mai University Hospital. Asian Pac J Cancer Prev. 7:234–238. 2006.PubMed/NCBI

13 

Narin MA, Karalok A, Basaran D, Ureyen I, Turkmen O, Turan T and Tulunay G: Does synchronous endometrioid endometrial cancer have any prognostic effect on Stage I endometrioid ovarian cancer? Eur J Obstet Gynecol Reprod Biol. 200:113–116. 2016. View Article : Google Scholar : PubMed/NCBI

14 

Lim YK, Padma R, Foo L, Chia YN, Yam P, Chia J, Khoo-Tan H, Yap SP and Yeo R: Survival outcome of women with synchronous cancers of endometrium and ovary: A 10 year retrospective cohort study. J Gynecol Oncol. 22:239–243. 2011. View Article : Google Scholar : PubMed/NCBI

15 

Dębska-Szmich S, Czernek U, Frąckowiak M, Frackowiak M, Zięba A, Czyzykowski R, Kulejewska D and Potemski P: Synchronous primary ovarian and endometrial cancers: A series of cases and a review of literature. Prz Menopauzalny. 13:64–69. 2014.PubMed/NCBI

16 

Eifel P, Hendrickson M, Ross J, Ballon S, Martinez A and Kempson R: Simultaneous presentation of carcinoma involving the ovary and the uterine corpus. Cancer. 50:163–170. 1982. View Article : Google Scholar : PubMed/NCBI

17 

Karki SC and Chapagain U: Synchronous primary tumors of the endometrium and ovary. J Pathol Nepal. 2:189–192. 2012. View Article : Google Scholar

18 

Liu Y, Li J, Jin H, Lu Y and Lu X: Clinicopathological characteristics of patients with synchronous primary endometrial and ovarian cancers: A review of 43 cases. Oncol Lett. 5:267–270. 2013. View Article : Google Scholar : PubMed/NCBI

19 

Soliman PT, Slomovitz BM, Broaddus RR, Sun CC, Oh JC, Eifel PJ, Gershenson DM and Lu KH: Synchronous primary cancers of the endometrium and ovary: A single institution review of 84 cases. Gynecol Oncol. 94:456–462. 2004. View Article : Google Scholar : PubMed/NCBI

20 

Song T, Seong SJ, Bae DS, Suh DH, Kim DY, Lee KH, Lim MC and Lee TS: Synchronous primary cancers of the endometrium and ovary in young women: A Korean Gynecologic Oncology Group Study. Gynecol Oncol. 131:624–628. 2013. View Article : Google Scholar : PubMed/NCBI

21 

Sozen H, Vatansever D, Iyibozkurt AC, Topuz S, Ozsurmeli M, Salihoglu Y, Guzelbey B and Berkman S: Clinicopathologic and survival analyses of synchronous primary endometrial and epithelial ovarian cancers. J Obstet Gynaecol Res. 41:1813–1819. 2015. View Article : Google Scholar : PubMed/NCBI

22 

Prat J, Matias-Guiu X and Barreto J: Simultaneous carcinoma involving the endometrium and the ovary. A clinicopathologic, immunohistochemical, and DNA flow cytometric study of 18 cases. Cancer. 68:2455–2459. 1991. View Article : Google Scholar : PubMed/NCBI

23 

Halperin R, Zehavi S, Hadas E, Habler L, Bukovsky I and Schneider D: Simultaneous carcinoma of the endometrium and ovary vs endometrial carcinoma with ovarian metastases: A clinical and immunohistochemical determination. Int J Gynecol Cancer. 13:32–37. 2003. View Article : Google Scholar : PubMed/NCBI

24 

Desouki MM, Kallas SJ, Khabele D, Crispens MA, Hameed O and Fadare O: Differential vimentin expression in ovarian and uterine corpus endometrioid adenocarcinomas: Diagnostic utility in distinguishing double primaries from metastatic tumors. Int J Gynecol Pathol. 33:274–281. 2014. View Article : Google Scholar : PubMed/NCBI

25 

Fujii H, Matsumoto T, Yoshida M, Furugen Y, Takagaki T, Iwabuchi K, Nakata Y, Takagi Y, Moriya T, Ohtsuji N, et al: Genetics of synchronous uterine and ovarian endometrioid carcinoma: Combined analyses of loss of heterozygosity, PTEN mutation and microsatellite instability. Hum Pathol. 33:421–428. 2002. View Article : Google Scholar : PubMed/NCBI

26 

Moreno-Bueno G, Gamallo C, Pérez-Gallego L, de Mora JC, Suárez A and Palacios J: Beta-catenin expression pattern, beta-catenin gene mutations, and microsatellite instability in endometrioid ovarian carcinomas and synchronous endometrial carcinomas. Diagn Mol Pathol. 10:116–122. 2001. View Article : Google Scholar : PubMed/NCBI

27 

Kobayashi Y, Nakamura K, Nomura H, Banno K, Irie H, Adachi M, Iida M, Umene K, Nogami Y, Masuda K, et al: Clinicopathologic analysis with immunohistochemistry for DNA mismatch repair protein expression in synchronous primary endometrial and ovarian cancers. Int J Gynecol Cancer. 25:440–446. 2015. View Article : Google Scholar : PubMed/NCBI

28 

Emmert-Buck MR, Chuaqui R, Zhuang Z, Nogales F, Liotta LA and Merino MJ: Molecular analysis of synchronous uterine and ovarian endometrioid tumors. Int J Gynecol Pathol. 16:143–148. 1997. View Article : Google Scholar : PubMed/NCBI

29 

Fujita M, Enomoto T, Wada H, Inoue M, Okudaira Y and Shroyer KR: Application of clonal analysis. Differential diagnosis for synchronous primary ovarian and endometrial cancers and metastatic cancer. Am J Clin Pathol. 105:350–359. 1996. View Article : Google Scholar : PubMed/NCBI

30 

Irving JA, Catasús L, Gallardo A, Bussaglia E, Romero M, Matias-Guiu X and Prat J: Synchronous endometrioid carcinomas of the uterine corpus and ovary: Alterations in the beta-catenin (CTNNB1) pathway are associated with independent primary tumors and favorable prognosis. Hum Pathol. 36:605–619. 2005. View Article : Google Scholar : PubMed/NCBI

31 

Lin WM, Forgacs E, Warshal DP, Yeh IT, Martin JS, Ashfaq R and Muller CY: Loss of heterozygosity and mutational analysis of the PTEN/MMAC1 gene in synchronous endometrial and ovarian carcinomas. Clin Cancer Res. 4:2577–2583. 1998.PubMed/NCBI

32 

Matias-Guiu X, Bussaglia E, Catasus L, Lagarda H, Gras E, Machin P, Prat J; Correspondence re: W.M. Lin, ; et al: loss of heterozygosity and mutational analysis of the PTEN/MMAC1 gene in synchronous endometrial and ovarian carcinomas. Clin. Cancer Res. 4:2577–2583. 1998.Clin Cancer Res 6: 1598-1600, 2000. PubMed/NCBI

33 

Nishimura N, Hachisuga T, Nabeshima K and Kawarabayashi T: Synchronous endometrial and ovarian carcinomas: Analysis of genetic relationship of the tumors. Int J Oncol. 27:1519–1526. 2005.PubMed/NCBI

34 

Ricci R, Komminoth P, Bannwart F, Torhorst J, Wight E, Heitz PU and Caduff RF: PTEN as a molecular marker to distinguish metastatic from primary synchronous endometrioid carcinomas of the ovary and uterus. Diagn Mol Pathol. 12:71–78. 2003. View Article : Google Scholar : PubMed/NCBI

35 

Shenson DL, Gallion HH, Powell DE and Pieretti M: Loss of heterozygosity and genomic instability in synchronous endometrioid tumors of the ovary and endometrium. Cancer. 76:650–657. 1995. View Article : Google Scholar : PubMed/NCBI

36 

Kelemen LE, Rambau PF, Koziak JM, Steed H and Köbel M: Synchronous endometrial and ovarian carcinomas: Predictors of risk and associations with survival and tumor expression profiles. Cancer Causes Control. 28:447–457. 2017. View Article : Google Scholar : PubMed/NCBI

37 

Ratajska M, Antoszewska E, Piskorz A, Brozek I, Borg Å, Kusmierek H, Biernat W and Limon J: Cancer predisposing BARD1 mutations in breast-ovarian cancer families. Breast Cancer Res Treat. 131:89–97. 2012. View Article : Google Scholar : PubMed/NCBI

38 

Hamel N, Feng BJ, Foretova L, Stoppa-Lyonnet D, Narod SA, Imyanitov E, Sinilnikova O, Tihomirova L, Lubinski J, Gronwald J, et al: On the origin and diffusion of BRCA1 c.5266dupC (5382insC) in European populations. Eur J Hum Genet. 19:300–306. 2011. View Article : Google Scholar : PubMed/NCBI

39 

Pohlreich P, Zikan M, Stribrna J, Kleibl Z, Janatova M, Kotlas J, Zidovska J, Novotny J, Petruzelka L, Szabo C and Matous B: High proportion of recurrent germline mutations in the BRCA1 gene in breast and ovarian cancer patients from the Prague area. Breast Cancer Res. 7:R728–R736. 2005. View Article : Google Scholar : PubMed/NCBI

40 

Cancer Genome Atlas Research Network: Comprehensive molecular characterization of gastric adenocarcinoma. Nature. 513:202–209. 2014. View Article : Google Scholar : PubMed/NCBI

41 

Cerami E, Gao JJ, Dogrusoz U, Gross BE, Sumer SO, Aksoy BA, Jacobsen A, Byrne CJ, Heuer ML, Larsson E, et al: The cBio cancer genomics portal: An open platform for exploring multidimensional cancer genomics data. Cancer Discov. 2:401–404. 2012. View Article : Google Scholar : PubMed/NCBI

42 

Němejcová K, Tichá I, Kleiblová P, Bártů M, Cibula D, Jirsová K and Dundr P: Expression, epigenetic and genetic changes of HNF1B in endometrial lesions. Pathol Oncol Res. 22:523–530. 2016. View Article : Google Scholar : PubMed/NCBI

43 

Wu RC, Veras E, Lin J, Gerry E, Bahadirli-Talbott A, Baras A, Ayhan A, Shih IM and Wang TL: Elucidating the pathogenesis of synchronous and metachronous tumors in a woman with endometrioid carcinomas using a whole-exome sequencing approach. Cold Spring Harb Mol Case Stud. 3(pii): a0016932017. View Article : Google Scholar : PubMed/NCBI

44 

Valtcheva N, Lang FM, Noske A, Samartzis EP, Schmidt AM, Bellini E, Fink D, Moch H, Rechsteiner M, Dedes KJ and Wild PJ: Tracking the origin of simultaneous endometrial and ovarian cancer by next-generation sequencing-a case report. BMC Cancer. 17:662017. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Hájková N, Tichá I, Hojný J, Němejcová K, Bártů M, Michálková R, Zikán M, Cibula D, Laco J, Geryk T, Geryk T, et al: Synchronous endometrioid endometrial and ovarian carcinomas are biologically related: A clinico‑pathological and molecular (next generation sequencing) study of 22 cases. Oncol Lett 17: 2207-2214, 2019.
APA
Hájková, N., Tichá, I., Hojný, J., Němejcová, K., Bártů, M., Michálková, R. ... Dundr, P. (2019). Synchronous endometrioid endometrial and ovarian carcinomas are biologically related: A clinico‑pathological and molecular (next generation sequencing) study of 22 cases. Oncology Letters, 17, 2207-2214. https://doi.org/10.3892/ol.2018.9855
MLA
Hájková, N., Tichá, I., Hojný, J., Němejcová, K., Bártů, M., Michálková, R., Zikán, M., Cibula, D., Laco, J., Geryk, T., Méhes, G., Dundr, P."Synchronous endometrioid endometrial and ovarian carcinomas are biologically related: A clinico‑pathological and molecular (next generation sequencing) study of 22 cases". Oncology Letters 17.2 (2019): 2207-2214.
Chicago
Hájková, N., Tichá, I., Hojný, J., Němejcová, K., Bártů, M., Michálková, R., Zikán, M., Cibula, D., Laco, J., Geryk, T., Méhes, G., Dundr, P."Synchronous endometrioid endometrial and ovarian carcinomas are biologically related: A clinico‑pathological and molecular (next generation sequencing) study of 22 cases". Oncology Letters 17, no. 2 (2019): 2207-2214. https://doi.org/10.3892/ol.2018.9855
Copy and paste a formatted citation
x
Spandidos Publications style
Hájková N, Tichá I, Hojný J, Němejcová K, Bártů M, Michálková R, Zikán M, Cibula D, Laco J, Geryk T, Geryk T, et al: Synchronous endometrioid endometrial and ovarian carcinomas are biologically related: A clinico‑pathological and molecular (next generation sequencing) study of 22 cases. Oncol Lett 17: 2207-2214, 2019.
APA
Hájková, N., Tichá, I., Hojný, J., Němejcová, K., Bártů, M., Michálková, R. ... Dundr, P. (2019). Synchronous endometrioid endometrial and ovarian carcinomas are biologically related: A clinico‑pathological and molecular (next generation sequencing) study of 22 cases. Oncology Letters, 17, 2207-2214. https://doi.org/10.3892/ol.2018.9855
MLA
Hájková, N., Tichá, I., Hojný, J., Němejcová, K., Bártů, M., Michálková, R., Zikán, M., Cibula, D., Laco, J., Geryk, T., Méhes, G., Dundr, P."Synchronous endometrioid endometrial and ovarian carcinomas are biologically related: A clinico‑pathological and molecular (next generation sequencing) study of 22 cases". Oncology Letters 17.2 (2019): 2207-2214.
Chicago
Hájková, N., Tichá, I., Hojný, J., Němejcová, K., Bártů, M., Michálková, R., Zikán, M., Cibula, D., Laco, J., Geryk, T., Méhes, G., Dundr, P."Synchronous endometrioid endometrial and ovarian carcinomas are biologically related: A clinico‑pathological and molecular (next generation sequencing) study of 22 cases". Oncology Letters 17, no. 2 (2019): 2207-2214. https://doi.org/10.3892/ol.2018.9855
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team