Open Access

Expression of FOXM1 and PLK1 predicts prognosis of patients with hepatocellular carcinoma

  • Authors:
    • Weiqiang Fan
    • Huan Ma
    • Bin Jin
  • View Affiliations

  • Published online on: March 15, 2022     https://doi.org/10.3892/ol.2022.13266
  • Article Number: 146
  • Copyright: © Fan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Hepatocellular carcinoma (HCC) is one of the most frequently encountered malignant tumor types and to improve its treatment, effective prognostic biomarkers are urgently required. Cell cycle dysregulation is a significant feature of cancer progression. The aim of the present study was to estimate the expression levels of forkhead box protein M1 (FOXM1) and polo‑like kinase 1 (PLK1), both of which have essential roles in cell cycle regulation, and determine their prognostic value in HCC. To this end, FOXM1 and PLK1 expression levels were assessed in The Cancer Genome Atlas and International Cancer Genome Consortium Japan HCC cohorts, and the associations between their co‑expression were determined via Pearson's correlation analysis. Furthermore, the overall survival and disease‑free survival in these cohorts for different FOXM1 and PLK1 expression statuses were analyzed. In vitro knockdown experiments were also performed using Huh7 cells. The results obtained indicated overexpression of FOXM1 and PLK1 in HCC tumor tissues as well as a positive correlation between FOXM1 and PLK1 expression. The results also suggested that both FOXM1 and PLK1 are required for HCC cell proliferation. In addition, upregulation of FOXM1 and PLK1 was indicated to be associated with poor prognosis of patients with HCC. However, only their coordinated overexpression was identified as an independent prognostic factor for HCC.
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May-2022
Volume 23 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Fan W, Ma H and Jin B: Expression of FOXM1 and PLK1 predicts prognosis of patients with hepatocellular carcinoma. Oncol Lett 23: 146, 2022
APA
Fan, W., Ma, H., & Jin, B. (2022). Expression of FOXM1 and PLK1 predicts prognosis of patients with hepatocellular carcinoma. Oncology Letters, 23, 146. https://doi.org/10.3892/ol.2022.13266
MLA
Fan, W., Ma, H., Jin, B."Expression of FOXM1 and PLK1 predicts prognosis of patients with hepatocellular carcinoma". Oncology Letters 23.5 (2022): 146.
Chicago
Fan, W., Ma, H., Jin, B."Expression of FOXM1 and PLK1 predicts prognosis of patients with hepatocellular carcinoma". Oncology Letters 23, no. 5 (2022): 146. https://doi.org/10.3892/ol.2022.13266