<sup>18</sup>F‑fluorodeoxyglucose positron emission tomography predicts recurrence and histological grade of extrahepatic bile duct cancer

Yachi,Takafumi; Yoshizawa,Tadashi; Kimura,Norihisa; Seino,Hiroko; Morohashi,Satoko; Goto,Shintaro; Ishido,Keinosuke; Kijima,Hiroshi; Hakamada,Kenichi

doi:10.3892/ol.2023.13711

¹⁸F‑fluorodeoxyglucose positron emission tomography predicts recurrence and histological grade of extrahepatic bile duct cancer

Authors:
- Takafumi Yachi
- Tadashi Yoshizawa
- Norihisa Kimura
- Hiroko Seino
- Satoko Morohashi
- Shintaro Goto
- Keinosuke Ishido
- Hiroshi Kijima
- Kenichi Hakamada
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Affiliations: Department of Gastroenterological Surgery, Hirosaki University Graduate School of Medicine, Hirosaki, Aomori 036‑8562, Japan, Department of Pathology and Bioscience, Hirosaki University Graduate School of Medicine, Hirosaki, Aomori 036‑8562, Japan, Department of Radiology, Aomori National Hospital, Namioka, Aomori 038‑1331, Japan, Department of Pathology and Bioscience, Hirosaki University Graduate School of Medicine, Hirosaki, Aomori 036‑8562, Japan
Published online on: February 9, 2023 https://doi.org/10.3892/ol.2023.13711
Article Number: 125
Copyright: © Yachi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Malignant tumors in cholangiocarcinoma are diagnosed and staged using ¹⁸F‑fluorodeoxyglucose positron emission tomography (FDG‑PET) and clinical analysis. However, comprehensive analysis, including pathological analysis, has not yet been sufficiently performed. In the present study, the maximum standardized uptake value (SUVmax) was calculated using FDG‑PET and its relationship with clinicopathological factors was analyzed. The present study included 86 patients who underwent preoperative FDG‑PET/computed tomography (CT) and did not receive chemotherapy among 331 patients with hilar and distal cholangiocarcinoma. Receiver operating characteristic analysis with recurrence events was used to determine the SUVmax cutoff of 4.9. Immunohistochemical staining of glucose transporter 1 (Glut1), hypoxia‑inducible factor‑1α and Ki‑67 was performed for pathological analysis. The standardized uptake value (SUV)‑high group (SUVmax ≥4.9) had a higher postoperative recurrence rate (P<0.046) and higher Glut1 and Ki‑67 expression rates (P<0.05 and P<0.0001, respectively). Furthermore, SUVmax and Glut1 expression (r=0.298; P<0.01) and SUVmax and Ki‑67 expression rates (r=0.527; P<0.0001) were positively correlated. The preoperative measurement of SUVmax by PET‑CT is useful in predicting recurrence as well as cancer malignancy.

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