Open Access

Roles of USP9X in cellular functions and tumorigenesis (Review)

  • Authors:
    • Yimei Meng
    • Chaojin Hong
    • Sifu Yang
    • Zhiquan Qin
    • Liu Yang
    • Yumei Huang
  • View Affiliations

  • Published online on: October 10, 2023     https://doi.org/10.3892/ol.2023.14093
  • Article Number: 506
  • Copyright: © Meng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Ubiquitin‑specific peptidase 9X (USP9X) is involved in certain human diseases, including malignancies, atherosclerosis and certain diseases of the nervous system. USP9X promotes the deubiquitination and stabilization of diverse substrates, thereby exerting a versatile range of effects on pathological and physiological processes. USP9X serves vital roles in the processes of cell survival, invasion and migration in various types of cancer. The present review aims to highlight the current knowledge of USP9X in terms of its structure and the possible mediatory mechanisms involved in certain types of cancer, providing a thorough introduction to its biological functions in carcinogenesis and further outlining its oncogenic or suppressive properties in a diverse range of cancer types. Finally, several perspectives regarding USP9X‑targeted pharmacological therapeutics in cancer development are discussed.
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December-2023
Volume 26 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Meng Y, Hong C, Yang S, Qin Z, Yang L and Huang Y: Roles of USP9X in cellular functions and tumorigenesis (Review). Oncol Lett 26: 506, 2023
APA
Meng, Y., Hong, C., Yang, S., Qin, Z., Yang, L., & Huang, Y. (2023). Roles of USP9X in cellular functions and tumorigenesis (Review). Oncology Letters, 26, 506. https://doi.org/10.3892/ol.2023.14093
MLA
Meng, Y., Hong, C., Yang, S., Qin, Z., Yang, L., Huang, Y."Roles of USP9X in cellular functions and tumorigenesis (Review)". Oncology Letters 26.6 (2023): 506.
Chicago
Meng, Y., Hong, C., Yang, S., Qin, Z., Yang, L., Huang, Y."Roles of USP9X in cellular functions and tumorigenesis (Review)". Oncology Letters 26, no. 6 (2023): 506. https://doi.org/10.3892/ol.2023.14093