Open Access

Rectal ulcer associated with lenvatinib 15 years after definitive radiotherapy for prostate cancer: A case report

  • Authors:
    • Yujiro Kawata
    • Kenta Watanabe
    • Ryoji Tokiya
    • Yoshiyuki Miyaji
    • Akiko Shiotani
    • Kuniaki Katsui
  • View Affiliations

  • Published online on: November 8, 2023     https://doi.org/10.3892/ol.2023.14139
  • Article Number: 6
  • Copyright: © Kawata et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Lenvatinib is a multi‑kinase inhibitor that blocks vascular endothelial growth factor, fibroblast growth factor and platelet‑derived growth factor receptors. The present study describes a case of rectal ulceration triggered by lenvatinib treatment for hepatocellular carcinoma 15 years after definitive radiotherapy for prostate cancer. A 58‑year‑old man underwent definitive external beam radiotherapy and high‑dose‑rate brachytherapy for prostate cancer. A total of 15 years after radiotherapy for prostate cancer, the patient was diagnosed with hepatocellular carcinoma with multiple metastases. Treatment with 12 mg/day lenvatinib was commenced. A total of 4 months after starting lenvatinib therapy, the patient experienced persistent anal pain with a deep ulceration of the anterior wall of the lower rectum. As the pain did not improve, the patient chose to undergo a colostomy, resulting in the resolution of the anorectal pain. To the best of our knowledge, the present case report is the first to report on lenvatinib‑induced rectal ulcers after radiotherapy.
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January-2024
Volume 27 Issue 1

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Spandidos Publications style
Kawata Y, Watanabe K, Tokiya R, Miyaji Y, Shiotani A and Katsui K: Rectal ulcer associated with lenvatinib 15 years after definitive radiotherapy for prostate cancer: A case report. Oncol Lett 27: 6, 2024
APA
Kawata, Y., Watanabe, K., Tokiya, R., Miyaji, Y., Shiotani, A., & Katsui, K. (2024). Rectal ulcer associated with lenvatinib 15 years after definitive radiotherapy for prostate cancer: A case report. Oncology Letters, 27, 6. https://doi.org/10.3892/ol.2023.14139
MLA
Kawata, Y., Watanabe, K., Tokiya, R., Miyaji, Y., Shiotani, A., Katsui, K."Rectal ulcer associated with lenvatinib 15 years after definitive radiotherapy for prostate cancer: A case report". Oncology Letters 27.1 (2024): 6.
Chicago
Kawata, Y., Watanabe, K., Tokiya, R., Miyaji, Y., Shiotani, A., Katsui, K."Rectal ulcer associated with lenvatinib 15 years after definitive radiotherapy for prostate cancer: A case report". Oncology Letters 27, no. 1 (2024): 6. https://doi.org/10.3892/ol.2023.14139