Open Access

Dietary and supplementary vitamin C intake and the risk of lung cancer: A meta‑analysis of cohort studies

  • Authors:
    • Dung V. Tran
    • Xuan Quy Luu
    • Huong T.T. Tran
    • Seung-Kwon Myung
  • View Affiliations

  • Published online on: November 10, 2023     https://doi.org/10.3892/ol.2023.14144
  • Article Number: 10
  • Copyright: © Tran et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Previous cohort studies reported inconsistent findings regarding the association between dietary or supplementary vitamin C intake and lung cancer risk. These associations were investigated by conducting a meta‑analysis of cohort studies. The PubMed and EMBASE databases were utilized, using keywords related to the topic from inception to April 15, 2022. Pooled effect sizes, such as relative risk (RR) or hazard ratio (HR) with 95% confidence intervals (CIs), were calculated using a random‑effects model. A total of 20 cohort studies from 13 articles were included in the final analysis. In a meta‑analysis of all studies, there was no significant association between dietary or supplementary vitamin C intake and lung cancer risk (RR/HR, 0.90; 95% CI, 0.80‑1.01; I2=56.4%; n=20). In the subgroup meta‑analysis by the source of vitamin C, dietary vitamin C intake decreased the risk of lung cancer (RR/HR, 0.82; 95% CI, 0.73‑0.92; I2=42.5%; n=14), whereas there was no association between supplementary vitamin C intake and lung cancer risk (RR/HR, 1.01; 95% CI, 0.84‑1.22; n=4). The present meta‑analysis of cohort studies found that dietary vitamin C intake is beneficial for preventing lung cancer, whereas its supplementary intake does not have a beneficial effect.
View Figures
View References

Related Articles

Journal Cover

January-2024
Volume 27 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Tran DV, Luu XQ, Tran HT and Myung S: Dietary and supplementary vitamin C intake and the risk of lung cancer: A meta‑analysis of cohort studies. Oncol Lett 27: 10, 2024
APA
Tran, D.V., Luu, X.Q., Tran, H.T., & Myung, S. (2024). Dietary and supplementary vitamin C intake and the risk of lung cancer: A meta‑analysis of cohort studies. Oncology Letters, 27, 10. https://doi.org/10.3892/ol.2023.14144
MLA
Tran, D. V., Luu, X. Q., Tran, H. T., Myung, S."Dietary and supplementary vitamin C intake and the risk of lung cancer: A meta‑analysis of cohort studies". Oncology Letters 27.1 (2024): 10.
Chicago
Tran, D. V., Luu, X. Q., Tran, H. T., Myung, S."Dietary and supplementary vitamin C intake and the risk of lung cancer: A meta‑analysis of cohort studies". Oncology Letters 27, no. 1 (2024): 10. https://doi.org/10.3892/ol.2023.14144