Open Access

Current status and perspectives of genetic testing in gastrointestinal cancer (Review)

  • Authors:
    • Tasuku Matsuoka
    • Masakazu Yashiro
  • View Affiliations

  • Published online on: November 16, 2023     https://doi.org/10.3892/ol.2023.14155
  • Article Number: 21
  • Copyright: © Matsuoka et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Genetic testing has become widespread in daily medical care for gastrointestinal (GI) cancers. However, unlike breast cancer and non‑small cell lung cancer, in which personalized medicine targeting various driver genes is standardized, the incidence of targeted gene abnormalities in GI cancers is low. Nevertheless, such abnormalities may be linked to therapeutic agents and the further development of therapeutic agents for personalized medicine for GI cancers is desired. A liquid biopsy is of great benefit in offering clinical decision support, in applications such as GI cancer screening, surgical interventions, monitoring disease status and enhancing patient survival outcomes, all of which would contribute to personalized medicine. Germline genetic testing is required for several types of GI cancer, which shows clinical indications of hereditary predisposition. The increasing use of multigene panel testing has redefined gene‑cancer associations, and consequently the estimate of cancer risk that vary from low to high penetrance. Comprehensive genetic testing can enable the detection of novel treatment targets and the discovery of undefined multiple diagnostic/predictive markers, which may enhance the molecular‑level understanding of GI cancers. Genetic testing can also aid the design of more appropriate and adequate genomic‑driven therapies for patients who may benefit from other standardized therapeutic methods.
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January-2024
Volume 27 Issue 1

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Spandidos Publications style
Matsuoka T and Matsuoka T: Current status and perspectives of genetic testing in gastrointestinal cancer (Review). Oncol Lett 27: 21, 2024
APA
Matsuoka, T., & Matsuoka, T. (2024). Current status and perspectives of genetic testing in gastrointestinal cancer (Review). Oncology Letters, 27, 21. https://doi.org/10.3892/ol.2023.14155
MLA
Matsuoka, T., Yashiro, M."Current status and perspectives of genetic testing in gastrointestinal cancer (Review)". Oncology Letters 27.1 (2024): 21.
Chicago
Matsuoka, T., Yashiro, M."Current status and perspectives of genetic testing in gastrointestinal cancer (Review)". Oncology Letters 27, no. 1 (2024): 21. https://doi.org/10.3892/ol.2023.14155