A rare presentation of primary cardiac diffuse large B‑cell lymphoma: A case report
- Authors:
- Hongyan Jiang
- Haijun Liu
- Linwei Zhao
- Ling Yang
- Yunfei Zhao
View Affiliations
Affiliations: Department of Pathology, Suining Central Hospital, Suining, Sichuan 629000, P.R. China, Department of Ultrasound, Suining Central Hospital, Suining, Sichuan 629000, P.R. China, Department of Radiology and Imaging, Suining Central Hospital, Suining, Sichuan 629000, P.R. China
- Published online on: December 4, 2023 https://doi.org/10.3892/ol.2023.14174
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Article Number:
40
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Copyright: © Jiang
et al. This is an open access article distributed under the
terms of Creative
Commons Attribution License.
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Abstract
Primary cardiac lymphomas display a low frequency, sudden onset, swift progression of illness and elevated mortality rates. The current study presents a unique instance of primary cardiac diffuse large B‑cell lymphoma and examines its clinical manifestations, pathological characteristics and differential diagnosis. A 64‑year‑old male patient sought medical attention due to cardiac debility and exertional dyspnea persisting for >10 days. Chest enhanced computed tomography revealed a moderately enhancing irregular mass in the ventricular area, exhibiting limited demarcation from the pericardium and left atrium, accompanied by irregular thickening of the interventricular septum. The postoperative specimen showed the presence of yellow fish‑like tumor tissue. Immunohistochemical analysis revealed the presence of lymphocytes positive for CD20, BCL‑2, BCL‑6, c‑Myc‑binding protein, mutated melanoma‑associated antigen 1 and CD79a, along with a high Ki‑67 proliferation index of 80%. Conversely, CD10, CD30, CD3, pan cytokeratin, cyclin D1, desmin and vimentin marker results were found to be negative. Additionally, in situ hybridization demonstrated a lack of Epstein‑Barr virus‑encoded small RNA expression. The present case report emphasizes the significance of conducting a thorough analysis of the clinical manifestations of diffuse large B‑cell lymphoma to assist clinicians in establishing a diagnosis and determining an effective treatment approach, thereby enhancing the patient's prognosis.
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