Major impact of prognosis by age and sex in patients with primary mediastinal large B‑cell lymphoma

  • Authors:
    • Hsuan-Jen Shih
    • Ming-Chung Kuo
    • Tung-Liang Lin
    • Hsiao-Wen Kao
    • Jin-Hou Wu
    • Yu-Shin Hung
    • Che-Wei Ou
    • Yi-Jiun Su
    • Hung Chang
  • View Affiliations

  • Published online on: December 13, 2023     https://doi.org/10.3892/ol.2023.14190
  • Article Number: 57
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Abstract

The effective prognostic factors for primary mediastinal large B‑cell lymphoma (PMLBCL) vary among published studies. The aim of the present study was to explore the factors influencing the overall survival (OS) and progression‑free survival (PFS) of patients with PMLBCL at a single institute in Taiwan. This retrospective study was conducted to analyze the prognostic impact of age, sex, disease stage, International Prognostic Index (IPI) score, treatment modality and initial response. A total of 72 patients with a median age of 28 years were included in the study. The mean OS and PFS were 171.40 and 159.77 months, respectively. Female sex, age ≤60 years, receiving radiotherapy (RT) and achieving a complete response were found to be associated with a significantly improved OS and PFS. In addition, high‑intensity chemotherapy and an IPI score ≤1 were associated with longer OS, and early‑stage disease was associated with a PFS superior to that of advanced‑stage disease. The predictive value of IPI is limited in PMLBCL. Therefore, it is necessary to develop a novel prognostic system. The present study revealed the impact of sex on prognosis and, therefore, this factor should be considered in future prognostic evaluations. Since a complete post‑treatment response was found to be important, high‑intensity chemotherapy is recommended. However, low‑intensity treatment followed by RT consolidation appears to be a feasible approach in elderly patients.
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February-2024
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Spandidos Publications style
Shih H, Kuo M, Lin T, Kao H, Wu J, Hung Y, Ou C, Su Y and Chang H: Major impact of prognosis by age and sex in patients with primary mediastinal large B‑cell lymphoma. Oncol Lett 27: 57, 2024
APA
Shih, H., Kuo, M., Lin, T., Kao, H., Wu, J., Hung, Y. ... Chang, H. (2024). Major impact of prognosis by age and sex in patients with primary mediastinal large B‑cell lymphoma. Oncology Letters, 27, 57. https://doi.org/10.3892/ol.2023.14190
MLA
Shih, H., Kuo, M., Lin, T., Kao, H., Wu, J., Hung, Y., Ou, C., Su, Y., Chang, H."Major impact of prognosis by age and sex in patients with primary mediastinal large B‑cell lymphoma". Oncology Letters 27.2 (2024): 57.
Chicago
Shih, H., Kuo, M., Lin, T., Kao, H., Wu, J., Hung, Y., Ou, C., Su, Y., Chang, H."Major impact of prognosis by age and sex in patients with primary mediastinal large B‑cell lymphoma". Oncology Letters 27, no. 2 (2024): 57. https://doi.org/10.3892/ol.2023.14190