Multidisciplinary treatment of advanced cervical esophageal adenocarcinoma derived from a gastric inlet patch: A case report

Okamoto,Koichi; Yamaguchi,Takahisa; Asakawa,Tetsuya; Kaida,Daisuke; Miyata,Takashi; Hayashi,Tomoyuki; Ojima,Toshihiko; Fujita,Hideto; Inaki,Noriyuki; Kinami,Shinichi; Ninomiya,Itasu; Takamura,Hiroyuki

doi:10.3892/ol.2024.14253

Multidisciplinary treatment of advanced cervical esophageal adenocarcinoma derived from a gastric inlet patch: A case report

Authors:
- Koichi Okamoto
- Takahisa Yamaguchi
- Tetsuya Asakawa
- Daisuke Kaida
- Takashi Miyata
- Tomoyuki Hayashi
- Toshihiko Ojima
- Hideto Fujita
- Noriyuki Inaki
- Shinichi Kinami
- Itasu Ninomiya
- Hiroyuki Takamura
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Affiliations: Department of General and Digestive Surgery, Kanazawa Medical University Hospital, Kahoku, Ishikawa 920‑0293, Japan, Department of Gastroenterological Surgery, Ishikawa Prefectural Central Hospital, Kanazawa, Ishikawa 920‑8530, Japan, Department of Surgery, Houju Memorial Hospital, Nomi, Ishikawa 923‑1226, Japan, Department of Gastroenterology, Kanazawa University, Kanazawa, Ishikawa 920‑8641, Japan, Department of Surgery, Toyama Nishi General Hospital, Toyama, Toyama 939‑2716, Japan, Department of Gastrointestinal Surgery, Kanazawa University, Kanazawa, Ishikawa 920‑8641, Japan, Department of Surgery, Fukui Prefectural Hospital, Fukui, Fukui 910‑0846, Japan
Published online on: January 25, 2024 https://doi.org/10.3892/ol.2024.14253
Article Number: 120
Copyright: © Okamoto et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

A gastric inlet patch (GIP) is an ectopic gastric mucosal lesion usually arising at the cervical esophagus that may rarely cause esophageal adenocarcinoma (EAC). To the best of our knowledge, this is the first case of a GIP‑derived EAC that was successfully treated using a multidisciplinary treatment approach. A 64‑year‑old man was referred to the Department of Gastrointestinal Surgery, Kanazawa University Hospital (Kanazawa, Japan) for surgical treatment of refractory recurrent cervical EAC derived from GIP who had previously been treated with induction chemotherapy, definitive chemoradiotherapy and photodynamic therapy (PDT). Esophagogastroduodenoscopy revealed a stenotic tumor at the GIP site in the cervical esophagus and submucosal tumors with suspected multiple intramural metastases in the anal side of the thoracic esophagus. The patient underwent robot‑assisted thoracoscopic esophagectomy with laryngopharyngectomy and cervical lymphadenectomy as radical salvage surgery 4 months after the last PDT procedure. After postoperative adjuvant chemotherapy using oral administration of tegafur/gimeracil/oteracil (oral 5‑fluorouracil prodrug) for 1 year; at present, the patient is alive without recurrence 3 years after the operation.

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