Open Access

Applications of single‑cell omics and spatial transcriptomics technologies in gastric cancer (Review)

  • Authors:
    • Liping Ren
    • Danni Huang
    • Hongjiang Liu
    • Lin Ning
    • Peiling Cai
    • Xiaolong Yu
    • Yang Zhang
    • Nanchao Luo
    • Hao Lin
    • Jinsong Su
    • Yinghui Zhang
  • View Affiliations

  • Published online on: February 14, 2024     https://doi.org/10.3892/ol.2024.14285
  • Article Number: 152
  • Copyright: © Ren et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Gastric cancer (GC) is a prominent contributor to global cancer‑related mortalities, and a deeper understanding of its molecular characteristics and tumor heterogeneity is required. Single‑cell omics and spatial transcriptomics (ST) technologies have revolutionized cancer research by enabling the exploration of cellular heterogeneity and molecular landscapes at the single‑cell level. In the present review, an overview of the advancements in single‑cell omics and ST technologies and their applications in GC research is provided. Firstly, multiple single‑cell omics and ST methods are discussed, highlighting their ability to offer unique insights into gene expression, genetic alterations, epigenomic modifications, protein expression patterns and cellular location in tissues. Furthermore, a summary is provided of key findings from previous research on single‑cell omics and ST methods used in GC, which have provided valuable insights into genetic alterations, tumor diagnosis and prognosis, tumor microenvironment analysis, and treatment response. In summary, the application of single‑cell omics and ST technologies has revealed the levels of cellular heterogeneity and the molecular characteristics of GC, and holds promise for improving diagnostics, personalized treatments and patient outcomes in GC.
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April-2024
Volume 27 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Ren L, Huang D, Liu H, Ning L, Cai P, Yu X, Zhang Y, Luo N, Lin H, Su J, Su J, et al: Applications of single‑cell omics and spatial transcriptomics technologies in gastric cancer (Review). Oncol Lett 27: 152, 2024
APA
Ren, L., Huang, D., Liu, H., Ning, L., Cai, P., Yu, X. ... Zhang, Y. (2024). Applications of single‑cell omics and spatial transcriptomics technologies in gastric cancer (Review). Oncology Letters, 27, 152. https://doi.org/10.3892/ol.2024.14285
MLA
Ren, L., Huang, D., Liu, H., Ning, L., Cai, P., Yu, X., Zhang, Y., Luo, N., Lin, H., Su, J., Zhang, Y."Applications of single‑cell omics and spatial transcriptomics technologies in gastric cancer (Review)". Oncology Letters 27.4 (2024): 152.
Chicago
Ren, L., Huang, D., Liu, H., Ning, L., Cai, P., Yu, X., Zhang, Y., Luo, N., Lin, H., Su, J., Zhang, Y."Applications of single‑cell omics and spatial transcriptomics technologies in gastric cancer (Review)". Oncology Letters 27, no. 4 (2024): 152. https://doi.org/10.3892/ol.2024.14285