High expression of microRNA-200c predicts poor clinical outcome in diffuse large B-cell lymphoma

  • Authors:
    • Mattias Berglund
    • Gustav Hedström
    • Rose-Marie Amini
    • Gunilla Enblad
    • Ulf Thunberg
  • View Affiliations

  • Published online on: December 10, 2012     https://doi.org/10.3892/or.2012.2173
  • Pages: 720-724
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Abstract

Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous group of B-cell lymphomas. A new and important tool for understanding the biology and clinical course of DLBCL is microRNA expression. This study presents microRNA-200c expression data from 61 DLBCL patients treated with CHOP or R-CHOP. Patients with high microRNA-200c expression had a median survival of 20.3 months and a significantly shorter overall survival (P=0.019) compared to patients with low microRNA-200c expression, who had a median survival of 35.8 months. We also found that patients treated with R-CHOP only and displaying high microRNA-200c expression had a significantly shorter overall survival compared to patients with low microRNA-200c expression, where all patients were still alive at the time of the last follow-up (P=0.0036). Lastly, we found that patients with high microRNA-200c expression had a significantly shorter time from initial diagnosis to the first relapse compared to patients with low microRNA-200c expression (P=0.0001). To our knowledge, this is the first study showing that the expression of microRNA-200c affects the clinical outcome of DLBCL patients, and that microRNA-200c is involved in the biology of DLBCL development, although larger studies are necessary to confirm this. Further investigations may also help to elucidate the biological role of microRNA-200c in DLBCL.
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February 2013
Volume 29 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Berglund M, Hedström G, Amini R, Enblad G and Thunberg U: High expression of microRNA-200c predicts poor clinical outcome in diffuse large B-cell lymphoma. Oncol Rep 29: 720-724, 2013
APA
Berglund, M., Hedström, G., Amini, R., Enblad, G., & Thunberg, U. (2013). High expression of microRNA-200c predicts poor clinical outcome in diffuse large B-cell lymphoma. Oncology Reports, 29, 720-724. https://doi.org/10.3892/or.2012.2173
MLA
Berglund, M., Hedström, G., Amini, R., Enblad, G., Thunberg, U."High expression of microRNA-200c predicts poor clinical outcome in diffuse large B-cell lymphoma". Oncology Reports 29.2 (2013): 720-724.
Chicago
Berglund, M., Hedström, G., Amini, R., Enblad, G., Thunberg, U."High expression of microRNA-200c predicts poor clinical outcome in diffuse large B-cell lymphoma". Oncology Reports 29, no. 2 (2013): 720-724. https://doi.org/10.3892/or.2012.2173