Cyclooxygenase-2 is induced by p38 MAPK and promotes cell survival

  • Authors:
    • Rosanna Parente
    • Elisabetta Trifirò
    • Francesca Cuozzo
    • Sandro Valia
    • Mara Cirone
    • Livia Di Renzo
  • View Affiliations

  • Published online on: February 27, 2013     https://doi.org/10.3892/or.2013.2308
  • Pages: 1999-2004
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Abstract

The Na+ ionophore monensin affects cellular pH and, depending on its concentration, causes the survival or death of tumor cells. In the present study, we elucidated the survival pathway activated in U937 cells, a human lymphoma-derived cell line. These cells treated with monensin at a concentration of 5 µM were growth-arrested in G1, activated p38 mitogen-activated protein kinase (MAPK) and showed an increased expression of cyclooxygenase-2 (COX-2). The latter two molecular events were linked, as pharmacological inhibition of the MAPK did not allow COX-2 increased expression. Furthermore, we showed that p38 and COX-2 keep monensin-stressed U937 cells alive, as pharmacological inhibition of each enzyme caused cell death.
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May 2013
Volume 29 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Parente R, Trifirò E, Cuozzo F, Valia S, Cirone M and Di Renzo L: Cyclooxygenase-2 is induced by p38 MAPK and promotes cell survival. Oncol Rep 29: 1999-2004, 2013
APA
Parente, R., Trifirò, E., Cuozzo, F., Valia, S., Cirone, M., & Di Renzo, L. (2013). Cyclooxygenase-2 is induced by p38 MAPK and promotes cell survival. Oncology Reports, 29, 1999-2004. https://doi.org/10.3892/or.2013.2308
MLA
Parente, R., Trifirò, E., Cuozzo, F., Valia, S., Cirone, M., Di Renzo, L."Cyclooxygenase-2 is induced by p38 MAPK and promotes cell survival". Oncology Reports 29.5 (2013): 1999-2004.
Chicago
Parente, R., Trifirò, E., Cuozzo, F., Valia, S., Cirone, M., Di Renzo, L."Cyclooxygenase-2 is induced by p38 MAPK and promotes cell survival". Oncology Reports 29, no. 5 (2013): 1999-2004. https://doi.org/10.3892/or.2013.2308