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Article

18F-FDG uptake on PET is a predictive marker of thymidylate synthase expression in patients with thoracic neoplasms

  • Authors:
    • Kyoichi Kaira
    • Nobuyuki Yamamoto
    • Masahiro Endo
    • Hirotsugu Kenmotsu
    • Tateaki Naito
    • Akira Ono
    • Haruyasu Murakami
    • Yasuhisa Ohde
    • Takashi Nakajima
    • Toshiaki Takahashi
  • View Affiliations / Copyright

    Affiliations: Division of Thoracic Oncology, Shizuoka Cancer Center, Shizuoka 411-8777, Japan, Division of Diagnostic Radiology, Shizuoka Cancer Center, Shizuoka 411-8777, Japan, Division of Thoracic Surgery, Shizuoka Cancer Center, Shizuoka 411-8777, Japan, Division of Pathology, Shizuoka Cancer Center, Shizuoka 411-8777, Japan
  • Pages: 209-215
    |
    Published online on: October 24, 2013
       https://doi.org/10.3892/or.2013.2816
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Abstract

The aim of this study was to investigate the relationship between the expression levels of thymidylate synthase (TS) and 2-[18F]-fluoro-2-deoxy-D-glucose (18F-FDG) uptake on positron emission tomography (PET) in various thoracic neoplasms. In total, 392 patients [non-small cell lung cancer (NSCLC) (n=140), malignant pleural mesothelioma (MPM) (n=21), pulmonary metastatic tumors (PMT) (n=148), thymic epithelial tumors (n=49) and pulmonary neuroendocrine (NE) tumor (n=34)] who underwent 18F-FDG PET before treatment were included in this study. Tumor sections were stained using immunohistochemistry for determination of TS, orotate phosphoribosyltransferase (OPRT), dihydropyrimidine dehydrogenase (DPD), vascular endothelial growth factor (VEGF), microvessel density (MVD), CD34 and p53. The expression of TS in thoracic neoplasms had a positivity of 58% (230/392), and the positive rates of TS expression in NSCLC, PMT, thymic epithelial tumor, NE tumor and MPM samples were 56, 57, 57, 85 and 47%, respectively. The positivity of TS expression was significantly higher in NE tumors compared to that in other thoracic tumors. A statistically significant correlation between TS expression and 18F-FDG uptake was observed in thoracic neoplasms, in particular primary lung adenocarcinomas, high-grade NE tumors, thymomas and MPMs. Moreover, TS expression was closely associated with angiogenesis, DPD, OPRT and p53. Our results indicated that SUVmax by 18F-FDG uptake may be an alternative biomarker for predicting TS expression in patients with primary lung adenocarcinoma, high-grade NE tumor, thymoma and MPM.
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Copy and paste a formatted citation
Spandidos Publications style
Kaira K, Yamamoto N, Endo M, Kenmotsu H, Naito T, Ono A, Murakami H, Ohde Y, Nakajima T, Takahashi T, Takahashi T, et al: 18F-FDG uptake on PET is a predictive marker of thymidylate synthase expression in patients with thoracic neoplasms. Oncol Rep 31: 209-215, 2014.
APA
Kaira, K., Yamamoto, N., Endo, M., Kenmotsu, H., Naito, T., Ono, A. ... Takahashi, T. (2014). 18F-FDG uptake on PET is a predictive marker of thymidylate synthase expression in patients with thoracic neoplasms. Oncology Reports, 31, 209-215. https://doi.org/10.3892/or.2013.2816
MLA
Kaira, K., Yamamoto, N., Endo, M., Kenmotsu, H., Naito, T., Ono, A., Murakami, H., Ohde, Y., Nakajima, T., Takahashi, T."18F-FDG uptake on PET is a predictive marker of thymidylate synthase expression in patients with thoracic neoplasms". Oncology Reports 31.1 (2014): 209-215.
Chicago
Kaira, K., Yamamoto, N., Endo, M., Kenmotsu, H., Naito, T., Ono, A., Murakami, H., Ohde, Y., Nakajima, T., Takahashi, T."18F-FDG uptake on PET is a predictive marker of thymidylate synthase expression in patients with thoracic neoplasms". Oncology Reports 31, no. 1 (2014): 209-215. https://doi.org/10.3892/or.2013.2816
Copy and paste a formatted citation
x
Spandidos Publications style
Kaira K, Yamamoto N, Endo M, Kenmotsu H, Naito T, Ono A, Murakami H, Ohde Y, Nakajima T, Takahashi T, Takahashi T, et al: 18F-FDG uptake on PET is a predictive marker of thymidylate synthase expression in patients with thoracic neoplasms. Oncol Rep 31: 209-215, 2014.
APA
Kaira, K., Yamamoto, N., Endo, M., Kenmotsu, H., Naito, T., Ono, A. ... Takahashi, T. (2014). 18F-FDG uptake on PET is a predictive marker of thymidylate synthase expression in patients with thoracic neoplasms. Oncology Reports, 31, 209-215. https://doi.org/10.3892/or.2013.2816
MLA
Kaira, K., Yamamoto, N., Endo, M., Kenmotsu, H., Naito, T., Ono, A., Murakami, H., Ohde, Y., Nakajima, T., Takahashi, T."18F-FDG uptake on PET is a predictive marker of thymidylate synthase expression in patients with thoracic neoplasms". Oncology Reports 31.1 (2014): 209-215.
Chicago
Kaira, K., Yamamoto, N., Endo, M., Kenmotsu, H., Naito, T., Ono, A., Murakami, H., Ohde, Y., Nakajima, T., Takahashi, T."18F-FDG uptake on PET is a predictive marker of thymidylate synthase expression in patients with thoracic neoplasms". Oncology Reports 31, no. 1 (2014): 209-215. https://doi.org/10.3892/or.2013.2816
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