Open Access

The role of ferroptosis in radiotherapy and combination therapy for head and neck squamous cell carcinoma (Review)

  • Authors:
    • Yu Feng
    • Xiulei Li
    • Bingwu Yang
    • Maocai Li
    • Yongya Du
    • Jing Wang
    • Siyu Liu
    • Lili Gong
    • Lianqing Li
    • Lei Gao
  • View Affiliations

  • Published online on: April 18, 2024     https://doi.org/10.3892/or.2024.8738
  • Article Number: 79
  • Copyright: © Feng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Head and neck squamous cell carcinoma (HNSCC) is a highly aggressive, heterogeneous tumour usually caused by alcohol and tobacco consumption, making it one of the most common malignancies worldwide. Despite the fact that various therapeutic approaches such as surgery, radiation therapy (RT), chemotherapy (CT) and targeted therapy have been widely used for HNSCC in recent years, its recurrence rate and mortality rate remain high. RT is the standard treatment choice for HNSCC, which induces reactive oxygen species production and causes oxidative stress, ultimately leading to tumour cell death. CT is a widely recognized form of cancer treatment that treats a variety of cancers by eliminating cancer cells and preventing them from reproducing. Immune checkpoint inhibitor and epidermal growth factor receptor are important in the treatment of recurrent or metastatic HNSCC. Iron death, a type of cell death regulated by peroxidative damage to phospholipids containing polyunsaturated fatty acids in cell membranes, has been found to be a relevant death response triggered by tumour RT in recent years. In the present review, an overview of the current knowledge on RT and combination therapy and iron death in HNSCC was provided, the mechanisms by which RT induces iron death in tumour cells were summarized, and therapeutic strategies to target iron death in HNSCC were explored. The current review provided important information for future studies of iron death in the treatment of HNSCC.
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June-2024
Volume 51 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Feng Y, Li X, Yang B, Li M, Du Y, Wang J, Liu S, Gong L, Li L, Gao L, Gao L, et al: The role of ferroptosis in radiotherapy and combination therapy for head and neck squamous cell carcinoma (Review). Oncol Rep 51: 79, 2024
APA
Feng, Y., Li, X., Yang, B., Li, M., Du, Y., Wang, J. ... Gao, L. (2024). The role of ferroptosis in radiotherapy and combination therapy for head and neck squamous cell carcinoma (Review). Oncology Reports, 51, 79. https://doi.org/10.3892/or.2024.8738
MLA
Feng, Y., Li, X., Yang, B., Li, M., Du, Y., Wang, J., Liu, S., Gong, L., Li, L., Gao, L."The role of ferroptosis in radiotherapy and combination therapy for head and neck squamous cell carcinoma (Review)". Oncology Reports 51.6 (2024): 79.
Chicago
Feng, Y., Li, X., Yang, B., Li, M., Du, Y., Wang, J., Liu, S., Gong, L., Li, L., Gao, L."The role of ferroptosis in radiotherapy and combination therapy for head and neck squamous cell carcinoma (Review)". Oncology Reports 51, no. 6 (2024): 79. https://doi.org/10.3892/or.2024.8738