Experimental study of the effects on apoptosis of docetaxel alone and in combination with irradiation.
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- Published online on: March 1, 2000 https://doi.org/10.3892/or.7.2.289
- Pages: 289-382
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Abstract
The effects of docetaxel alone and in combination with irradiation were experimentally investigated in terms of induction of apoptosis. A human ependymoblastoma was transplanted into nude mice, and they were intravenously injected with docetaxel, followed or preceded by irradiation with a single dose of 2 Gy. Apoptosis was less common in the docetaxel-alone group than in the irradiation-alone group. When administration of docetaxel was followed by irradiation, apoptosis was equal to or less common than in the irradiation-alone group. Apoptosis was most common in the irradiation-followed-by-docetaxel group. The incidence of mitosis was lower in the irradiation-alone group and the irradiation-followed-by-docetaxel group than in the docetaxel-alone group and the docetaxel-followed-by-irradiation group. The combined effect of irradiation and docetaxel appears to be useful in inducing apoptosis, but the sequence of irradiation and docetaxel is important.