Mitogen-activated protein kinase phosphatase-1: A critical phosphatase manipulating mitogen-activated protein kinase signaling in cardiovascular disease (Review)
- Authors:
- Chang-Yi Li
- Ling-Chao Yang
- Kai Guo
- Yue-Peng Wang
- Yi-Gang Li
-
Affiliations: Department of Cardiology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200092, P.R. China - Published online on: February 18, 2015 https://doi.org/10.3892/ijmm.2015.2104
- Pages: 1095-1102
This article is mentioned in:
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|
Garrington TP and Johnson GL: Organization and regulation of mitogen-activated protein kinase signaling pathways. Curr Opin Cell Biol. 11:211–218. 1999. View Article : Google Scholar : PubMed/NCBI | |
|
Su B and Karin M: Mitogen-activated protein kinase cascades and regulation of gene expression. Curr Opin Immunol. 8:402–411. 1996. View Article : Google Scholar : PubMed/NCBI | |
|
Rincon M and Davis RJ: Regulation of the immune response by stress-activated protein kinases. Immunol Rev. 228:212–224. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Owens DM and Keyse SM: Differential regulation of MAP kinase signalling by dual-specificity protein phosphatases. Oncogene. 26:3203–3213. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Rohini A, Agrawal N, Koyani CN and Singh R: Molecular targets and regulators of cardiac hypertrophy. Pharmacol Res. 61:269–280. 2010. View Article : Google Scholar | |
|
Alonso A, Sasin J, Bottini N, et al: Protein tyrosine phosphatases in the human genome. Cell. 117:699–711. 2004. View Article : Google Scholar : PubMed/NCBI | |
|
Chang L and Karin M: Mammalian MAP kinase signalling cascades. Nature. 410:37–40. 2001. View Article : Google Scholar : PubMed/NCBI | |
|
Muslin AJ: MAPK signalling in cardiovascular health and disease: molecular mechanisms and therapeutic targets. Clin Sci (Lond). 115:203–218. 2008. View Article : Google Scholar | |
|
Keyse SM: Dual-specificity MAP kinase phosphatases (MKPs) and cancer. Cancer Metastasis Rev. 27:253–261. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Doddareddy MR, Rawling T and Ammit AJ: Targeting mitogen-activated protein kinase phosphatase-1 (MKP-1): structure-based design of MKP-1 inhibitors and upregulators. Curr Med Chem. 19:163–173. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Wu JJ, Zhang L and Bennett AM: The noncatalytic amino terminus of mitogen-activated protein kinase phosphatase 1 directs nuclear targeting and serum response element transcriptional regulation. Mol Cell Biol. 25:4792–4803. 2005. View Article : Google Scholar : PubMed/NCBI | |
|
Sun H, Charles CH, Lau LF and Tonks NK: MKP-1 (3CH134), an immediate early gene product, is a dual specificity phosphatase that dephosphorylates MAP kinase in vivo. Cell. 75:487–493. 1993. View Article : Google Scholar : PubMed/NCBI | |
|
Franklin CC and Kraft AS: Conditional expression of the mitogen-activated protein kinase (MAPK) phosphatase MKP-1 preferentially inhibits p38 MAPK and stress-activated protein kinase in U937 cells. J Biol Chem. 272:16917–16923. 1997. View Article : Google Scholar : PubMed/NCBI | |
|
Liu Y, Gorospe M, Yang C and Holbrook NJ: Role of mitogen-activated protein kinase phosphatase during the cellular response to genotoxic stress. Inhibition of c-Jun N-terminal kinase activity and AP-1-dependent gene activation. J Biol Chem. 270:8377–8380. 1995. View Article : Google Scholar : PubMed/NCBI | |
|
Raingeaud J, Gupta S, Rogers JS, et al: Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine. J Biol Chem. 270:7420–7426. 1995. View Article : Google Scholar : PubMed/NCBI | |
|
Hammer M, Mages J, Dietrich H, et al: Dual specificity phosphatase 1 (DUSP1) regulates a subset of LPS-induced genes and protects mice from lethal endotoxin shock. J Exp Med. 203:15–20. 2006. View Article : Google Scholar | |
|
Chu Y, Solski PA, Khosravi-Far R, Der CJ and Kelly K: The mitogen-activated protein kinase phosphatases PAC1, MKP-1, and MKP-2 have unique substrate specificities and reduced activity in vivo toward the ERK2 sevenmaker mutation. J Biol Chem. 271:6497–6501. 1996. View Article : Google Scholar : PubMed/NCBI | |
|
Wang X, Zhao Q, Matta R, et al: Inducible nitric-oxide synthase expression is regulated by mitogen-activated protein kinase phosphatase-1. J Biol Chem. 284:27123–27134. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Keyse SM: Protein phosphatases and the regulation of mitogen-activated protein kinase signalling. Curr Opin Cell Biol. 12:186–192. 2000. View Article : Google Scholar : PubMed/NCBI | |
|
Brondello JM, Brunet A, Pouyssegur J and McKenzie FR: The dual specificity mitogen-activated protein kinase phosphatase-1 and -2 are induced by the p42/p44MAPK cascade. J Biol Chem. 272:1368–1376. 1997. View Article : Google Scholar : PubMed/NCBI | |
|
Cho IJ, Woo NR and Kim SG: The identification of C/EBPbeta as a transcription factor necessary for the induction of MAPK phosphatase-1 by toll-like receptor-4 ligand. Arch Biochem Biophys. 479:88–96. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Lim HW, New L, Han J and Molkentin JD: Calcineurin enhances MAPK phosphatase-1 expression and p38 MAPK inactivation in cardiac myocytes. J Biol Chem. 276:15913–15919. 2001. View Article : Google Scholar : PubMed/NCBI | |
|
Valledor AF, Xaus J, Marques L and Celada A: Macrophage colony-stimulating factor induces the expression of mitogen-activated protein kinase phosphatase-1 through a protein kinase C-dependent pathway. J Immunol. 163:2452–2462. 1999.PubMed/NCBI | |
|
Kuwano Y, Kim HH, Abdelmohsen K, et al: MKP-1 mRNA stabilization and translational control by RNA-binding proteins HuR and NF90. Mol Cell Biol. 28:4562–4575. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Emmons J, Townley-Tilson WH, Deleault KM, et al: Identification of TTP mRNA targets in human dendritic cells reveals TTP as a critical regulator of dendritic cell maturation. RNA. 14:888–902. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Brondello JM, Pouyssegur J and McKenzie FR: Reduced MAP kinase phosphatase-1 degradation after p42/p44MAPK-dependent phosphorylation. Science. 286:2514–2517. 1999. View Article : Google Scholar | |
|
Lin YW and Yang JL: Cooperation of ERK and SCFSkp2 for MKP-1 destruction provides a positive feedback regulation of proliferating signaling. J Biol Chem. 281:915–926. 2006. View Article : Google Scholar | |
|
Slack DN, Seternes OM, Gabrielsen M and Keyse SM: Distinct binding determinants for ERK2/p38alpha and JNK map kinases mediate catalytic activation and substrate selectivity of map kinase phosphatase-1. J Biol Chem. 276:16491–16500. 2001. View Article : Google Scholar : PubMed/NCBI | |
|
Cao W, Bao C, Padalko E and Lowenstein CJ: Acetylation of mitogen-activated protein kinase phosphatase-1 inhibits Toll-like receptor signaling. J Exp Med. 205:1491–1503. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Kamata H, Honda S, Maeda S, Chang L, Hirata H and Karin M: Reactive oxygen species promote TNFalpha-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases. Cell. 120:649–661. 2005. View Article : Google Scholar : PubMed/NCBI | |
|
Boutros T, Chevet E and Metrakos P: Mitogen-activated protein (MAP) kinase/MAP kinase phosphatase regulation: roles in cell growth, death, and cancer. Pharmacol Rev. 60:261–310. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Navis AC, van den Eijnden M, Schepens JT, Hooft van Huijsduijnen R, Wesseling P and Hendriks WJ: Protein tyrosine phosphatases in glioma biology. Acta Neuropathol. 119:157–175. 2010. View Article : Google Scholar : | |
|
Wang X and Liu Y: Regulation of innate immune response by MAP kinase phosphatase-1. Cell Signal. 19:1372–1382. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Weber C and Noels H: Atherosclerosis: current pathogenesis and therapeutic options. Nat Med. 17:1410–1422. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Libby P: Inflammation in atherosclerosis. Nature. 420:868–874. 2002. View Article : Google Scholar : PubMed/NCBI | |
|
Zakkar M, Chaudhury H, Sandvik G, et al: Increased endothelial mitogen-activated protein kinase phosphatase-1 expression suppresses proinflammatory activation at sites that are resistant to atherosclerosis. Circ Res. 103:726–732. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Zakkar M, Van der Heiden K, Luong le A, et al: Activation of Nrf2 in endothelial cells protects arteries from exhibiting a proinflammatory state. Arterioscler Thromb Vasc Biol. 29:1851–1857. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Kim HS, Ullevig SL, Zamora D, Lee CF and Asmis R: Redox regulation of MAPK phosphatase 1 controls monocyte migration and macrophage recruitment. Proc Natl Acad Sci USA. 109:E2803–E2812. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Chaudhury H, Zakkar M, Boyle J, et al: c-Jun N-terminal kinase primes endothelial cells at atheroprone sites for apoptosis. Arterioscler Thromb Vasc Biol. 30:546–553. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Salojin KV, Owusu IB, Millerchip KA, Potter M, Platt KA and Oravecz T: Essential role of MAPK phosphatase-1 in the negative control of innate immune responses. J Immunol. 176:1899–1907. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Chi H, Barry SP, Roth RJ, et al: Dynamic regulation of pro- and anti-inflammatory cytokines by MAPK phosphatase 1 (MKP-1) in innate immune responses. Proc Natl Acad Sci USA. 103:2274–2279. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Reddy ST, Nguyen JT, Grijalva V, et al: Potential role for mitogen-activated protein kinase phosphatase-1 in the development of atherosclerotic lesions in mouse models. Arterioscler Thromb Vasc Biol. 24:1676–1681. 2004. View Article : Google Scholar : PubMed/NCBI | |
|
Shen J, Chandrasekharan UM, Ashraf MZ, et al: Lack of mitogen-activated protein kinase phosphatase-1 protects ApoE-null mice against atherosclerosis. Circ Res. 106:902–910. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Imaizumi S, Grijalva V, Priceman S, et al: Mitogen-activated protein kinase phosphatase-1 deficiency decreases atherosclerosis in apolipoprotein E null mice by reducing monocyte chemoattractant protein-1 levels. Mol Genet Metab. 101:66–75. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Lacolley P, Regnault V, Nicoletti A, Li Z and Michel JB: The vascular smooth muscle cell in arterial pathology: a cell that can take on multiple roles. Cardiovasc Res. 95:194–204. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Lai K, Wang H, Lee WS, Jain MK, Lee ME and Haber E: Mitogen-activated protein kinase phosphatase-1 in rat arterial smooth muscle cell proliferation. J Clin Invest. 98:1560–1567. 1996. View Article : Google Scholar : PubMed/NCBI | |
|
Koyama H, Olson NE, Dastvan FF and Reidy MA: Cell replication in the arterial wall: activation of signaling pathway following in vivo injury. Circ Res. 82:713–721. 1998. View Article : Google Scholar : PubMed/NCBI | |
|
Metzler B, Li C, Hu Y, Sturm G, Ghaffari-Tabrizi N and Xu Q: LDL stimulates mitogen-activated protein kinase phosphatase-1 expression, independent of LDL receptors, in vascular smooth muscle cells. Arterioscler Thromb Vasc Biol. 19:1862–1871. 1999. View Article : Google Scholar : PubMed/NCBI | |
|
Gouni-Berthold I, Seewald S, Hescheler J and Sachinidis A: Regulation of mitogen-activated protein kinase cascades by low density lipoprotein and lysophosphatidic acid. Cell Physiol Biochem. 14:167–176. 2004. View Article : Google Scholar : PubMed/NCBI | |
|
Gao Y, Deng J, Yu XF, Yang DL, Gong QH and Huang XN: Ginsenoside Rg1 inhibits vascular intimal hyperplasia in balloon-injured rat carotid artery by down-regulation of extracellular signal-regulated kinase 2. J Ethnopharmacol. 138:472–478. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Kim SY, Kwon YW, Jung IL, Sung JH and Park SG: Tauroursodeoxycholate (TUDCA) inhibits neointimal hyperplasia by suppression of ERK via PKCalpha-mediated MKP-1 induction. Cardiovasc Res. 92:307–316. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Yang YB, Yang YX, Su B, et al: Probucol mediates vascular remodeling after percutaneous transluminal angioplasty via down-regulation of the ERK1/2 signaling pathway. Eur J Pharmacol. 570:125–134. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Begum N, Song Y, Rienzie J and Ragolia L: Vascular smooth muscle cell growth and insulin regulation of mitogen-activated protein kinase in hypertension. Am J Physiol. 275:C42–C49. 1998.PubMed/NCBI | |
|
Begum N and Ragolia L: High glucose and insulin inhibit VSMC MKP-1 expression by blocking iNOS via p38 MAPK activation. Am J Physiol Cell Physiol. 278:C81–C91. 2000.PubMed/NCBI | |
|
Jacob A, Smolenski A, Lohmann SM and Begum N: MKP-1 expression and stabilization and cGK Ialpha prevent diabetes-associated abnormalities in VSMC migration. Am J Physiol Cell Physiol. 287:C1077–C1086. 2004. View Article : Google Scholar : PubMed/NCBI | |
|
Jacob A, Molkentin JD, Smolenski A, Lohmann SM and Begum N: Insulin inhibits PDGF-directed VSMC migration via NO/cGMP increase of MKP-1 and its inactivation of MAPKs. Am J Physiol Cell Physiol. 283:C704–C713. 2002. View Article : Google Scholar : PubMed/NCBI | |
|
Li B, Yang L, Shen J, Wang C and Jiang Z: The antiproliferative effect of sildenafil on pulmonary artery smooth muscle cells is mediated via upregulation of mitogen-activated protein kinase phosphatase-1 and degradation of extracellular signal-regulated kinase 1/2 phosphorylation. Anesth Analg. 105:1034–1041, table of contents. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Jin Y, Calvert TJ, Chen B, et al: Mice deficient in Mkp-1 develop more severe pulmonary hypertension and greater lung protein levels of arginase in response to chronic hypoxia. Am J Physiol Heart Circ Physiol. 298:H1518–H1528. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Yamboliev IA, Hedges JC, Mutnick JL, Adam LP and Gerthoffer WT: Evidence for modulation of smooth muscle force by the p38 MAP kinase/HSP27 pathway. Am J Physiol Heart Circ Physiol. 278:H1899–H1907. 2000.PubMed/NCBI | |
|
Han W, Tang X, Wu H, Liu Y and Zhu D: Role of ERK1/2 signaling pathways in 4-aminopyridine-induced rat pulmonary vasoconstriction. Eur J Pharmacol. 569:138–144. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Khan TA, Bianchi C, Ruel M, et al: Mitogen-activated protein kinase inhibition and cardioplegia-cardiopulmonary bypass reduce coronary myogenic tone. Circulation. 108(Suppl 1): II348–II353. 2003. View Article : Google Scholar : PubMed/NCBI | |
|
Suzuki H, Hasegawa Y, Chen W, Kanamaru K and Zhang JH: Recombinant osteopontin in cerebral vasospasm after subarachnoid hemorrhage. Ann Neurol. 68:650–660. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Tong XK and Hamel E: Transforming growth factor-beta 1 impairs endothelin-1-mediated contraction of brain vessels by inducing mitogen-activated protein (MAP) kinase phosphatase-1 and inhibiting p38 MAP kinase. Mol Pharmacol. 72:1476–1483. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Xu Q, Fawcett TW, Gorospe M, Guyton KZ, Liu Y and Holbrook NJ: Induction of mitogen-activated protein kinase phosphatase-1 during acute hypertension. Hypertension. 30:106–111. 1997. View Article : Google Scholar : PubMed/NCBI | |
|
Huang PL, Huang Z, Mashimo H, et al: Hypertension in mice lacking the gene for endothelial nitric oxide synthase. Nature. 377:239–242. 1995. View Article : Google Scholar : PubMed/NCBI | |
|
Zhao Q, Wang X, Nelin LD, et al: MAP kinase phosphatase 1 controls innate immune responses and suppresses endotoxic shock. J Exp Med. 203:131–140. 2006. View Article : Google Scholar | |
|
Calvert TJ, Chicoine LG, Liu Y and Nelin LD: Deficiency of mitogen-activated protein kinase phosphatase-1 results in iNOS-mediated hypotension in response to low-dose endotoxin. Am J Physiol Heart Circ Physiol. 294:H1621–H1629. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Kan W, Zhao KS, Jiang Y, et al: Lung, spleen, and kidney are the major places for inducible nitric oxide synthase expression in endotoxic shock: role of p38 mitogen-activated protein kinase in signal transduction of inducible nitric oxide synthase expression. Shock. 21:281–287. 2004. View Article : Google Scholar : PubMed/NCBI | |
|
Klinge CM, Blankenship KA, Risinger KE, et al: Resveratrol and estradiol rapidly activate MAPK signaling through estrogen receptors alpha and beta in endothelial cells. J Biol Chem. 280:7460–7468. 2005. View Article : Google Scholar | |
|
Uchiba M, Okajima K, Oike Y, et al: Activated protein C induces endothelial cell proliferation by mitogen-activated protein kinase activation in vitro and angiogenesis in vivo. Circ Res. 95:34–41. 2004. View Article : Google Scholar : PubMed/NCBI | |
|
Xing F, Jiang Y, Liu J, et al: Downregulation of human endothelial nitric oxide synthase promoter activity by p38 mitogen-activated protein kinase activation. Biochem Cell Biol. 84:780–788. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Niwano K, Arai M, Koitabashi N, et al: Competitive binding of CREB and ATF2 to cAMP/ATF responsive element regulates eNOS gene expression in endothelial cells. Arterioscler Thromb Vasc Biol. 26:1036–1042. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Gupta A and Sharma AC: Despite minimal hemodynamic alterations endotoxemia modulates NOS and p38-MAPK phosphorylation via metalloendopeptidases. Mol Cell Biochem. 265:47–56. 2004. View Article : Google Scholar : PubMed/NCBI | |
|
Saxena M and Mustelin T: Extracellular signals and scores of phosphatases: all roads lead to MAP kinase. Semin Immunol. 12:387–396. 2000. View Article : Google Scholar : PubMed/NCBI | |
|
Rose BA, Force T and Wang Y: Mitogen-activated protein kinase signaling in the heart: angels versus demons in a heart-breaking tale. Physiol Rev. 90:1507–1546. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Fuller SJ, Davies EL, Gillespie-Brown J, Sun H and Tonks NK: Mitogen-activated protein kinase phosphatase 1 inhibits the stimulation of gene expression by hypertrophic agonists in cardiac myocytes. Biochem J. 323:313–319. 1997.PubMed/NCBI | |
|
Hayashi D, Kudoh S, Shiojima I, et al: Atrial natriuretic peptide inhibits cardiomyocyte hypertrophy through mitogen-activated protein kinase phosphatase-1. Biochem Biophys Res Commun. 322:310–319. 2004. View Article : Google Scholar : PubMed/NCBI | |
|
Goldsmith EC, Bradshaw AD, Zile MR and Spinale FG: Myocardial fibroblast-matrix interactions and potential therapeutic targets. J Mol Cell Cardiol. 70:92–99. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Stawowy P, Goetze S, Margeta C, Fleck E and Graf K: LPS regulate ERK1/2-dependent signaling in cardiac fibroblasts via PKC-mediated MKP-1 induction. Biochem Biophys Res Commun. 303:74–80. 2003. View Article : Google Scholar : PubMed/NCBI | |
|
Valente AJ, Yoshida T, Gardner JD, Somanna N, Delafontaine P and Chandrasekar B: Interleukin-17A stimulates cardiac fibroblast proliferation and migration via negative regulation of the dual-specificity phosphatase MKP-1/DUSP-1. Cell Signal. 24:560–568. 2012. View Article : Google Scholar : | |
|
Short MD, Fox SM, Lam CF, Stenmark KR and Das M: Protein kinase Czeta attenuates hypoxia-induced proliferation of fibroblasts by regulating MAP kinase phosphatase-1 expression. Mol Biol Cell. 17:1995–2008. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Bueno OF, De Windt LJ, Lim HW, et al: The dual-specificity phosphatase MKP-1 limits the cardiac hypertrophic response in vitro and in vivo. Circ Res. 88:88–96. 2001. View Article : Google Scholar : PubMed/NCBI | |
|
Auger-Messier M, Accornero F, Goonasekera SA, et al: Unrestrained p38 MAPK activation in Dusp1/4 double-null mice induces cardiomyopathy. Circ Res. 112:48–56. 2013. View Article : Google Scholar | |
|
Ueyama T, Kawashima S, Sakoda T, et al: Requirement of activation of the extracellular signal-regulated kinase cascade in myocardial cell hypertrophy. J Mol Cell Cardiol. 32:947–960. 2000. View Article : Google Scholar : PubMed/NCBI | |
|
Wang Y, Huang S, Sah VP, et al: Cardiac muscle cell hypertrophy and apoptosis induced by distinct members of the p38 mitogen-activated protein kinase family. J Biol Chem. 273:2161–2168. 1998. View Article : Google Scholar : PubMed/NCBI | |
|
Wang Y, Su B, Sah VP, Brown JH, Han J and Chien KR: Cardiac hypertrophy induced by mitogen-activated protein kinase kinase 7, a specific activator for c-Jun NH2-terminal kinase in ventricular muscle cells. J Biol Chem. 273:5423–5426. 1998. View Article : Google Scholar : PubMed/NCBI | |
|
Deng J, Lv XT, Wu Q and Huang XN: Ginsenoside Rg1 inhibits rat left ventricular hypertrophy induced by abdominal aorta coarctation: involvement of calcineurin and mitogen-activated protein kinase signalings. Eur J Pharmacol. 608:42–47. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Dash R, Schmidt AG, Pathak A, et al: Differential regulation of p38 mitogen-activated protein kinase mediates gender-dependent catecholamine-induced hypertrophy. Cardiovasc Res. 57:704–714. 2003. View Article : Google Scholar : PubMed/NCBI | |
|
McCollum LT, Gallagher PE and Ann Tallant E: Angiotensin-(1–7) attenuates angiotensin II-induced cardiac remodeling associated with upregulation of dual-specificity phosphatase 1. Am J Physiol Heart Circ Physiol. 302:H801–H810. 2012. View Article : Google Scholar | |
|
Choudhary R, Palm-Leis A, Scott RC III, et al: All-trans retinoic acid prevents development of cardiac remodeling in aortic banded rats by inhibiting the renin-angiotensin system. Am J Physiol Heart Circ Physiol. 294:H633–H644. 2008. View Article : Google Scholar | |
|
Ohki R, Yamamoto K, Ueno S, et al: Transcriptional profile of genes induced in human atrial myocardium with pressure overload. Int J Cardiol. 96:381–387. 2004. View Article : Google Scholar : PubMed/NCBI | |
|
Communal C, Colucci WS, Remondino A, et al: Reciprocal modulation of mitogen-activated protein kinases and mitogen-activated protein kinase phosphatase 1 and 2 in failing human myocardium. J Card Fail. 8:86–92. 2002. View Article : Google Scholar : PubMed/NCBI | |
|
Kaiser RA, Bueno OF, Lips DJ, et al: Targeted inhibition of p38 mitogen-activated protein kinase antagonizes cardiac injury and cell death following ischemia-reperfusion in vivo. J Biol Chem. 279:15524–15530. 2004. View Article : Google Scholar : PubMed/NCBI | |
|
Fan WJ, Genade S, Genis A, Huisamen B and Lochner A: Dexamethasone-induced cardioprotection: a role for the phosphatase MKP-1? Life Sci. 84:838–846. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Engelbrecht AM, Engelbrecht P, Genade S, et al: Long-chain polyunsaturated fatty acids protect the heart against ischemia/reperfusion-induced injury via a MAPK dependent pathway. J Mol Cell Cardiol. 39:940–954. 2005. View Article : Google Scholar : PubMed/NCBI | |
|
Xie P, Guo S, Fan Y, Zhang H, Gu D and Li H: Atrogin-1/MAFbx enhances simulated ischemia/reperfusion-induced apoptosis in cardiomyocytes through degradation of MAPK phosphatase-1 and sustained JNK activation. J Biol Chem. 284:5488–5496. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Przyklenk K, Maynard M, Darling CE and Whittaker P: Aging mouse hearts are refractory to infarct size reduction with post-conditioning. J Am Coll Cardiol. 51:1393–1398. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Lips DJ, Bueno OF, Wilkins BJ, et al: MEK1-ERK2 signaling pathway protects myocardium from ischemic injury in vivo. Circulation. 109:1938–1941. 2004. View Article : Google Scholar : PubMed/NCBI | |
|
Engelbrecht AM, Niesler C, Page C and Lochner A: p38 and JNK have distinct regulatory functions on the development of apoptosis during simulated ischaemia and reperfusion in neonatal cardiomyocytes. Basic Res Cardiol. 99:338–350. 2004. View Article : Google Scholar : PubMed/NCBI | |
|
Mocanu MM, Baxter GF, Yue Y, Critz SD and Yellon DM: The p38 MAPK inhibitor, SB203580, abrogates ischaemic preconditioning in rat heart but timing of administration is critical. Basic Res Cardiol. 95:472–478. 2000. View Article : Google Scholar |
