Pleiotropic Regulation of Ubiquitin-Proteasome System in Cellular Homeostasis

The regulation of selective proteolysis in cellular homeostasis is primarily controlled by post-translational modification using the ubiquitin-proteasome system. Ubiquitination and deubiquitination play pivotal roles in modulating protein stability, cellular functions, protein turnover, signaling pathways, and the DNA damage response. Dysregulation of these processes is increasingly recognized as a causal factor in various human diseases, including cancer, metabolic disorders, and neurodegenerative conditions. Consequently, gaining a deeper understanding of the molecular mechanisms governing cellular homeostasis holds promise for the development of targeted therapeutic approaches.

Submission deadline: 11/10/2024