miR-221/222 promote malignant progression of glioma through activation of the Akt pathway

  • Authors: Junxia Zhang, Lei Han, Youlin Ge, Xuan Zhou, Anling Zhang, Chunzhi Zhang, Yue Zhong, Yongping You, Peiyu Pu, Chunsheng Kang
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  • Published online on: Thursday, April 1, 2010
  • Pages: 913-920
  • DOI: 10.3892/ijo_00000570

Abstract

MicroRNAs (miRNAs) are short regulatory RNAs that negatively modulate protein expression at a post-transcriptional level. Emerging evidence suggests that miRNAs play important roles in the pathogenesis of several types of cancers. However, the further mechanisms of miRNA remain unknown. In this study, we aimed to explore the coordinated function of miR-221/222 in glioma by bioinformatics and experiment methods. Bioinformatics analysis revealed that miR-221/222 had the potential to regulate about 70 common target genes and may exert a cooperative effect on regulation and function via Akt signaling pathway. Overexpression of miR-221/222 increased glioma cell proliferation and invasion in vitro and induced glioma growth in a subcutaneous mouse model. Furthermore, miR-221/222 overexpression resulted in an obvious activation of p-Akt and significant changes of Akt-related gene expression in glioma cells. Our results suggest that miR-221/222 co-enhance the glioma malignant phenotype via activation of the Akt pathway mediated by regulation of common gene expression.
Journal Cover

April 2010
Volume 36 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

2012 Impact Factor: 2.657
Ranked #31/196 Oncology
(total number of cites)

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APA
Zhang, J., Han, L., Ge, Y., Zhou, X., Zhang, A., Zhang, C., Zhong, Y., You, Y., Pu, P., & Kang, C. (2010). miR-221/222 promote malignant progression of glioma through activation of the Akt pathway. International Journal of Oncology, 36(4), 913-920.
MLA
Zhang, Han, Ge, Zhou, Zhang, Zhang, Zhong, You, Pu, and Chunsheng Kang. "miR-221/222 promote malignant progression of glioma through activation of the Akt pathway." International Journal of Oncology International Journal of Oncology 36.4 (2010): 913-920.
Chicago
Zhang, Han, Ge, Zhou, Zhang, Zhang, Zhong, You, Pu, and Chunsheng Kang. "miR-221/222 promote malignant progression of glioma through activation of the Akt pathway." International Journal of Oncology International Journal of Oncology 36 no. 4 (2010): 913-920.