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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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February 2012 Volume 5 Issue 2

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Review

Bimodal actions of selenium essential for antioxidant and toxic pro-oxidant activities: The selenium paradox (Review)

  • Authors:
    • Kyung Hee Lee
    • Daewon Jeong

  • View Affiliations / Copyright

    Affiliations: Department of Microbiology and Aging-Associated Vascular Disease Research Center, Yeungnam University College of Medicine, Daegu 705-717, Republic of Korea
  • Pages: 299-304
    |
    Published online on: October 31, 2011
       https://doi.org/10.3892/mmr.2011.651
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Abstract

Selenium is an essential biological trace element. Adult daily intake of selenium should be approximately 100 µg per day. This compound has a two-sided effect depending on its concentration. A selenium-deficient diet is associated with various endemic diseases, including cardiomuscular malfunctions, osteoarthritis, cancer and viral infections that lead to premature death. These defects are prevented when dietary intake of selenium is adequate. The preventive biological effect of selenium is considered to be due to the antioxidant function of selenoproteins with a selenocysteine in the active site of the catalytic domain. Antioxidant selenoproteins maintain the intracellular redox status and, as a result, normal physiological processes in the cell. Conversely, an overdose of selenium generates oxygen radicals and leads to apoptotic cell death by inducing oxidation and cross-linking of protein thiol groups essential for cell survival. A lower redox state caused by selenium may be implicated in toxic diseases, such as alkali disease and blind staggers. Collectively, selenium seems to have both harmful and beneficial attributes. The aim of this review is to summarize the various biological functions of selenium and to illustrate its opposite roles as a pro-oxidant and an antioxidant.

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Copy and paste a formatted citation
Spandidos Publications style
Lee K and Jeong D: Bimodal actions of selenium essential for antioxidant and toxic pro-oxidant activities: The selenium paradox (Review). Mol Med Rep 5: 299-304, 2012.
APA
Lee, K., & Jeong, D. (2012). Bimodal actions of selenium essential for antioxidant and toxic pro-oxidant activities: The selenium paradox (Review). Molecular Medicine Reports, 5, 299-304. https://doi.org/10.3892/mmr.2011.651
MLA
Lee, K., Jeong, D."Bimodal actions of selenium essential for antioxidant and toxic pro-oxidant activities: The selenium paradox (Review)". Molecular Medicine Reports 5.2 (2012): 299-304.
Chicago
Lee, K., Jeong, D."Bimodal actions of selenium essential for antioxidant and toxic pro-oxidant activities: The selenium paradox (Review)". Molecular Medicine Reports 5, no. 2 (2012): 299-304. https://doi.org/10.3892/mmr.2011.651
Copy and paste a formatted citation
x
Spandidos Publications style
Lee K and Jeong D: Bimodal actions of selenium essential for antioxidant and toxic pro-oxidant activities: The selenium paradox (Review). Mol Med Rep 5: 299-304, 2012.
APA
Lee, K., & Jeong, D. (2012). Bimodal actions of selenium essential for antioxidant and toxic pro-oxidant activities: The selenium paradox (Review). Molecular Medicine Reports, 5, 299-304. https://doi.org/10.3892/mmr.2011.651
MLA
Lee, K., Jeong, D."Bimodal actions of selenium essential for antioxidant and toxic pro-oxidant activities: The selenium paradox (Review)". Molecular Medicine Reports 5.2 (2012): 299-304.
Chicago
Lee, K., Jeong, D."Bimodal actions of selenium essential for antioxidant and toxic pro-oxidant activities: The selenium paradox (Review)". Molecular Medicine Reports 5, no. 2 (2012): 299-304. https://doi.org/10.3892/mmr.2011.651
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