Null genotypes of glutathione S-transferase µ1 and glutathione S-transferase θ1 are associated with osteosarcoma risk: A meta-analysis

  • Authors:
    • Jicheng Han
    • Wei Deng
    • Laiying Wang
    • Wanli Qi
  • View Affiliations

  • Published online on: February 10, 2015     https://doi.org/10.3892/ol.2015.2955
  • Pages: 1912-1916
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Abstract

Glutathione S‑transferase (GST) genetic polymorphisms has been reported to be associated with osteosarcoma; however, the results of previous studies are conflicting. Thus, in the present study, a meta‑analysis was conducted to investigate the effects of GSTM1 and GSTT1 polymorphisms on osteosarcoma risk. A literature search was performed in the PubMed, Cochrane Library and China National Knowledge Infrastructure databases to identify case‑control studies published prior to March 2014. Data were extracted and pooled odds ratios (OR) with 95% confidence intervals (CI) were calculated. In addition, Begg's test was used to measure publication bias. Sensitivity analysis were performed to ensure the accuracy of the results. The meta‑analysis results demonstrated no significant association between the null genotype of GSTM1 and osteosarcoma risk (OR=0.83; 95% CI, 0.37‑1.85). By contrast, the results revealed a significant association for the comparison of null vs. non‑null genotypes of GSTT1 (OR=1.54; 95% CI, 1.09‑2.19). In conclusion, the GSTT1 null genotype may be associated with an increased risk of deve­loping osteosarcoma. Further studies with larger sample sizes and well‑designed methodologies are required to verify these conclusions.
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April-2015
Volume 9 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Han J, Deng W, Wang L and Qi W: Null genotypes of glutathione S-transferase µ1 and glutathione S-transferase θ1 are associated with osteosarcoma risk: A meta-analysis. Oncol Lett 9: 1912-1916, 2015.
APA
Han, J., Deng, W., Wang, L., & Qi, W. (2015). Null genotypes of glutathione S-transferase µ1 and glutathione S-transferase θ1 are associated with osteosarcoma risk: A meta-analysis. Oncology Letters, 9, 1912-1916. https://doi.org/10.3892/ol.2015.2955
MLA
Han, J., Deng, W., Wang, L., Qi, W."Null genotypes of glutathione S-transferase µ1 and glutathione S-transferase θ1 are associated with osteosarcoma risk: A meta-analysis". Oncology Letters 9.4 (2015): 1912-1916.
Chicago
Han, J., Deng, W., Wang, L., Qi, W."Null genotypes of glutathione S-transferase µ1 and glutathione S-transferase θ1 are associated with osteosarcoma risk: A meta-analysis". Oncology Letters 9, no. 4 (2015): 1912-1916. https://doi.org/10.3892/ol.2015.2955