MicroRNA-127-3p promotes glioblastoma cell migration and invasion by targeting the tumor-suppressor gene SEPT7

  • Authors:
    • Huawei Jiang
    • Dasong Hua
    • Jing Zhang
    • Qing Lan
    • Qiang Huang
    • Jae-Geun Yoon
    • Xu Han
    • Lisha Li
    • Gregory Foltz
    • Shu Zheng
    • Biaoyang Lin
  • Corresponding author:
  • View Affiliations

  • Published online on: Wednesday, March 5, 2014
  • Pages: 2261-2269
  • DOI: 10.3892/or.2014.3055

Abstract

MicroRNAs (miRNAs) are small non-coding RNAs of 20-25 nucleotides in length that are capable of modulating gene expression post-transcriptionally. The potential roles of miRNAs in the tumorigenesis of glioblastoma (GBM) have been under intensive studies in the past few years. In the present study, we found a positive correlation between the levels of miR-127-3p and the cell migration and invasion abilities in several human GBM cell lines. We showed that miR-127-3p promoted cell migration and invasion of GBM cells using in vitro cell lines and in vivo mouse models. We identified SEPT7, a known tumor-suppressor gene that has been reported to suppress GBM cell migration and invasion, as a direct target of miR-127-3p. SEPT7 was able to partially abrogate the effect of miR-127-3p on cell migration and invasion. In addition, microarray analysis revealed that miR-127-3p regulated a number of migration and invasion-related genes. Finally, we verified that miR-127-3p affected the remodeling of the actin cytoskeleton mediated by SEPT7 in GBM cells.
Journal Cover

May 2014
Volume 31 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

2013 Impact Factor: 2.191
Ranked #33/202 Oncology
(total number of cites)

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APA
Jiang, H., Hua, D., Zhang, J., Lan, Q., Huang, Q., Yoon, J. ... Lin, B. (2014). MicroRNA-127-3p promotes glioblastoma cell migration and invasion by targeting the tumor-suppressor gene SEPT7. Oncology Reports, 31, 2261-2269. http://dx.doi.org/10.3892/or.2014.3055
MLA
Jiang, H., Hua, D., Zhang, J., Lan, Q., Huang, Q., Yoon, J., Han, X., Li, L., Foltz, G., Zheng, S., Lin, B."MicroRNA-127-3p promotes glioblastoma cell migration and invasion by targeting the tumor-suppressor gene SEPT7". Oncology Reports 31.5 (2014): 2261-2269.
Chicago
Jiang, H., Hua, D., Zhang, J., Lan, Q., Huang, Q., Yoon, J., Han, X., Li, L., Foltz, G., Zheng, S., Lin, B."MicroRNA-127-3p promotes glioblastoma cell migration and invasion by targeting the tumor-suppressor gene SEPT7". Oncology Reports 31, no. 5 (2014): 2261-2269. http://dx.doi.org/10.3892/or.2014.3055