MicroRNA-127-3p promotes glioblastoma cell migration and invasion by targeting the tumor-suppressor gene SEPT7

  • Authors:
    • Huawei Jiang
    • Dasong Hua
    • Jing Zhang
    • Qing Lan
    • Qiang Huang
    • Jae-Geun Yoon
    • Xu Han
    • Lisha Li
    • Gregory Foltz
    • Shu Zheng
    • Biaoyang Lin
  • View Affiliations

  • Published online on: Wednesday, March 5, 2014
  • Pages: 2261-2269
  • DOI: 10.3892/or.2014.3055

Abstract

MicroRNAs (miRNAs) are small non-coding RNAs of 20-25 nucleotides in length that are capable of modulating gene expression post-transcriptionally. The potential roles of miRNAs in the tumorigenesis of glioblastoma (GBM) have been under intensive studies in the past few years. In the present study, we found a positive correlation between the levels of miR-127-3p and the cell migration and invasion abilities in several human GBM cell lines. We showed that miR-127-3p promoted cell migration and invasion of GBM cells using in vitro cell lines and in vivo mouse models. We identified SEPT7, a known tumor-suppressor gene that has been reported to suppress GBM cell migration and invasion, as a direct target of miR-127-3p. SEPT7 was able to partially abrogate the effect of miR-127-3p on cell migration and invasion. In addition, microarray analysis revealed that miR-127-3p regulated a number of migration and invasion-related genes. Finally, we verified that miR-127-3p affected the remodeling of the actin cytoskeleton mediated by SEPT7 in GBM cells.
Journal Cover

May 2014
Volume 31 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

2013 Impact Factor: 2.191
Ranked #33/202 Oncology
(total number of cites)

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APA
Jiang, H., Jiang, H., Hua, D., Hua, D., Zhang, J., Zhang, J., Lan, Q., Lan, Q., Huang, Q., Huang, Q., Yoon, J., Yoon, J., Han, X., Han, X., Li, L., Li, L., Foltz, G., Foltz, G., Zheng, S., Zheng, S., Lin, B., & Lin, B. (2014). MicroRNA-127-3p promotes glioblastoma cell migration and invasion by targeting the tumor-suppressor gene SEPT7. Oncology Reports, 31(5), 2261-2269.
MLA
Jiang, Jiang, Hua, Hua, Zhang, Zhang, Lan, Lan, Huang, Huang, Yoon, Yoon, Han, Han, Li, Li, Foltz, Foltz, Zheng, Zheng, Lin, and Biaoyang Lin. "MicroRNA-127-3p promotes glioblastoma cell migration and invasion by targeting the tumor-suppressor gene SEPT7." Oncology Reports Oncology Reports 31.5 (2014): 2261-2269.
Chicago
Jiang, Jiang, Hua, Hua, Zhang, Zhang, Lan, Lan, Huang, Huang, Yoon, Yoon, Han, Han, Li, Li, Foltz, Foltz, Zheng, Zheng, Lin, and Biaoyang Lin. "MicroRNA-127-3p promotes glioblastoma cell migration and invasion by targeting the tumor-suppressor gene SEPT7." Oncology Reports Oncology Reports 31 no. 5 (2014): 2261-2269.